The level of exhaled nitric oxide and its clinical significance in children with Mycoplasma pneumoniae pneumonia / 中国基层医药

Objective To investigate the changes of levels of exhaled nitric oxide and the clinical signifi -cance in children with Mycoplasma pneumoniae pneumonia ( MPP).Methods From June 2014 to March 2017,95 children with MPP and 64 children with bronchial pneumonia in Jinshan Branch of The Sixth People ＇s Hospital of Shanghai were collected,32 healthy children were enrolled as controls.According to the imaging examination,patients with MPP were further grouped into lobar pneumonia group,bronchopneumonia group and interstitial pneumonia group.FeNO and lung function were measured in all children.Results The level of FeNO in the MPP group was (7.25 ±3.41) ppb,which was lower than that in the non -MPP group and control group [(11.24 ±3.52) ppb,(10.51 ±4.23)ppb](t＝5.82,5.77,all P＜0.01).The level of FeNO between the non -MPP group and control group had no statistically significant difference (P＞0.05).The FEV1,FEV1/FVC%,FEF25%-75% of the MPP group[(66.23 ±13.21),(84.62 ±6.73),(58.65.±19.43)]were lower than those of the control group and non -MPP group[(91.81 ±11.36),(93.80 ±8.91),(86.80 ±20.71);(85.43 ±10.32),(90.18 ±11.35),(74.73 ± 17.91)](t＝4.35,3.62,4.78;4.56,7.12,5.06,all P＜0.01).The FEV1,FEV1/FVC%,FEF25%-75% of the non-MPP group[(85.43 ±10.32),(90.18 ±11.35),(74.73 ±17.91)]were lower than those of the control group [(91.81 ±11.36),(93.80 ±8.91),(86.80 ±20.71)] ( t＝2.12,3.05,2.53,all P＜0.05).The level of FeNO among the lobar pneumonia group,bronchopneumonia group and interstitial pneumonia group had no statistically significant difference ( all P ＞0.05 ).In the MPP group,the FEV1,FEV1/FVC%,FEF25% -75% were not associated with FeNO level(r＝-0.15,P＞0.05;r＝-0.06,P＞0.05;r＝0.07,P＞0.05).Conclusion The level of FeNO in children with MPP is lower,and the level of FeNO is not significantly correlated with the parameters of lung function,and FeNO can be used as an inflammatory marker to evaluate the correlation between MP infection and airway inflammation.

Repercusión del tabaquismo pasivo en la función ventilatoria de los trabajadores de una fábrica de cigarros

Se realiza un estudio descriptivo con el objetivo general de caracterizar funcionalmente el estado ventilatorio de 174 trabajadores, mediante la descripción del comportamiento de las pruebas funcionales respiratorias en los sujetos fumadores y no fumadores, previa identificación del hábito de fumar y del tabaquismo ambiental como factores de riesgo relevantes en la fábrica de cigarros «Orlando Nodarse». Se muestra en los resultados que todas las variables derivadas de las PFR presentaron valores anormales en una proporción elevada de los sujetos de manera global, y es predominante la presencia de trastornos ventilatorios restrictivos. No se encuentran diferencias significativas en los sujetos fumadores y no fumadores, lo que demostró valores anormales en cada una de las variables de las pruebas funcionales respiratorias estudiadas. Se derivan recomendaciones orientadas a lograr cambios de actitudes y mejoramiento de las condiciones ambientales en que se desenvuelven los trabajadores del centro.

A descriptive study is made on the basis of respiratory function tests applied to smoker and non-smoker subjects with the objective of functionally identifying the respiratory condition of 174 workers. Smoking habit and environmental tobacco smoke are previously identified as relevant risk factors in «Orlando Nodarse» cigarette factory. The results show that all the variables of the respiratory function tests generally yield anomalous values in a great number of subjects whereas restrictive respiratory disorders are predominant. No significant differences are found between smokers and non-smokers which brought about the existance of anomalous values in each of the variables of the respiratory function tests. Recommendations for a change of attitude and an improvement in the environmental working conditions of the factory are made.

MEASUREMENT OF WAXIMAL EXPIRATORY FLOW-VOLUME CURVE IN HEALTHY SUBJECTS AND PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE / 西安交通大学学报(医学版)

The maximal expiratory flow-volume (MEFV) curve were measured in 195 healthy adults. The results indicated that the values of the peak expiratory flow rate, V_(75), V_(50) and V_(25), were all higher in males than in females, and the higher the age, the lower the end expiratory flow rate. The end expiratory flow rate in chronic obstructive pulmonary disease (COPD) was decreased as the disease deteriorated. In healthy subjects, the V_(50)/V_(35) was increased with age, while in COPD patients V_(50) was decreased. The more severe the condition, the lower the rate. The authors suggest that the measurement of MEFV be used as a simple valuable method to evaluate small air way functiovs.