Relations between serum magnesium and calcium levels and body composition and metabolic parameters in women with fibromyalgia

Abstract Objective: Correlate serum magnesium (Mg) and Calcium (Ca) levels with body composition and metabolic parameters in women with fibromyalgia (FM). Patients and methods: Cross-sectional study compared with a control group paired by age and body mass index (BMI) of adult women diagnosed with fibromyalgia. All participants went through assessment of their body composition through dual-energy X-ray absorptiometry (DXA) and had blood samples collected for dosing of Mg, Ca, C-reactive Protein (CRP), lipidogram and glycemia. Results: 53 women with FM (average age 48.1 ±8.2 years, average BMI 26.6 ±4.5 kg/m2) and 50 control women (average age 47.1 ±9.9 years, average BMI 25.6 ± 3.6 kg/m2) participated in the study. Serum levels turned out to have inverse correlation with CRP in the FM group (r = −0.29, p = 0.03) and with BMI and glycemia in the control group (r = 0.31; p = 0.02 and r = 0.48; p = 0.0004 respectively). Serum levels of calcium correlated with triglycerides (r = 0.29; p = 0.03) in the FM group and with glycemia in the control group (r = 0.64; p = 0.0001). Conclusions: In patients with FM, magnesemia turned out to have inverse correlation with CRP and calcemia had positive association with triglycerides.(AU)

Enfermedad hepática por depósito de grasa / Hepatic disease due to fat deposit

La enfermedad hepática por depósito de grasa adquiere cada vez una importancia mayor como entidad y, al mismo tiempo, como factor de riesgo aislado o asociado al síndrome metabólico. Con el objetivo de actualizar algunos aspectos relacionados con esta hepatopatía, tales como su actual nomenclatura y nuevo enfoque etiopatogénico, se efectuó la presente revisión bibliográfica desde una perspectiva clínica, la que incluye datos elementales sobre la fisiopatología y las características de presentación de la entidad, así como las principales armas utilizadas en su diagnóstico, control o terapéutica. Se demuestra, además, que la visión sobre el tema ha cambiado en los últimos años y constituye fuente de investigación en múltiples grupos prestigiosos por las particularidades de su evolución.

The hepatic disease due to fat deposit acquires greater importance as entity and, at the same time, as isolated or associated risk factor to the metabolic syndrome. With the objective of updating some aspects related to this hepatopathy, such as its current nomenclature and new etiopathogenic approach; the present literature review was carried out from a clinical perspective, which includes elementary data on the pathophysiology and the presentation characteristics of the entity, as well as the main tools used in its diagnosis, control or therapy. It is also demonstrated, that the vision on the topic has changed in the last years and it constitutes an investigation source in multiple noted groups due to the particularities of its clinical course.

Marcadores de respuesta inflamatoria y riesgo coronario en pacientes con artritis reumatoide / Markers of inflammatory response and coronary risk in patients with rheumatoid arthritis

Objetivo: evaluar la asociación entre los niveles séricos de Proteína C Reactiva e índices Apoproteína B/Apoproteína A1, Apoproteína B/LDL colesterol, LDL/HDL colesterol, índice aterogénico, lipoproteína (a) y componentes C3 y C4 del complemento sérico; así como la capacidad predictiva de la proteína C Reactiva, C3 y C4 complemento sobre los parámetros del lipidograma mencionados, se realizó un estudio transversal en pacientes portadores de Artritis Reumatoide y controles sanos de la provincia Matanzas. Métodos: las determinaciones de los parámetros individuales fueron realizadas por método inmunoturbidimétrico y enzimocolorimétrico. El Software estadístico SPSS, versión 18,0 fue empleado para el procesamiento de los resultados. Resultados: la correlación de Spearman detectó asociación de la proteína C Reactiva con los índices ApoB/LDL colesterol y LDL/HDL colesterol exclusivamente en los pacientes, Rho de Spearman= 0,439 (p=0,002); -0,300 (p=0,043), respectivamente; mientras manifestó asociación de esta con el C4 complemento en ambos grupos, Rho de Spearman= 0,355 (p=0,015); 0,376 (p=0,000), pacientes y controles, respectivamente. La proteína C reactiva predijo el índice ApoB/LDL colesterol mediante el análisis de regresión lineal en los pacientes: R²=0,192 F=10,488 (p=0,002), en tanto las proteínas del complemento C3 y C4 estimaron significativamente el nivel de lipoproteína(a); R²=0,170 F=4,396 (p=0,018). Los resultados apoyan la hipótesis del vínculo entre respuesta inflamatoria y predominio de Lipoproteínas de baja densidad más proaterogénicas; así como la posible estimación de marcadores del riesgo coronario relacionados con el metabolismo lipoproteico a partir de los niveles séricos de Proteína C Reactiva, C3 y C4 complemento en pacientes con Artritis Reumatoide...

Objective: evaluate the association between serum levels of C-reactive protein and the indices apoprotein B/apoprotein A1, apoprotein B/LDL cholesterol, LDL/HDL cholesterol, atherogenic index, lipoprotein (a) and serum complement components C3 and C4, as well as the prediction capacity of C-reactive protein, C3 and C4 complement with respect to the above mentioned lipidogram parameters. A cross-sectional study was conducted of patients with rheumatoid arthritis and healthy controls from the province of Matanzas. Methods: individual parameters were determined by immunoturbidimetry and enzymatic colorimetry. Results were processed with the statistical software SPSS version 18.0. Results: spearman rank correlation spotted an association of C-reactive protein with indices ApoB/LDL cholesterol and LDL/HDL cholesterol exclusively in patients, Spearman's Rho = 0.439 (p=0.002); -0.300 (p=0.043); -0.300 (p=0.043), respectively; and an association of C-reactive protein with C4 complement in both groups, Spearman's Rho = 0.355 (p=0.015); 0.376 (p=0.000), patients and controls, respectively. C-reactive protein predicted the ApoB/LDL cholesterol index by linear regression analysis in patients: R²=0.192 F=10.488 (p=0.002), whereas C3 and C4 complement proteins significantly estimated the level of lipoprotein (a): R²=0.170 F=4.396 (p=0.018). Results support the hypothesis about the link between inflammatory response and the predominance of more proatherogenic low density lipoproteins, as well as the potential estimation of coronary risk markers related to lipoprotein metabolism based on serum levels of C-reactive protein, C3 and C4 complement in patients with rheumatoid arthritis...

Parâmetros sanguíneos de vacas leiteiras suplementadas com diferentes fontes de gordura / Blood parameters of dairy cows supplemented with different fat sources

O objetivo deste trabalho foi avaliar a utilização de diferentes fontes de gordura nas rações de vacas em lactação e seus efeitos sobre o consumo de matéria seca e as concentrações dos parâmetros sangüíneos. Foram utilizadas 12 vacas da raça Holandês, agrupadas em três quadrados latinos balanceados 4x4 e alimentadas com as seguintes rações: 1) controle; 2) óleo de soja refinado; 3) grão de soja in natura; e 4) sais de cálcio de ácidos graxos (Megalac-E). As concentrações de colesterol total, colesterol, lipoproteína de baixa densidade (LDL) e colesterol de alta densidade (HDL) foram maiores (P<0,05) para as vacas alimentadas com as rações contendo fontes de gordura em relação à ração controle. As concentrações de uréia e nitrogênio ureico no soro foram semelhantes entre as rações utilizadas, com exceção da ração contendo sais de cálcio de ácidos graxos, que apresentou concentrações menores (P<0,05). O consumo de matéria seca foi menor (P<0,05) nas vacas que receberam sais de cálcio nas rações. Os animais que receberam a ração contendo grão de soja como fonte de gordura apresentaram menor (P<0,05) produção de leite quando comparada às demais rações utilizadas. A utilização de fontes de gordura em rações de vacas em lactação alterou os parâmetros sanguíneos, dependendo da fonte de gordura utilizada.

This study was carried out to evaluate the use of different fat sources in dairy cows rations and its effects on dry matter intake, milk yield and composition, and blood parameter. Twelve Holstein cows were allocated in three balanced latin square 4x4, and fed with the following rations: 1) Control, with 2.5 percent; 2) Refined soybean oil; 3) Whole soybean; and 4), Calcium salts of fatty acids (Megalac-E). The concentrations of total cholesterol and lipoprotein low density (LDL) were higher (P<0.05) for cows that received rations with fat sources, which also causes increased (P<0.05) e concentration of high density lipoprotein (HDL). The concentrations of urea and blood urea nitrogen were similar among the rations, except for the diet containing calcium salts of fatty acids, which showed lower (P<0.05). The dry matter intake was lower (P<0.05) in cows that received calcium salts in the rations. The animals that received a diet containing whole soybeans as a source of fat had lower (P<0.05) yield milk when compared to other rations used. The use of fat sources in dairy cows rations influenced the blood parameters, especially for parameters related to lipidogram.