Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population / 生物医学与环境科学（英文）

OBJECTIVE@#The association between neutrophil-to-lymphocyte ratio (NLR) with subclinical macrovascular and microvascular diseases has been less investigated. We sought to examine the association between NLR and new-onset subclinical macrovascular and microvascular abnormalities in the Chinese population.@*METHODS@#From a community cohort, we included 6,430 adults aged ≥ 40 years without subclinical macrovascular and microvascular diseases at baseline. We measured subclinical macrovascular and microvascular abnormalities separately using the ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and albuminuria.@*RESULTS@#During a mean follow-up of 4.3 years, 110 participants developed incident abnormal ABI, 746 participants developed incident elevated baPWV, and 503 participants developed incident albuminuria. Poisson regression analysis indicated that NLR was significantly associated with an increased risk of new-onset abnormal ABI, elevated baPWV, and albuminuria. Compared to overweight/obese participants, we found a much stronger association between NLR and subclinical vascular abnormalities in participants with normal weight. Furthermore, we found an interaction between the NLR and body mass index (BMI) on the risk of new-onset abnormal ABI ( P for interaction: 0.01).@*CONCLUSION@#NLR was associated with subclinical macrovascular and microvascular diseases in the Chinese population. Furthermore, in participants with normal weight, the association between NLR and subclinical vascular abnormalities was much stronger.

A Study Of Pulmonary Function Tests In Type 2 Diabetes Mellitus Patients Of Sub-Himalayan Plain Area Of Darjeeling District.

BACKGROUND: Diabetes mellitus is one of the most common endocrine and metabolic disorders. It is fifth in ranking as a leading cause of death worldwide and is responsible for almost 3 million deaths annually. Chronic hyperglycemia and related metabolic derangements are mainly associated with secondary damage in multiple organ systems, especially kidneys, eyes, nerves and blood vessels. Pulmonary functions in diabetes mellitus have been studied frequently in many countries other than India, while in our country, there are few studies concerning these abnormalities and their relationship with the disease. OBJECTIVES:To determine and compare the lung function test between type 2 diabetic patients with normoglycemic control group. MATERIALS AND METHODS: This is a prospective observational cross sectional study. This study was carried out in North Bengal Medical College and Hospital in Department of Physiology and Department of Medicine. A total number of 215 subjects were included in this study . Among them, 106 subjects who suffered from type 2 diabetes mellitus for >5 year duration were included in Group A (study group) and 109 normoglycemic subjects were included in Group B – (control group). The spirometer parameters (FVC, FEV1, PEFR, FEV1/FVC) of participants of both groups were evaluated and compared. RESULTS: We have found that all of the spirometric parameters, except FEV1/FVC ratio were significantly lower in the type 2 diabetes mellitus patients than the control group. FEV1/FVC ratio was lower in study group than control group, but the reduction in study group was not statistically significant (Pvalue >0.05). CONCLUSION: The present study is revealing that, type 2 diabetes mellitus, being a systemic disease, also affects lungs and causes restrictive type of ventilatory changes on long duration hyperglycemia.