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1.
Medisan ; 28(1)feb. 2024.
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1558498

RESUMO

Introducción: La enuresis nocturna es un motivo frecuente de consulta en pediatría, psiquiatría infantil, psicología y medicina familiar, con mayor porcentaje en los niños de 5 años de edad, seguidos por los de 7 y 9, en ese orden. Objetivo: Determinar la validez de constructo del algoritmo hipnoterapéutico para pacientes con enuresis nocturna monosintomática. Métodos: Se realizó una investigación compleja de 97 pacientes, atendidos en la Clínica de Hipnosis Terapéutica de la Universidad de Ciencias Médicas de Santiago de Cuba, desde febrero del 2021 hasta julio del 2022, la cual estuvo estructurada en 3 etapas metodológicas de validación de constructo para dar continuidad a la etapa IV de la validación de contenido del algoritmo hipnoterapéutico, sobre la base de 2 cuasi-experimentos sin grupo de control y un estudio cuasiexperimental con grupo de control no equivalente de la segunda etapa de dicha investigación. Resultados: El análisis factorial sobre el estudio de componentes principales fue factible, pues los factores 1, 2 y 3 debían mantenerse, lo cual se expresó en el gráfico de sedimentación y en la varianza total explicada, a través de los porcentajes acumulados en los autovalores iniciales y la suma de las saturaciones al cuadrado de la extracción y la rotación con 64,24 %. Conclusiones: La validación de constructo del algoritmo diseñado mostró pertinencia, dada por la idoneidad del análisis factorial y la prueba de esfericidad de Bartlett.


Introduction: Bedwetting is a frequent reason to visit pediatric, infant psychiatry, psychology and family medicine services, with more percentage in 5 years children, followed by 7 and 9 years children, in that order. Objective: To determine the construct validity of the hypnotherapeutic algorithm for patients with monosymptomatic bedwetting. Methods: A complex investigation of 97 patients was carried out, who were assisted in the Therapeutic Hypnosis Clinic of the University of Medical Sciences in Santiago de Cuba, from February, 2021, to July, 2022 which was structured in 3 methodological phases of construct validation to continue the phase IV of hypnotherapeutic algorithm content validation, on the base of 2 quasi-experiments without control group and a quasi-experiment with non equivalent control group of the second phase of this investigation. Results: The factorial analysis on the study of main components was possible, because the factors 1, 2 and 3 should stay, which was expressed in the sedimentation graph and in the explained total variance, through the percentages accumulated in the initial auto values and the sum of saturations to the square of extraction and rotation with 64.24%. Conclusions: The construct validation of the designed algorithm showed relevancy, given by the suitability of the factorial analysis and the Bartlett test of spherical form.

2.
China Pharmacy ; (12): 921-926, 2021.
Artigo em Chinês | WPRIM | ID: wpr-876260

RESUMO

OBJECTIVE:To establish the method for the content det ermination of 4 components in Forsythia suspensa flowers by drying in shade ,vacuum freeze-drying ,oven(30,50,70 ℃)and sun ,so as to evaluate the effects of different drying methods on the main components of F. suspensa flowers and screen the optimal drying method. METHODS :UPLC method was adopted. The determination was performed on Waters ACQUITY UPLC BEH C 18 column with mobile phase consisted of acetonitrile- 0.1% phosphoric acid aqueous solution (gradient elution )at the flow rate of 0.3 mL/min. The detection wavelength was set at 230 nm, and column was 35 ℃. The sample size was 1 μL. Euclidean closeness(C)i of different drying methods was calculated by TOPSIS comprehensive analysis method ,and the optimal drying method was defined. RESULTS :The linear range of forsythiaside A , rutin,forsythin,(+)-pinoresinol-4-O-β-D-glucopyranoside were 0.007 5-0.037 7,0.027 4-0.137 2,0.001 9-0.009 5,0.005 6-0.028 8 µg(all r>0.999). RSDs of precision ,stability(32 h)and reproducibility tests were all lower than 2%. The recoveries were 97.27%-102.53%,100.53%-104.11%,98.45%-104.02%,98.66%-104.82%,respectively;and all RSDs <3%(n=3). The contents were 1.645 8-4.987 9,11.730 2-20.978 0,0.875 5-2.005 0,2.366 0-5.535 7 mg/g. The content of forsythiaside A was the highest after drying at 30 ℃,rutin and (+)-pinoresinol-4- O-β-D-glucopyranoside were the highest after vacuum freeze-drying,forsythiaside was the highest after drying at 50 ℃ . Results of TOPSIS analysis showed that Ci of F. suspensa flowers by drying in shade ,vacuum freeze-drying ,oven(30,50,70 ℃)and sun were 0.079 9,0.553 5,0.495 4, 0.503 8,0.157 9,0.217 2,respectively;the order of Ci was vacuum freeze-drying > 50 ℃ oven drying > 30 ℃ oven drying>sun drying >70 ℃ oven drying > shade drying. CONCLUSIONS:Established method is simple ,reproducible and can be used for the content determination of 4 components in F. suspensa flowers. The samples are preferably dried by vacuum freeze-drying,followed by 50 ℃ oven drying ,30 ℃ oven drying , and then dried in the sun and oven at 70 ℃ and finally in the shade.

3.
Acta Pharmaceutica Sinica ; (12): 2854-2861, 2020.
Artigo em Chinês | WPRIM | ID: wpr-862284

RESUMO

With the in-depth study of related substances and the development of consistency evaluation of generic drugs, relative correction factors are gaining increasing attention. By analyzing the domestic and foreign literature on correction factors in recent years, this paper describes the correction factor component, the current measurement method and its application. The rules and key points of use of an impurity correction factor and its determination and application are described, and some problems in its determination and application are discussed, providing a reference and basis for the standardization of research on impurity correction factors in the future.

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