Pediatric bacterial meningitis and meningococcal disease profile in a Brazilian General Hospital

Abstract Objective To evaluate the clinical and epidemiological profile of bacterial meningitis and meningococcal disease in pediatric patients admitted to a Brazilian Secondary Public Hospital. Methods A descriptive observational study was conducted. Microbiologically proven bacterial meningitis or meningococcal disease diagnosed from 2008 to 2018 were included. Results A total of 90 patients were diagnosed with proven bacterial meningitis. There were 64 confirmed cases of meningococcal disease. The prevalence was higher in boys (n=38), median age 30 months (1-185). The main clinical manifestations were: meningococcal meningitis (n=27), meningococcemia without meningitis (n=14), association of meningococcemia with meningitis (n=13), and fever without a known source in infants (n=7).Admissions to intensive care unit were necessary for 45 patients. Three deaths were notified. Serogroup C was the most prevalent (n=32) followed by serogroup B (n=12).Pneumococcal meningitis was identified in 21 cases; out of the total, 10 were younger than two years. The identified serotypes were: 18C, 6B, 15A, 28, 7F, 12F, 15C, 19A and 14. Pneumococcal conjugate 10-valent vaccine covered four of the nine identified serotypes.Haemophilus influenzae meningitis serotype IIa was identified in three patients, median age 4 months (4-7). All of them needed intensive care. No deaths were notified. Conclusion Morbidity and mortality rates from bacterial meningitis and meningococcal disease remain high, requiring hospitalization and leading to sequelae. Our study observed a reduced incidence of bacterial disease over the last decade, possibly reflecting the impact of vaccination.

Efficacy, safety, and cost-effectiveness of meningococcal vaccines / 中华预防医学杂志

Meningococcal meningitis is an acute, severe respiratory infectious disease caused by Neisseria meningitidis. Immunization with meningococcal vaccine is the most effective measure to control and prevent transmission of meningococcal meningitis. Meningococcal vaccines in the Chinese market include meningococcal polysaccharide vaccine, meningococcal polysaccharide conjugate vaccine, and a combined vaccine containing meningococcal polysaccharide conjugate vaccine. This article reviews research progress on the efficacy, safety, and cost-effectiveness of meningococcal vaccines, particularly in the Chinese market, to support appropriate use of the various meningococcal vaccines for preventing meningococcal meningitis.

Efficacy, safety, and cost-effectiveness of meningococcal vaccines / 中华预防医学杂志

Meningococcal meningitis is an acute, severe respiratory infectious disease caused by Neisseria meningitidis. Immunization with meningococcal vaccine is the most effective measure to control and prevent transmission of meningococcal meningitis. Meningococcal vaccines in the Chinese market include meningococcal polysaccharide vaccine, meningococcal polysaccharide conjugate vaccine, and a combined vaccine containing meningococcal polysaccharide conjugate vaccine. This article reviews research progress on the efficacy, safety, and cost-effectiveness of meningococcal vaccines, particularly in the Chinese market, to support appropriate use of the various meningococcal vaccines for preventing meningococcal meningitis.

Cobertura da vacina meningocócica C nos estados e regiões do Brasil em 2012 / Coverage of the meningococcal C vaccine in the states and regions of Brazil in 2012 / Cobertura de la vacuna contra el meningococo C en los estados y regiones de Brasil en 2012

Objetivos: Descrever a cobertura da vacina meningocócica C em crianças menores de um ano de idade, em 2012, nos estados e regiões do Brasil, e correlacionar com variáveis socioeconômicas e cobertura da Estratégia de Saúde da Família. Métodos: Estudo ecológico. A cobertura vacinal foi calculada utilizando o número de doses da vacina em 2012, disponível no Sistema de Informação do Programa Nacional de Imunizações, como numerador, e população residente menor de um ano, também em 2012, como denominador. Ainda, foi realizada uma correlação de Pearson (r) entre a cobertura vacinal e as variáveis socioeconômicas. Resultados: As regiões Norte e Nordeste não atingiram a recomendação de 95% para cobertura. A cobertura vacinal apresentou correlação positiva moderada com renda média per capita (r=0,6) e negativa e moderada com o coeficiente de Gini (r=-0,5). Conclusão: São necessárias ações educativas e políticas para aumentar a cobertura vacinal com objetivo de reduzir a incidência da doença meningocócica, além de estudos com delineamentos mais robustos.

Objectives: To determine the coverage of the meningococcal C vaccine in children younger than one year of age in the states and regions of Brazil in 2012, and to correlate these findings with socioeconomic variables and the coverage of the Family Health Strategy. Methods: This was an ecological study. The vaccination coverage was calculated by dividing the number of vaccine doses administered in 2012 (numerator), which was determined from the data available in the Information System of the National Immunization Program, by the resident population less than one year also in 2012 (denominator). The Pearson correlation coefficient (r) was calculated for the vaccination coverage and socioeconomic variables. Results: The North and Northeast regions did not reach the recommended vaccination coverage (95%). The vaccination coverage showed a positive and moderate correlation with family income (r=0.6) and a negative and moderate correlation with the Gini coefficient (r=-0.5). Conclusion: Educational programs and policies are required to increase vaccination coverage and reduce the incidence of meningococcal disease. In addition, studies with more robust designs are necessary

Objetivos: Describir la cobertura de la vacuna contra el meningococo C en niños menores de un año de edad, en 2012, en los estados y regiones de Brasil, y correlacionar con variables socioeconómicas y cobertura de la Estrategia Salud de la Familia. Métodos: Estudio Ecológico. La cobertura de vacunación se calculó utilizando el número de dosis de la vacuna en 2012, disponible en el Sistema de Información del Programa Nacional de Inmunización, como numerador, y la población residente menor a un año, también en 2012, como denominador. Se realizó la correlación de Pearson (r) entre cobertura de la vacuna y las variables socioeconómicas. Resultados: En las regiones Norte y Noreste no alcanzaron la cobertura recomendada del 95%. La cobertura de vacunación mostró correlación positiva moderada con el ingreso promedio per cápita (r=0,6), y negativa moderada con el coeficiente de Gini (r=-0,5). Conclusión: Son necesarias acciones educativas e políticas para aumentar la cobertura de vacunación, con el fin de reducir la incidencia de la enfermedad meningocócica, así como los estudios con diseños más robustos.

Fatal meningococcal meningitis in a HIV-infected patient caused by serogroup C Neisseria meningitidis belonging to the non-hypervirulent clonal complex ST-60 (cc60)

Meningococcal strains belonging to clonal complex cc60 are not associated with hypervirulent lineages and were never reported as causing disease in Latin American countries. This is the first report of a fatal meningitis case caused by a cc60 clonal complex meningococcus in Brazil. Despite the immune-compromised state of the patient, the fatal outcome here described shows the potential pathogenic behavior of strains belonging to this clonal complex and how compromised hosts can be susceptible to meningococcal infections even if the strain is not particularly invasive.

Two Novel Mutations in the C7 gene in a Korean Patient with Complement C7 Deficiency

Complement C7 deficiency is an autosomal recessive disorder well known to be associated with increased susceptibility to meningococcal infection and has mostly been reported in Caucasians. In the Korean population, no case of C7 deficiency has been reported to date. Recently we experienced an 11-yr-old girl with meningococcal meningitis who was diagnosed as having C7 deficiency based upon the undetectable serum C7 protein on radial immunodiffusion and the undetectable serum total and C7 hemolytic activities. To identify the genetic basis of the C7 deficiency of the patient, we performed a mutation analysis for the C7 gene and found two novel mutations; a point mutation at the 3'splice acceptor site of intron 4 (c.281-1G>T) and a large deletion mutation encompassing almost the whole C7 gene from exon 1 to exon 17 (c.1-?_2350+?del). A haplotype analysis showed that the large deletion mutation was inherited from the patient's father. To the best of our knowledge, this is the first confirmed case of C7 deficiency in Korea.

Portadores de Neisseria meningitidis en niños de una escuela primaria

Se realizó, con la autorización de la Dirección Municipal de Educación, Dirección Municipal de Salud y el consentimiento informado de los padres, un estudio transversal descriptivo en 318 niños de la Escuela "Mártires del Corynthia"; con el propósito de conocer la prevalencia de portadores de meningococo en niños de edad escolar, determinar los marcadores epidemiológicos de las cepas aisladas y establecer la posible relación existente entre el portador y las variables como edad, sexo, antecedente de infección respiratoria aguda, hacinamiento, amigdalectomía, efecto inhibitorio de la flora acompañante y el estado secretor de antígenos ABH en la saliva. A todos, se les tomó exudado nasofaríngeo y una muestra de saliva. Además, los padres llenaron una encuesta donde se indagó sobre los factores de riesgo a investigar. Se detectó 6,9 % de portadores de meningococo y predominaron las cepas NA:NT:P1.NST:L3,7,9. Los factores de riesgo que dieron resultados estadísticamente significativos respecto a la condición de portador de Neisseria meningitidis fueron: edad, antecedente de infección respiratoria aguda y la presencia de Streptococcus pneumoniae y Neisseria lactamica de la flora bacteriana acompañante en la nasofaringe de los niños investigados.

A cross-sectional and descriptive study was conducted among 318 children from the "Mártires del Corynthia" Primary School under the authorization of the Municipal Division of Education and the informed consent of their parents aimed at knowing the prevalence of meningoccoco carriers in school children, determining the epidemiological markers of the isolated strains and establishing the possible relation existing between the carrier and variables, such as age, sex, acute respiratory infection history, hacinamiento, amigdalectomy, inhibitory effect of of the accompanying flora and the secretory state of ABH antigens in saliva. All of them underwent nasopharyngeal exudate and a saliva sample was taken. In adition, the paents were surveyed about the risks factors to be investigated. 6.9 % of meningoccoco carriers were found and the NA:NT:P1:NST:L3,7,9 strains predominated. The risk factors with statistically significant results regarding the condition of carrier Neisseria meningitidis carrier were age, acute respiratory infection history, and the presence of Streptococcus pneumoniae and Neisseria lactamica of the accompanying bacterial flora in the nasopharynx of the children under study.