Mielitis longitudinal asociada a lupus eritematososistémico / Longitudinal myelitis associated with systemic lupus erythematosus

Se presenta el caso de una mujer de 33 anos ˜ de edad con el diagnóstico de mielitis longitudinalsecundaria a lupus eritematoso sistémico. Presentó paraplejía e hipoestesia parasensibilidad térmica y dolorosa a nivel del dermatoma T6, recibió manejo con pulsos demetilprednisolona y ciclofosfamida con respuesta parcial al tratamiento. La mielitis es unaenfermedad inflamatoria que produce una lesión en la médula espinal, la mielitis longitudinalhace referencia a la participación continua de la médula espinal, con implicación de 3o más segmentos medulares contiguos. El tratamiento consiste en dosis altas de glucocorticoidescombinados o no con inmunosupresores o plasmaféresis...

Longitudinal Myelitis in the Cervical Cord Presenting Weakness of the Lower Extremities, as an Initial Manifestation of SLE / 대한류마티스학회지

Transverse myelitis is a rare and serious complication of systemic lupus erythematosus (SLE). Magnetic resonance imaging (MRI) shows cord swelling and increased signal intensity in T2-weighted images in a patient with transverse myelitis. We described a 45-year-old man presenting with weakness on the lower extremities without involvement of the upper extremities, as an initial manifestation of SLE. The lesion was involved continuous levels of the cervical spinal cord, a distinctive feature recently named 'longitudinal myelitis'. His symptoms and signs responded well to the cyclophosphamide and methylprednisolone pulse therapies. So far, 10 cases of longitudinal myelitis have been reported in the world. But only 2 cases presented lower extremities weakness rather than upper extremities, in spite of cervical spine involvement. We report a patient with longitudinal myelitis in the cervical cord presenting weakness of the lower extremities as an initial manifestation of SLE with literature review.

Extensive Longitudinal Myelitis Associated with Systemic Lupus Erythematosus: A case report

Myelopathy is a rare but serious central nervous system complication associated with systemic lupus erythematosus (SLE). Acute transverse myelitis is the most usual involvement of SLE-related myelopathy. We reported a 17-year-old girl who developed a very extensive SLE related transverse myelitis with longitudinal involvement of the spinal cordfrom C4 to the conus medullaris. There were motor and sensory loss of both lower extremities, and bladder dysfunction over the course of 5 days. She presented T9 paraplegia ASIA A. Her neurological dysfunction was not responded to treatment with methyprednisolone and cyclophosphomide.