Effectiveness of Molecular?Targeted Chemotherapy in Ameloblastomas: A Systematic Review

Ameloblastoma is a benign, locally aggressive neoplasm that needs extensive surgical resection. The goal of this article is to obtain an in?depth review of benign ameloblastomas to determine the available level of evidence and the possible benefit of targeted therapeutics for the treatment of ameloblastoma and BRAF V600E mutation in ameloblastoma. An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE, EBSCO, and Web of Science for eligible studies published between 1975 and 2021. The systematic review is registered with INPLASY (INPLASY202260018). The review included 2 case series and 17 case reports. The histopathological type, anatomic location, expression of BRAF mutation, additional mutations, and molecular?targeted therapies of the 19 reviewed articles were summarized and tabulated. Interestingly, the majority of the primary site of ameloblastoma was located in the mandible (80.9%) compared to the maxilla (17%). The tumour size was reported in nine of the included studies. Most of the included studies in the review exhibited ameloblastoma with BRAF V600E mutations and responded to molecular?targeted therapies. Molecular therapies employing BRAF and/or MEK inhibitors in ameloblastoma with BRAF V600E mutations proved to be an appropriate treatment based on the limited available evidence. It is essential further to deepen our understanding at th

O trabalho de empregada doméstica e seus impactos na subjetividade / Pthe work of maid and its impacts on subjectivity / El trabajo de empleada doméstica y sus impactos en la subjetividad

Este artigo apresenta o contexto histórico do surgimento da categoria da empregada doméstica, seu perfil sociodemográfico e as leis que regulamentam essa ocupação, no Brasil. Trata-se de uma pesquisa basicamente qualitativa, que partiu dos estudos de Le Guillant, relativos à “condição de empregada doméstica”. O levantamento de dados baseou-se em entrevistas semiestruturadas com oito empregadas domésticas residentes em Belo Horizonte. Apesar das lutas da categoria e dos avanços legais que regulamentaram a profissão, com a Lei Complementar nº 150/2015, constatou-se que o trabalho doméstico ainda é fonte de ressentimentos e humilhações. Os depoimentos das participantes evidenciam os impactos negativos sobre sua subjetividade, já que a profissão é ainda objeto de estigmatização e discriminação, por parte dos empregadores e da sociedade

This article presents the historical context of the emergence of maid category, its sociodemographic profile and the laws that regulate this occupation in Brazil. This is basically a qualitative research that began in Le Guillant studies on “maid condition “. The data collection was based on semi-structured interviews with eight maids living in Belo Horizonte. Despite the fights of the category and the legal advances that regulate the profession, with the Law 150/2015, it was found that maid job is still a source of resentments and humiliations. The participants statements show the negative impacts on their subjectivity, since the profession is still subject of stigmatization and discrimination, by the employers and by the society

El objetivo de este artículo es mostrar el contexto histórico del surgimiento de la clase de la empleada doméstica, su perfil sociodemográfico y las leyes que regulan esa ocupación, en Brasil. Se trata de una investigación básicamente cualitativa, que partió de los estudios de Le Guillant, relativos a la “condición de empleada doméstica”. Los datos fueron levantados por medio de entrevistas semiestructuradas con ocho empleadas domésticas residentes en Belo Horizonte. A pesar de las luchas de la clase doméstica y de los avanzos legales que reglamentaron la profesión, con la Ley Complementaria nº 150/2015, se constató que el trabajo doméstico todavía es fuente de resentimientos y humillaciones. Los testimonios de las participantes evidencian los impactos negativos sobre su subjetividad, ya que la profesión es todavía objeto de estigmatización y discriminación, por parte de los empleadores y de la sociedad

Therapeutic Effect of Jade Maid Decoction for Experimental Periodontitis in Rabbits / 广州中医药大学学报

Objective To observe the therapeutic effect of Jade Maid Decoction(JMD),a Chinese herbal prescription for nourishing yin and clearing stomach-heat,on experimental periodontitis.Methods Twenty-four New Zealand rabbits were randomized into the model group,JMD group(oral use of JMD 23 g?kg-1?d-1),external application group(periodontal injection of minocycline hydrochloride ointment 50mg),and the combination group(oral use of JMD and periodontal injection of minocycline hydrochloride ointment).Experimental periodontitis was induced by ligation method.The treatment lasted 6 weeks.Gingival bleeding on probing(BOP) and probing pocket depth(PPD) were detected each week after medication,and pathological examination of the mandible was used to confirm the therapeutic effect after treatment.Results Gingival BOP was reduced to various degrees at different time in the three medication groups,and the effect was obvious in the combination group;PPD was also decreased to various degrees,and the difference of PPD between the three medication groups and the model group was significant after treatment for 4 weeks(P