Curative effect observation of capecitabine combined with intensity modulated radiotherapy for posto-perative mediastinum lymphonode metastasis in esophageal carcinoma / 国际肿瘤学杂志

Objective To evaluate the efficacy and toxicity of capecitabine combined with intensity modulated radiotherapy( IMRT)for postoperative mediastinal lymph node metastasis in esophageal cancer. Methods A total of 62 esophageal cancer patients with postoperative mediastinal lymph node metastases were randomly divided into the irradiation group(A group,31 cases)and the capecitabine combined with IMRT group( B group,31 cases). Both of two groups received IMRT radiotherapy with a total dose of 60-66 Gy, 30-33 times in 6-6. 5 weeks. The patients in B group were treated with capecitabine(1 250mg/ m2 ,2 f/ d, d1-d14,21 d × 2 cycle). Results Group A:there were 7 cases of complete response(CR),12 of partial response(PR),10 of stable disease(SD),and 2 of progressive disease(PD);the effective rate was 61. 3%(19 / 31). Group B:there were 10 cases of CR,16 of PR,4 of SD,and 1of PD;the effective rate was 83. 9%(26 / 31). There was a statistical significance between the effective rates of A group and B group(χ2 = 3. 971, P < 0. 05). Our experiment showed that the rates of grade Ⅱand Ⅲ myelosuppression in group A and group B were 29. 0% and 38. 7%(χ2 = 0. 648,P = 0. 421). The rates of Ⅰ and Ⅱ level radioactive pneumonia in group A and were 19. 4% and 25. 8%(χ2 = 0. 369,P = 0. 544). The different incidence of the two adverse reactions between group A and B had no statistical significance. Conclusion Compared with IMRT alone,IM-RT combined with capecitabine may have better curative efficacy without increasing toxicity to esophageal cancer patients with postoperative mediastinum lymphonode metastasis.

Diferença entre hospitais privado e universitário na taxa de linfonodos de peça cirúrgica de câncer colorretal: o papel do patologista / Difference between university and private hospitals on lymph nodes harvest of surgical colorectal cancer specimens: the role of the pathologist

Tem sido demonstrado que o número de linfonodos obtidos em peças cirúrgicas de câncer colorretal é fundamental para o adequado estadiamento da doença e, consequentemente, para a obtenção de melhores resultados oncológicos. A percepção de diferenças no número de linfonodos dissecados em peças cirúrgicas de câncer colorretal pelos mesmos cirurgiões em hospitais diferentes motivou este estudo. O objetivo do presente estudo foi avaliar se há diferença no número de linfonodos e em determinados parâmetros histopatológicos em peça cirúrgica de pacientes com câncer colorretal operados por dois cirurgiões que atuam tanto em hospital universitário, como em hospital privado. MÉTODO: Foram avaliados retrospectivamente 122 pacientes, obtendo-se dados relativos a tipo de instituição (universitária versus privada), aspectos demográficos, estadiamento, localização do tumor, tipo de operação, via de acesso (aberta versus laparoscópica ), indicação de radioterapia, número de linfonodos dissecados, número de linfonodos positivos e negativos, assim como o tipo histológico, presença de invasões vascular, linfática e perineural e resposta linfocítica). RESULTADOS: Sessenta e cinco pacientes foram operados em instituição universitária e 57, em instituição privada. Não houve diferença entre os grupos quanto à idade, gênero, estadiamento, localização do tumor, indicação de radioterapia e tipo de operação. A via laparoscópica foi mais comum na instituição universitária. A mediana de linfonodos dissecados foi de 25 (P25-75: 15-34) na instituição universitária versus 15 (P25-75;12-17) (p<.0001). A média de linfonodos positivos foi de três na instituição universitária e de um na privada. O achado de 12 ou mais linfonodos foi mais comum em instituição universitária (55/64 versus 40/58; p=.024). A presença da informação de invasões linfática, vascular e perineural foi mais comum na instituição universitária. CONCLUSÃO: Mantendo a mesma técnica cirúrgica e com população...

It has been demonstrated that lymph nodes harvest from surgical specimens of colorectal cancer is one of the most important features for appropriate staging of the disease and to plain the best treatment. The perception of differences in the number of harvest lymph nodes in surgical specimens of colorectal cancer by the same surgeons in different hospitals motivated this investigation. The aims of this study was to assess whether there is difference in the number of lymph nodes and some histopathological features in surgical specimens of colorectal cancer obtained by two surgeons who work both in a university hospital and in a private one. METHODS: We retrospectively evaluated 122 patients, obtaining data on the type of institution (university or private), demographic features, staging, tumor site, histological type, open or laparoscopic access, indication of radiotherapy, number of harvest lymph nodes, presence of vascular, lymphatic and neural invasions. RESULTS: Sixty-five patients were operated in a university institution and 57 in two private institutions. There was no difference between groups in terms of age, stage, tumor site, details of radiotherapy and type of operation. The laparoscopic route was more common in the university institution. The median of lymph nodes harvested was 25 (P25-75: 15-34) in the university institution and 15 in the private ones (P25-75, 12-17) (p <.0001). The finding of 12 or more lymph nodes was more common in academic institution (55/65 versus 40/57, p =. 024). The presence of information of lymphatic, vascular and perineural invasion was more common in the university institution. CONCLUSION: Keeping the same surgical technique and with comparable population of patients, there was considerable difference in the number of lymph nodes harvested between university and private institutions, as like as the report of other relevant data for the histopathological staging, which impacts indication for adjuvant...

The regularity of cervical lymph node metastasis of papillary thyroid cancer and selection of surgical procedure / 中国普通外科杂志

1 cm or tumor penetrating through the thyroid capsule(P1 cm or tumor penetrate through the thyroid capsule.

The risk factors of cervical lymph node recurrence after radiotherapy for neck negative nasophargneal carcinoma / 中华放射肿瘤学杂志

50 Gy in the upper neck as compared to those treated with seperate facial and neck fields to 0.05)Conclusions We suggest that patients with neck negative NPC should be treated with conjoint facio cervical lateral fields and prophylactic whole neck irradiation with more than 50 Gy to the upper neck.

Expression and significance of KAI1/CD82 and E-Cadherin in Human squamous cervical carcinoma / 西安交通大学学报(医学版)

Objective To investigate the expression and significance of KAI1/CD82 and E-Cadherin in human squamous cervical carcinoma.Methods The expressions of KAI1/CD82 and E-Cadherin were examined respectively by immunohistochemical S-P method in 10 cases of normal cervical tissue,15 cases of atypical hyperplasia of cervical epithelia and 64 cases of squamous cervical carcinoma.We analyzed statistically the correlation between the immunohistochemical results and the clinicopathological features.Results From normal cervical tissue,Cervical intraepithelial neoplasis(CIN) to cervical cancer,the positive expression rates of KAI1/CD82 and E-Cadherin were gradually decreased.Through statistic test,the positive expression rates of both invasive squamous carcinoma of the cervix were significantly lower in normal cervical tissue and CIN(P0.05).Of all the samples,direct correlation was showed in the expressions of KAI1/CD82 and E-Cadherin.Furthermore,the low-expression of both revealed significant correlation with lymphonode metastasis in human squamous cervical carcinoma.Conclusion KAI1/CD82 and(E-Cadherin) interactions may depress lymphonode metastasis in cervical carcinoma.Logistic analysis reveals that(E-Cadherin) gene,specific and interactions of several genes may be more significant during tumor metastasis.