Clinical aspects and outcome of patients with swine flu among survivors and non-survivors

Background: Swine flu is an infective disease caused by any one of the several types of Influenza viruses. The world saw its first pandemic of swine flu this century in the year 2009 when the WHO raised a world-wide pandemic alert to level 6 on June 11, 2009. In India, first few cases (index cases) of swine flu were reported from Pune, Maharashtra. The most recent outbreak of this dreaded infection was reported during late winter of 2015.Methods: The present study was retrospective study. In order to collect the data, we reviewed medical charts of patients who were hospitalized in our hospital during the study period. Diagnosis of swine flu was confirmed after sending the blood-samples to Government approved laboratories in Pune and Mumbai. Real time, Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) method was employed for serological diagnosis. Forty-five confirmed cases of swine flu were included in this retrospective study. The primary objective of this study was to highlight the differences in the clinical profile as well as outcome between the patients who survived the attack of swine flu and those who did not.Results: Forty-five of these patients tested positive for H1N1 amounting to a positivity rate of 52.94%. Cough (93.3%) was the most common symptom followed by fever (88.8%) and breathlessness (82.2%). Patients who did not survive were more likely to have associated co-morbid conditions like Hypertension, Diabetes, cardio-vascular disease, pre-existing lung disease and pregnancy though this was not statistically significant ( p=0.189). Acute Respiratory Distress Syndrome (ARDS), Multi-Organ Dysfunction (MOD) and secondary bacterial infections were among the most common conditions that lead to death.Conclusions: Early detection of swine flu through meticulous screening in the community with a high index of suspicion followed by prompt and adequate treatment can go a long way in preventing another pandemic. Creating awareness among the lay people about personal as well as public hygiene is also vital to prevent the spread of this viral illness.

Distribution of phytoestrogenic diarylheptanoids and sesquiterpenoids components in Curcuma comosa rhizomes and its related species

Abstract Curcuma comosa Roxb., Zingiberaceae, a phytoestrogen-producing herb with vernacularly named "Wan Chak Mod Loog" in Thailand, has been traditionally used for treatment of gynecologic diseases and sold as food supplement in the market. However, similar rhizomes of its related species may lead to the confusion in the uses of this plant. This study was aimed to investigate the phytochemical constituents of different Curcuma spp. that used as "Wan Chak Mod Loog". Characteristic major compounds were isolated and identified. Phytochemical analysis of 45 Curcuma samples representing Curcuma sp., C. latifolia, and C. comosa were analyzed and compared with their phylogenetic relationship inferred by Amplified Fragment Length Polymorphism analysis. Phytoestrogen diarylheptanoids were found in all samples of C. comosa while sesquiterpenoids including hepatoxic zederone were found in C. latifolia and Curcuma sp. samples.

Homology modeling and application of 3 D structure of Cav1.2 channel / 中国药理学通报

Aim To construct 3 D structure model of cardiac Cav1.2 channel and check its accuracy and re-liability.Methods Homology model of Cav1.2 chan-nel α1 subunit was constructed using SWISS-MODEL server.The model was submitted to an online testing server built by University of California and scored by it.The binding of Cav1.2 channel with blocker or drug was simulated by MOE software molecular docking pro-gram to check the model′s accuracy and reliability.Re-sults Both the target sequence Cav1.2 α1 C and the template sequence Cav1.1 α1 S searched by SWISS-MODEL server belonged to L-type Ca2+channel.Since the homology was 7 1.5% revealed by sequence align-ment,homology modeling was performed using automa-ted mode.L-type Ca2+ channel blockers Verapamil, Nifedipine and Diltiazem could bind to the 3 D structure model of Cav1.2 channel,while sodium channel bloc-ker TTX could not.Furthermore,active ingredient of traditional Chinese drug Praeruptorin A and Berberine could also bind to the 3D structure model of Cav1.2 channel.Conclusion The 3 D structure model of Cav1.2 channel was constructed successfully,which provides reliable materials for further studies and estab-lishes the foundation for the application of homology modeling in the study of 3 D structure prediction of ion channels.

Temporal variation of normalized difference vegetation index (NDVI) and calculation of the crop coefficient (Kc ) from NDVI in areas cultivated with irrigated soybean / Variação temporal do Índice de Vegetação por Diferença Normalizada (NDVI) e obtenção do coeficiente de cultura (Kc ) a partir do NDVI em áreas cultivadas com soja irrigada

ABSTRACT: Vegetation indices obtained by remote sensing products have various applications in agriculture. An important application of the Normalized Difference Vegetation Index (NDVI) is obtaining the crop coefficient (Kc). The aims of this study were to analyze NDVI temporal profiles and to obtain Kc from the NDVI vegetation index product MOD13Q1. The analysis is based on the phenological stages of irrigated soybean crops in the municipality of Planura/MG during the 2010/2011 growing season. Areas planted with irrigated soybean were identified through fieldwork. Temporal series of the MOD13Q1 products were used to analyze NDVI, allowing the extraction of NDVI values for all points in the period studied. The NDVI temporal profiles showed a similar pattern to each other and corresponded to the crop cycle. The KcNDVI values for the MOD13Q1 products were well correlated to the FAO Kc values (r2=0.72). Thus, NDVI can be used as an alternative for obtaining crop coefficient (Kc).

RESUMO: Os índices de vegetação obtidos a partir de produtos de sensoriamento remoto apresentam várias aplicações na agricultura. Uma importante aplicação do índice de vegetação Normalized Difference Vegetation Index (NDVI) está relacionada à obtenção do coeficiente de cultura (Kc). Assim, o objetivo deste trabalho foi analisar os perfis temporais de NDVI e obter o Kc a partir do produto de índice de vegetação NDVI (MOD13Q1), baseado na análise dos estádios fenológicos da cultura de soja irrigada, no município de Planura/MG, safra 2010/2011. A identificação das áreas plantadas com soja irrigada foi feita através de pesquisa de campo. As séries temporais do produto MOD13Q1 foram utilizadas para analisar o NDVI, permitindo a extração dos valores de NDVI para todos os pontos no período estudado. Os perfis temporais de NDVI apresentaram um padrão semelhante entre si e quanto ao ciclo da cultura. Os valores de KcNDVI variaram, em média, de acordo com os valores de Kc FAO, representando uma correlação linear (r2) de 0,72 para o produto MOD13Q1. Assim, o NDVI pode ser usado como uma alternativa na obtenção do Kc.

Three scales in predicting prognosis of patients with heat stroke / 医学研究生学报

Objective The scale lists applied in the diagnosis and treatment of heat stroke generally draw on other specialty scales, and there is no specific scoring system on heat stroke verified by large-scale clinical trials.The paper compared common acute physiology and chronic health evaluationⅡ( APACHEⅡ) , dissolved inorganic carbon score( DIC score) , multiple organ dysfunction score( MOD score) for the prognostic evaluation of heat stroke patients, the sum of three scores and the sum of the percentages of three scores to the score sum on prognostic evaluation of heat stroke patients in order to find a scoring method with higher clinical value. Methods APACHEⅡ, MOD score, DIC score, the sum of three scores and the sum of three scores were applied on 43 patients with heat stroke admitted in our neurological intensive care unit ( NICU) or in intensive care unit ( ICU) .The analysis of the area under the receiver operating characteristic ( ROC) curve( AUC) analysis was made among five scores. Results The weighted sum of three scores has the largest AUC ( 0.896 ) in predicting the death of HS patients according to AUC.The optimal MOD score was 5.5 in predicting the death of HS with a sensitivity of 72.7%and a specifici-ty of 99.69%.The optimal DIC score was 1.5 in predicting the death of HS with a sensitivity of 100%and a specificity of 56.2%.The op-timal score of the sum of the percentages of three scores to the score sum was 0.727 in predicting the death of HS with a sensitivity of 72.7%and a specificity of 100%. Conclusion All the five scores can predict the prognosis of patients with heat stroke.However, due to the deficiency in the prognosis value, a more specific scoring system needs to be developed.

Estudo do desperdício de alimentos em um restaurante popular de Belém - PA: foco na sustentabilidade e qualidade de vida

Desperdício, segundo o dicionário Aurélio, é a "ação de perder-se totalmente, ato ou efeito de desperdiçar, esbanjamento, desbaratamento, restos, refugos, sobras". Este estudo teve por objetivo observar e analisar o índice de desperdício de alimentos na forma de sobras limpas e restos, em um Restaurante Popular da região metropolitana de Belém-PA, bem como promover a discussão da relação entre a sustentabilidade, o acesso à alimentação e a produção de refeições em UPR's. A coleta dos dados foi realizada no período de outubro a dezembro de 2012, durante 10 dias de cada mês, totalizando 30 dias. Realizaram-se os cálculos para verificar o quantitativo de: sobras limpas (%); sobra por pessoa (kg); resto-ingesta (%) e resto-ingesta por pessoa (kg). Os resultados obtidos nesses cálculos foram considerados para a determinação do percentual de desperdício de alimentos na Unidade. Assim, os principais parâmetros de referência para sobras limpas e resto alimentar gerados em unidades produtoras de refeições apontaram para um grande desperdício de alimentos no restaurante.

Waste, according to the dictionary of the Portuguese language "Aurélio", is the "totally lost action, act or effect of wasting, wasting, rout, remnants, scraps, leftovers". This study aimed to observe and analyze the index of food waste in the form of leftovers and clean surplus, in a popular restaurant in Belém-Pará and also to promote the discussion about sustainability, access to food and production of meals at food service units. Data collection was conducted in the period October-December 2012, occurring within 10 days of each month, totaling 30 days. We carried out the calculations to verify the amount o]: clean leftovers (%); spare per person (kg), MOD-swallowing (%) and MOD-swallowing per person (kg). The results obtained from these calculations considered for the determination of the percentage of food waste in the unit. Thus, the main benchmarks for rest and food leftovers clean generated unit producing meals pointed to a huge waste of food in the restaurant.

Golpe de calor: a propósito de un caso clínico / Heat stroke. a case report

El golpe de calor es una entidad poco frecuente y subdiagnosticada. La elevación de la temperatura corporal es la que desencadena las disfunciones metabólicas que pueden incluso llevar a la muerte. Se presenta el caso de un militar que se encontraba realizando ejercicios de infantería, durante el mes de septiembre, en días donde se produjeron condiciones climáticas extremas y desarrolla un cuadro de Disfunción Orgánica Múltiple (DOM) primaria; fue llevado al Servicio de Emergencia del Hospital de Fray Bentos, Río Negro. La evolución inicial se caracterizó por deterioro de la función neurológica, respiratoria, necesidad de ventilación mecánica, falla renal aguda y disfunción hematológica; se establecieron los diagnósticos de golpe de calor, injuria renal, rabomiólisis, insuficiencia respiratoria aguda y coagulación intravascular diseminada (CID). A pesar del tratamiento y manejo de sostén tiene una mala evolución, falleciendo a las 48 horas del ingreso. El caso nos recuerda que la exposición a condiciones de calor por arriba de la temperatura corporal, deteriora los mecanismos de control de calor corporal y metabólico. Es necesario un diagnóstico rápido y un manejo de sostén para conseguir una evolución satisfactoria.

A heat stroke is a very rare and under diagnosed entity. The rise in the body’s temperature is the element that triggers the metabolic dysfunctions that can even lead to death. A case of a soldier is presented; this soldier was training, doing his infantry exercises routine, during September, in days were extreme climate situations were happening, installing a case of primary Multiple Organ Dysfunction (MOD) syndrome. The soldier was taken to the Emergency Service in Fray Bentos’ Hospital, in Rio Negro. The initial evolution was clumsy and slowly, and the neurologic and breathing functions were worsening, with acute renal failure, and also hematological dysfunction. In addition to this, the patient was in need of mechanic ventilation. The diagnosis of temperature shock, acute renal injury, Rhabdomyolysis, acute respiratory failure and disseminated intravascular coagulation (DIC) were established. Supportive care was given to the patient, with an un satisfactory development, leading to death 48 hours after the hospital admission. This case reminds us that, the exposure to weather conditions that are over the body temperature interferes in the metabolism and the body’s mechanisms for controlling heat. A quick diagnosis and supportive care are needed in order to achieve a satisfactory evolution.

Experimental comparison of the antitussive and expectorant effects of seven traditional Chinese medicine compounds in mice / 中国实验动物学报

Objective In order to screen effective traditional Chinese medicine compounds to prevent and control porcine respiratory disease syndrome ( PRDC) , seven compound preparations of traditional Chinese medicine were tested and to analyze their antitussive and expectorant effects in mice .Methods Two hundred 6-week old ICR mice ( male∶fe-male=1∶1) were used in this study .Dextromethorphan and ammonium chloride were used as positive control drugs , and physiological saline was used as blank control .The antitussive and expectorant effects of the seven Chinese medicine com-pounds (groups 1, 2, 3, 4, 5, 6, 7) were observed by ammonia-induced cough model and tracheal phenol red secretion method in mice .Results The results showed that compounds 7 and 5 significantly prolonged the cough incubation period (P <0.05), and reduced the cough times within 5 min (P <0.05).Except for the group 4, tracheal phenol red excre-tion in the other groups was significantly lower than that of blank control group (P <0.05), and phenol red excretion in the mice of groups 7, 5 and ammonium chloride group was significantly lower than that in other treatment groups ( P <0.05).Conclusions The Chinese medicine compounds 5 and 7 show most evident expectorant effects , and worthy of fur-ther validation of them as a drug in the treatment of porcine respiratory disease syndrome .

Anamnesis de la anamnesis / Anamnesis of the anamnesis

El objetivo del trabajo es determinar el modelo médico hegemónico (MMH) o modelo biopsicosocial (MBPS) subyacente en cada capítulo de anamnesis de los libros de Semiología empleados para la enseñanza de grado en la Universidad de Buenos Aires en la Carrera de Medicina desde 1910 a la fecha. Se trata de un trabajo observacional descriptivo longitudinal retrospectivo que implicó la revisión de los capítulos sobre anamnesis donde se tomaron como variables de análisis la extensión absoluta y relativa del capítulo en relación al total de la obra y por otro lado, la indagación sobre aspectos psicosociales y la inclusión de la familia en calidad de recurso de salud de los pacientes. Con esas dos últimas variables se determinó la adherencia a uno u otro modelo. De una totalidad de 8 obras, solo una de ellas (la única cuya primera edición fue en el S. XXI) fue escrita bajo el MBPS, otra obra cuya...

To determine the hegemonic medical model (HMM) or biopsychosocial model (BPSM) underlying in each chapter of Anamnesisof Semiology books used for teaching in undergraduate at the Universityof Buenos Aires from 1910 to date. This is a retrospective, longitudinal observational study that involved the review of the chapters on Anamnesiswhere the variables of analysis taken were the absolute and relative lengthof the chapter in relation to the total work and on the other hand, the inquiry into psychosocial aspects and family inclusion as a health resourcefor patients. With these two last variables adherence to either model was determined. Out of 8 pieces, only one (the only one whose 'rst edition wasin the XXI century) was written under the MBPS, another work whose...

Comparación In Vitro de la adaptación marginal entre incrustaciones MOD maquinadas con el sistema IPS e: max CAD y restauraciones MOD en oro colado tipo III / valuation of marginal adaptation In Vitro of MOD fillings with an enamel finish manufactured with IPS e: max CAD (computer assisted design) and with gold type III

Objetivo: comparar la adaptación marginal In Vitro de incrustaciones MOD con terminación en esmalte fabricadas con IPS e.max CAD (Computer Asisted Desing) y fabricadas en oro tipo III. Materiales y métodos: En este estudio experimental exploratorio se uso una muestra no probabilística de 15 premolares sanos por cada uno de los dos grupos; IPS e.max CAD y oro tipo III.A todos los premolares se les realizó cavidades MOD estandarizadas para los 2 grupos. Los dientes preparados fueron asignados aleatoriamente a cada grupo. Las incrustaciones del grupo IPS e.max CAD fueron elaboradas con el sistema CEREC 3 y las incrustaciones en oro fueron elaboradas por los investigadores. Se tomaron estereo microfotografías de todas las muestras sobre papel milimetrado, y las imágenes fueron analizadas mediante el programa ImageTool. Se tomaron tres medidas adaptación marginal en el área proximal mesial o distal de cada muestra, que fueron promediadas y reportadas en micras. Los datos fueron analizados mediante ANOVA y Test de Mann-Whitney. Resultados: el 98% del total de las incrustaciones en oro y el 47% del total de las incrustaciones de IPS e.max CAD presentaron una adaptación marginal < a 120 micras. El promedio de desadaptación marginal del grupo IPS e.max CAD fue 122.8 μ + 44.1, mientras que para el grupo oro fue de 75.3 μ+42,6 encontrándose diferencias estadísticamente significativas entre los dos. Conclusiones: El oro reporta mejor adaptación marginal en restauraciones inlays MOD que los sistemas maquinados como el sistema IPS e.max CAD.

Objective: To compare In Vitro, the marginal adaptation of MOD fillings with an enamel finish manufactured with IPS e.max CAD (Computer Assisted Design) and those manufactured with gold type III. Materials and methods: In this exploratory experimental study, a non-probabilistic sample of 15 healthy premolars for each of the two groups (IPS e.max CAD and gold type III) was used. Standardized MOD cavities were made in all the premolars for both groups. The prepared teeth were randomly assigned to each group. The IPS e.max CAD fillings were made using the CEREC 3 system and the gold fillings were made by the researchers. Stereo microphotographs of all the samples were taken on millimeter paper and the images were analyzed using the Image Tool software. Three marginal adaptation measurements in the mesial proximal or distal area were taken for every sample; they were averaged and reported in microns. The data was analyzed using ANOVA and the Mann-Whitney test. Results: 98% of all the gold fillings and 47% of all the IPS e.max CAD fillings showed a marginal adaptation of less than or equal to 120 microns. The marginal unfitness average for the IPD e.max CAD group was 122.8 + 44.1 μm, and for the gold fillings group it was 75.3 + 42.6 μm. There was a statistically significant differences between the groups. Conclusions: Gold reports a better marginal adaptation for inlay MOD fillings than manufactured systems like IPS e.max CAD system.

Effect of one-time exhaustive exercise on individual' s mood states / 中华行为医学与脑科学杂志

Objective To study the changes of the mood states at different time point of one-time exhaustive exercise.Methods16 participants were tested by POMS at the moments before,at,after recovery and after recovery 20 min of one-time exhaustive exercise.Results The scores of the 7 subscales got by 4 measures were used for one-way repeated measures analysis of variance.The results were showed that tension subscale scores (F (3.45) =0.335,P＞0.05,ES =0.022),anger subscale scores (F(3.45) =3.683,P＞0.05,ES =0.197),fatigue subscale scores (F(3.45 =0.863,P＞0.05,ES =0.054),depression subscale scores (F(3.45) =1.905,P＞ 0.05,ES =0.113 ),confusion subscale scores (F( 3.45) =0.601,P ＞ 0.05,ES =0.039 ) and self-esteem subscale scores (F(3.45) =2.804,P ＞ 0.05,ES =0.157 ) had no significant differences,but vigor subscale scores increased significantly (F(3.45) =8.778,P ＜ 0.01,ES =0.369).Conclusion One-time exhaustive exercises enhanced individual' s positive mood states.

The Role of Blood Transfusion in HCV Infection: A Study Testing Ab: RNA & Genotype

Hepatitis C Virus (HCV) recently was identified as a major cause of post transfusion hepatitis world wide. To evaluate the role of blood transfusion on the prevalence of HCV infection, by testing antibody and RNA as well as the genotypes of HCV .Also to detect if Blood transfusion acts as unconfounding risk factor for HCV infection. Sera from 3491 pregnant women were investigated for the presence of HCV antibodies (anti-HCV) by using third generation enzyme immunoassay (EIA-3) as screening test, followed by immunoblot assay (Lia Tek-III). In addition 94 sera of studied women were subjected to molecular analysis (at laboratories of Sorin BioMedica – Italy) for the detection of viral RNA and genotypes of HCV. Using RT-PCR & DNA Enzyme immunoassay (DEIA) method. Our study revealed, that seroprevalence rate of HCV specific Ab & RNA were significantly higher (16.32 %, 80% respectively) among women with a history of blood transfusion, compared to those (2.53%, 56.5%) with no such history P=0.0001, P=0.01. And there is a significant direct linear correlation between number of blood transfused and the seropositive rate of anti-HCV(r=0.7, p=0.046). Based on multivariate analysis, interestingly, this study confirmed that, blood transfusion significantly acting as unconfounding risk factor for acquiring HCV infection (Adjusted OR=1.938,95% C.I=1.646-2.28). And the risk of exposure is increases with increased number of blood transfused. Although, we found no significant association between, HCV genotypic distribution and history of blood transfusion. However, high proportion of women with a history of blood transfusion were harboring HCV genotype –4 or 1b, 50%,40%, resepctively. Our study shows, evidence that, blood transfusion acts as unconfounding risk factor for acquiring and in a mode of transmission of HCV infection. Therefore strict screening of blood donor for HCV-Abs and / or RNA is highly recommended.

Aerobic and anaerobic decomposition of Pistia stratiotes leachates from a tropical eutrophic reservoir (Barra Bonita, SP, Brazil) / Decomposição aeróbia e anaerobia de lixiviados de Pistia stratiotes de um reservatório eutrófico tropical (Barra Bonita, SP, Brasil)

The present study discussed the kinetic aspects of leachate decomposition from an aquatic macrophyte, Pistia stratiotes L (water lettuce). This species was collected from Barra Bonita Reservoir located in the State of São Paulo (Brazil). Decomposition chambers were prepared with high molecular weight (HMW), low molecular weight (LMW) and integral (INT = HMW + LMW) dissolved organic matter (DOM) diluted with reservoir water. The samples were incubated at 20 °C, in darkness and under aerobic or anaerobic conditions. For 79 days, the concentrations of dissolved oxygen (DO) and organic carbon (OC) were measured. For calculating the deoxygenation coefficients (k d) and maximum oxygen consumption (COmax) the concentration of DO was integrated and fitted to a first-order kinetics model, which also applied to the depletion of OC concentrations. The COmax of INT incubations were 4 percent higher than the sum of HMW and LMW fractions. The deoxygenation coefficients, k d, had the same order of magnitude for all treatments. In relation to carbon decay, regardless of the availability of oxygen, the INT DOM also showed higher mineralisation. These results suggest that the leachate mineralisations are short-term processes; when the fractionation of the leachates occurs, the LMW had organic compounds with more accessibility for heterotrophic metabolism. On the other hand, when compared to INT DOM, the HMW and LMW were less consumed suggesting an interaction of the reactivity of the leachate. Our data suggest that in the Barra Bonita Reservoir the mineralisation of P. stratiotes leachates occurs through two competitive pathways (i.e. mineralisation of the labile compounds and formation of recalcitrant organic resources and their mineralisation) in which the oxygen availability and the molecular mass of DOM can interfere in the rates of reactions.

Nesse estudo foram discutidos aspectos cinéticos da decomposição de lixiviados da macrófita aquática Pistia stratiotes L (alface-d'água). A macrófita foi coletada no reservatório de Barra Bonita, localizado no Estado de São Paulo (Brasil). As câmaras de decomposição foram preparadas com amostras de água do reservatório e matéria orgânica dissolvida (MOD) de lixiviados com massa molecular alta (MMA), massa molecular baixa (MMB) e integral (INT = MMA + MMB). As amostras foram incubadas a 20 ºC, no escuro e sob condições aeróbias e anaeróbias. Durante 79 dias, as concentrações de oxigênio dissolvido (OD) e de carbono orgânico (CO) foram determinadas. Para os cálculos dos coeficientes de desoxigenação (k d) e das quantidades máximas de oxigênio consumido (OCmax), as concentrações de OD foram integradas e ajustadas a um modelo cinético de primeira ordem, que também foi empregado para os ajustes dos decréscimos das concentrações de CO. O OCmax da incubação com lixiviado integral (INT) foi 4 por cento maior que a soma dos OCmax das frações MMA e MMB. Os coeficientes de desoxigenação foram da mesma ordem de magnitude em todos os tratamentos. Em relação à perda de massa do carbono, independente da disponibilidade de oxigênio, a MOD INT apresentou as mineralizações mais elevadas. Os resultados sugeriram que as mineralizações desses lixiviados foram processos de curto prazo; na ocorrência de fracionamento, os lixiviados com MMB apresentam compostos orgânicos mais acessíveis aos metabolismos dos heterótrofos. Por outro lado, quando comparados com MOD INT, os lixiviados com MMB e MMA foram menos consumidos, sugerindo interação na reatividade dos lixiviados. Os resultados sugerem que no reservatório de Barra Bonita as mineralizações dos lixiviados de P. stratiotes ocorrem por duas rotas competitivas (i.e. mineralização dos compostos lábeis e formação de recursos refratários e sua mineralização), nas quais a disponibilidade de oxigênio e a massa molecular...

Reinforcement Effect Of Polyethylene Fiber In Root Filled Mandibular Molar: An Invitro Comparative Evaluation Of Two Different Techniques Of Placement .

Endodontic therapy, today, forms an integral part of everyday dental practice. The large number of teeth being treated endodontically makes it imperative for the dentists to provide satisfactory restoration for those teeth to remain intact within the dental arch as an integral functioning component. So this study was carried out to check the reinforcement of composite with polyethylene fibers placed in two different technique in root filled mandibular molar teeth with mesio-occlusodistal tooth preparation. Fifty freshly extracted molars were divided into five groups of ten teeth each. Group I: Intact teeth (positive control). Group II: Unrestored MOD prepared tooth (negative control). Group III: MOD tooth preparation restored with posterior composite resin. Group IV: Ribbond fiber was placed over the composite resin restoration and exposed fiber was covered with composite resin. Group V: Ribbond fiber was placed on the floor of the tooth preparation and the remaining prepared tooth was restored with composite resin restoration. The samples were subjected to compressive loading on Hounsfield tensometer until failure. The data were recorded and subjected to statistical analysis. Group-IV showed significantly higher fracture resistance than Group-V.

Effect of nitrogen availability on the oxygen consumption during mineralization of Scirpus cubensis from Infernão Lagoon (São Paulo-Brazil) - DOI: 10.4025/actascibiolsci.v29i2.524 / Efeito da disponibilidade de nitrogênio no consumo de oxigênio durante a mineralização de Scirpus cubensis da Lagoa do Infernão (São Paulo, Brasil) - DOI: 10.4025/actascibiolsci.v29i2.524

This study evaluated the influence of nitrogen additions in the oxygen uptake during decomposition of Scirpus cubensis, through laboratory assays. The dissolved oxygen, pH, electrical conductivity (EC) and water temperature were measured. The results showed an initial acidification that decreased gradually, indicating great release of reduced organic matter and subsequent CO2 formation. The decomposition chambers with greater nitrate concentrations exhibited higher pH mean values. The temporal variation of EC showed a small increase and an abrupt increase with increasing nitrate concentrations. The maximum oxygen uptake increased up to 6.37 mg L-1 of nitrate, then decreased. The deoxygenation rate showed an opposite trend from that observed for the oxygen uptake. The coefficients and maximum oxygen consumption related to the particulate detritus mineralization tended to increase with increasing nitrate concentration. The increase in nitrate levels affected the decomposition of each organic matter fraction in different ways, with the particulate organic matter being more easily degraded in richer nitrate concentrations than the dissolved organic matter.

Neste estudo, avaliou-se a influência de adições de nitrogênio no consumo de oxigênio durante a decomposição de Scirpus cubensis, por meio de ensaios de laboratório. Foram determinados: as concentrações de oxigênio dissolvido, o pH, a condutividade elétrica e a temperatura da água. Os resultados mostraram acidificação inicial que diminuíram gradualmente, indicando grande liberação de matéria orgânica reduzida e formação subseqüente de CO2. As câmaras de decomposição com maiores concentrações de nitrato apresentaram valores de pH mais alto. A condutividade elétrica mostrou pequeno incremento com o passar do tempo e aumento abrupto com a intensificação das concentrações de nitrato. O consumo de oxigênio máximo global aumentou até a concentração de nitrato de 6,37 mg L-1, depois decresceu. Os coeficientes globais de consumo de oxigênio apresentaram uma tendência oposta às quantidades máximas de oxigênio consumido. Os coeficientes de consumo de oxigênio, relacionados com a mineralização das frações particuladas, tenderam a aumentar com a elevação da concentração de nitrato. O aumento do nível de nitrato afetou diferentemente a decomposição das frações da matéria orgânica; a matéria orgânica particulada foi mais facilmente degradada do que a dissolvida em presença de maiores concentrações de nitrato.

Hypoglycemic Effects of Yifusheng on Experimental Animals with Hyperglycemia / 中药新药与临床药理

Hypoglycemic effects of Yifusheng on hyperglycemia animals induced by alloxan or adrenaline were studied.The result showed that Yifusheng in the dosage of 0.25 g/kg and 0.125 g/kg could significantly decrease the content of plasma blood sugar(P

RELATIONSHIP BETWEEN DEGREE OF INVASION AND TUMOR METASTASIS / 中国癌症杂志

PURPOSE To provide evidence for the relationship between degree of invasion and tumor metastasis. The tumor cells of transplantable mouse histiocytic sarcoma (L1) were inoculated at the right hind footpads of inbred 615-strain mice. METHODS Once bearing the tumor, all the mice were sacrificed respectively on the 1st. 3th, 5th. 10th, 20th, 30th, and 40th day as to observe the degree of tumor invasion and the process of tumor metastasis. RESULTS When the degree of tumor invasion was grade Ⅲ or Ⅳ , the metastasis of tumor cells was found earliest in draining lymph nodes. However, the tumor metastasis in lung appeared later than in lymph nodes. CONCLUSION According to the time of tumor growth and degree of invasion and metastasis, the authors suggest a new classification for cancer staging, namely, latent, invasive and metastatic stages. During the stage of tumor invasion, it is redivided into early, middle and late invasive phases. During the stage of tumor metastasis, it is redivided into early, middle and late metastatic phases.

Acute Respiratory Distress Syndrome in Respiratory Intensive Care Unit / 결핵

BACKGROUND: Patients with established ARDS have a mortality rate that exceeds 50 percent despite of intensive care including artificial ventilation modality. Mortality has been associated with sepsis and organ failure preceding or following ARDS ; APACHE ll score ; old age and predisposing factors. Revised ventilator strategy over last 10 years especially at ARDS appeared to improve the mortality of it. We retrospectively investigated 40 ARDS patients of respiratory-care unit to examine how these factors influence outcome. METHODS: A retrospective investigation of 40 ARDS patients in respiratory-care unit with ventilator management over 46 months was performed. We investigated the clinical characteristics such as a risk factor, cause of death and mortality, and also parameters such as APACHE ll score, number of organ dysfunction and hypoxia score (HS, PaO2/FIO2) at day 1, 3, 7 of severe acute lung injury, and simultaneously the PEEP level and tidal volume. RESULTS: Clinical conditions associated with ARDS were sepsis 50%, pneumonia 30%, aspiration pneumonia 20%, and mortality rate based on the etiology of ARDS was sepsis 50%, pneumonia 67% (p 70), APACHE ll score( > 26), HS(< 150) at day 1 of ARDS, there were significant differences between 28-days survivor and nonsurvivors(p<0.05). After day 1 of ARDS, the survivors have improved their APACHE ll score, HS, numbers of organ dysfunction over the first 3d to 7d, but nonsurvivors did not improve over a seven-day course. There were significant differences in APACHE II score and numbers of organ dysfunction of day 3, 7 of ARDS, and HS of day 7 of ARDS between survivors and nonsurvivors(p<0.05). Fatality rate of ARDS has been declined from 68% to less than 40% between 1995 and 1998. There were no differences in APACHE ll score, HS, numbers of organ dysfunction, old age at presentation of ARDS. In last years, mean PEEP level was significantly higher and mean tidal volume was significantly lower than previous years during seven days of ARDS(p<0.01). CONCLUSIONS: Improvement of HS, APACHE ll score, organ dysfunction over the first 3d to 7d is associated with increased survival. Decline in ARDS fatality rates between 1995 and 1998 seems that this trend must be attributed to improved supportive therapy including at least high PEEP instead of conventional-least PEEP approach in ventilator management of acute respiratory distress syndrome.

APPROACHES TO MINIMALLY INVASIVE TREATMENT OF LIVER CANCER / 解放军医学杂志

Minimally invasive treatment of liver cancer plays a very important role in clinical practice in China, because most patients had the background of hepatitis or cirrhosis and were prone to recurrence after radical resection of the tumor. In the past four decades, much progress has been made in controlling liver cancer, which is well consistent with the trends of minimally invasive treatment. Minimally invasive therapy is also the main goals of our practice and has a great potential developing future, although a good outcome is the prerequisite. Nowadays, minimally invasive treatment for liver cancer includes percutaneous transarterial chemotherapy or embolization (TAE or TACE), percutaneous ethand injection (PEI), and ablation with radiofrequency, micromave, cryosurgery or high intensity focused ultrasound.

EFFECT OF MAGNESIUM SUPPLEMENTATIO N ON OXIDATIVE MODIFICATION OF HUMAN LOW DENS ITY LIPOPROTEIN / 营养学报

Objective: The effects of magnesium on the oxidation of low density lipoprotein (LDL) were systematically investigated by two different oxidation systems. Methods: LDLs were isolated from pooled healthy human fresh sera by ultracentrifugation. Oxidation of LDL was induced by adding Cu 2+ or co-cultured with cultured human umbilical vein endothelial cells. Conjugate diene was measured to assess the susceptibility of LDL to oxidation. The extent of LDL modification was determined by measuring the formation of thiobarbituric acid reaction substances (TBARS). Results: (1)The presence of Mg 2+ resulted in a protracted lag phase at doses of 0.3 mmol/L, 0.6 mmol/L, 1.2 mmol/L, and 2.4 mmol/L, as well as decreased production of TBARS when LDL was oxidized by the addition of Cu 2+ , at doses of 0.3 mmol/L and 0.6 mmol/L Mg 2+ .(2)Treatment of LDL with Mg 2+ (0.3 mmol/L, 0.6 mmol/L, 1.2 mmol/L, and 2.4 mmol/L) reduced the production of TBARS during endothelial cell-mediated LDL oxidation, P