Protocol for a systematic mapping review of surgical and pharmacological interventions for the treatment of trigeminal neuralgia / Protocolo de mapeo sistemático de intervenciones quirúrgicas y farmacológicas en el tratamiento de la neuralgia trigeminal

Introduction Trigeminal neuralgia is a painful neuropathic disorder characterized by sudden electric shock­like pain that significantly impacts patients' quality of life. Multiple treatment alternatives are available, including medical and surgical options but establishing the optimal course of action can be challenging. To enhance clinical decision-making for trigeminal neuralgia treatment, it is imperative to organize, describe and map the available systematic reviews and randomized trials. This will help identify the best treatment alternatives supported by evidence and acknowledge potential knowledge gaps where future research is needed. Objective This systematic mapping review aims to provide up-to-date evidence on the different surgical and pharmacological treatment alternatives used for trigeminal neuralgia. Methods A search will be systematically conducted on the Epistemonikos database to identify potentially eligible systematic reviews. Additionally, a search will be made in PubMed, CENTRAL, and EBSCO to identify randomized controlled trials assessing pharmacological and surgical treatment interventions for trigeminal neuralgia. Two independent reviewers will screen and select the studies. Data on the different treatment alternatives and reported outcomes in the included studies will be extracted using standardized forms. Following extraction, descriptive statistical methods will be used to analyze the data. The final output of this study will include an evidence map that will illustrate the connections between different treatments and their respective outcomes, providing a clear depiction of the evidence landscape. Expected results This study expects to map, describe and assess the methodological quality of the available systematic reviews and trials on pharmacological interventions and neurosurgical procedures for treating trigeminal neuralgia. It will present the results in an evidence map that organizes the available evidence based on their different interventions and outcomes. This evidence map will serve as a visual tool to assist healthcare professionals and patients to understand evidence-based treatment options and their implications for managing this medical condition.

Introducción La neuralgia del trigémino es un trastorno neuropático doloroso caracterizado por un dolor súbito y agudo, similar a una descarga eléctrica, que impacta significativamente en la calidad de vida. Dada la variedad de tratamientos disponibles, médicos y quirúrgicos, es crucial organizar y mapear la evidencia proveniente de revisiones sistemáticas y ensayos clínicos para orientar las decisiones clínicas. Esto permite identificar tratamientos respaldados por evidencia y señalar áreas de investigación futura. Objetivo El propósito de esta revisión sistemática de mapeo es proporcionar una visión actualizada de la evidencia existente en relación con las diversas opciones de tratamiento quirúrgico y farmacológico empleadas en el manejo de la neuralgia del trigémino. Métodos Se realizará una búsqueda sistemática en la base de datos Epistemonikos para identificar potenciales revisiones sistemáticas. Adicionalmente, se buscará en PubMed, CENTRAL y EBSCO ensayos clínicos aleatorizados que evalúen intervenciones de tratamiento farmacológico y quirúrgico para la neuralgia del trigémino. Dos revisores independientes cribarán y seleccionarán los estudios. Se extraerán datos sobre las diferentes alternativas de tratamiento y los resultados reportados en los estudios incluidos utilizando formularios estandarizados. Tras la extracción, se utilizarán métodos estadísticos descriptivos para analizar los datos. El producto final de este estudio incluirá un mapa de evidencia que ilustrará las conexiones entre los diferentes tratamientos y sus respectivos resultados, proporcionando una representación clara del panorama de la evidencia. Resultados esperados Los resultados que se extraerán de este mapeo sistemático incluyen identificar y describir las diferentes alternativas, tanto farmacológicas como quirúrgicas, que existen para el tratamiento de la neuralgia del trigémino. Además, se planea presentar un mapa de evidencia que se basará en los ensayos clínicos aleatorizados y revisiones sistemáticas, el cual mostrará la evidencia de manera organizada entre las diferentes intervenciones y sus desenlaces. Este mapa de evidencia servirá como una herramienta visual que ayudará a los profesionales de la salud y los pacientes a comprender mejor las opciones de tratamiento respaldadas por la evidencia y sus consecuencias en el manejo de esta condición médica.

Mapeamento do Potencial da Superfície Corporal durante a Despolarização Ventricular em Atletas com Intervalo PQ Prolongado após Exercício / Body Surface Potential Mapping during Ventricular Depolarization in Athletes with Prolonged PQ Interval after Exercise

Resumo Fundamento: O prolongamento do intervalo PQ, geralmente associado a um atraso na condução atrioventricular, pode estar relacionado a alterações na propagação do impulso intraventricular. Objetivo: Avaliar, por meio do mapeamento do potencial de superfície corporal (BSPM), o processo de despolarização ventricular em atletas com intervalos PQ prolongados em repouso e após o exercício. Métodos: O estudo incluiu 7 esquiadores cross-country com intervalo PQ superior a 200 ms (grupo PQ Prolongado) e 7 com intervalo PQ inferior a 200 ms (grupo PQ Normal). O BSPM de 64 derivações unipolares do tronco foi realizado antes (Pré-Ex) e após o teste ergométrico de bicicleta (Pós-Ex). Mapas equipotenciais da superfície corporal foram analisados durante a despolarização ventricular. O nível de significância foi de 5%. Resultados: Comparado com atletas com PQ Normal, o primeiro e o segundo períodos de posição estável dos potenciais cardíacos na superfície do tronco foram mais longos, e a formação da distribuição de potencial "sela" ocorreu mais tarde, no Pré-Ex, nos atletas com PQ Prolongado. No Pós-Ex, o grupo PQ Prolongado apresentou um encurtamento do primeiro e segundo períodos de distribuições de potencial estáveis e uma diminuição no tempo de aparecimento do fenômeno "sela" em relação ao Pré-Ex (para valores próximos aos do Normal -Grupo PQ). Além disso, no Pós-Ex, a primeira inversão das distribuições de potencial e a duração total da despolarização ventricular em atletas com PQ Prolongado diminuíram em comparação com o Pré-Ex e com valores semelhantes em atletas com PQ Normal. Em comparação com atletas com PQ Normal, a segunda inversão foi mais longa no Pré-Ex e Pós-Ex em atletas com PQ Prolongado. Conclusão: Atletas com PQ prolongado apresentaram diferenças significativas nas características temporais do BSPM durante a despolarização ventricular, tanto em repouso quanto após o exercício, em comparação com atletas com PQ normal.

Abstract Background: Prolongation of the PQ interval, generally associated with an atrioventricular conduction delay, may be related to changes in intraventricular impulse spreading. Objective: To assess, using body surface potential mapping (BSPM), the process of ventricular depolarization in athletes with prolonged PQ intervals at rest and after exercise. Methods: The study included 7 cross-country skiers with a PQ interval of more than 200 ms (Prolonged-PQ group) and 7 with a PQ interval of less than 200 ms (Normal-PQ group). The BSPM from 64 unipolar torso leads was performed before (Pre-Ex) and after the bicycle exercise test (Post-Ex). Body surface equipotential maps were analyzed during ventricular depolarization. The significance level was 5%. Results: Compared to Normal-PQ athletes, the first and second periods of the stable position of cardiac potentials on the torso surface were longer, and the formation of the "saddle" potential distribution occurred later, at Pre-Ex, in Prolonged-PQ athletes. At Post-Ex, the Prolonged-PQ group showed a shortening of the first and second periods of stable potential distributions and a decrease in appearance time of the "saddle" phenomenon relative to Pre-Ex (to the values near to those of the Normal-PQ group). Additionally, at Post-Ex, the first inversion of potential distributions and the total duration of ventricular depolarization in Prolonged-PQ athletes decreased compared to Pre-Ex and with similar values in Normal-PQ athletes. Compared to Normal-PQ athletes, the second inversion was longer at Pre-Ex and Post-Ex in Prolonged-PQ athletes. Conclusion: Prolonged-PQ athletes had significant differences in the temporal characteristics of BSPM during ventricular depolarization both at rest and after exercise as compared to Normal-PQ athletes.

Spatial patterns of prematurity and its determinants in the metropolitan region of São Paulo, Brazil, 2010-2019 / Padrões espaciais da prematuridade e seus determinantes na região metropolitana de São Paulo, Brasil, 2010-2019

ABSTRACT Objective: To analyze spatial distribution of preterm births and their association with maternal, social, and health services indicators in the metropolitan region of São Paulo, Brazil, 2010-2019. Methods: Ecological study using data on preterm newborns from 39 municipalities in the metropolitan region of São Paulo. Univariate global Moran's index (Im) was used to evaluate spatial association of prematurity, and univariate local Moran's index by using the cluster map (LISA) to identify spatial patterns and clusters. Bivariate global Moran's index was also used to analyze spatial autocorrelation with maternal, social, and health services indicators. Results: A total of 3,103,898 live births were registered in period 2010-2019, of which 331,174 (10.7%) were preterm. The global Moran's index showed spatial independence (Im=0.05; p-value=0.233) of the proportion of preterm births between municipalities. However, in the local spatial analysis it was possible to identify a statistically significant spatial cluster between the municipalities of Biritiba Mirim, Guararema and Salesópolis, with high proportions of preterm births. In the bivariate analysis, a significant positive spatial association was identified with proportions of mothers under 20 years old (Im=0.17; p-value=0.024) and mothers with low schooling (Im=0.17; p-value=0.020), and a significant negative spatial association with HDI (Im=-0.14; p-value=0.039). Conclusions: The local spatial approach identified a spatial cluster located in the far east of the metropolitan region of São Paulo, where actions by health managers are needed to minimize occurrence of preterm births.

RESUMO Objetivo: Analisar a distribuição espacial dos nascimentos prematuros e sua associação com indicadores maternos, sociais e de serviços de saúde na região metropolitana de São Paulo, Brasil, 2010-2019. Métodos: Estudo ecológico utilizando dados sobre recém-nascidos pré-termo dos 39 municípios da região metropolitana de São Paulo. Utilizou-se o índice de Moran (Im) global univariado para avaliar a associação espacial da prematuridade, e o índice de Moran local univariado por meio do mapa de clusters (LISA) para a identificação de padrões e aglomerados espaciais. Também foi utilizado o índice de Moran global bivariado para analisar a autocorrelação espacial com os indicadores maternos, sociais e de serviços de saúde. Resultados: Foram registrados 3.103.898 nascidos vivos no período 2010-2019, dos quais 331.174 (10,7%) foram prematuros. O índice de Moran global mostrou independência espacial (Im=0,05; p-valor=0,233) da proporção dos nascimentos prematuros entre municípios. No entanto, na análise espacial local foi possível identificar aglomerado espacial estatisticamente significativo entre os municípios de Biritiba Mirim, Guararema e Salesópolis, com proporções altas de nascimentos pré-termo. Na análise bivariada, identificou-se associação espacial significativa positiva com proporções de mães menores de 20 anos (Im=0,17; p-valor=0,024) e mães com baixa escolaridade (Im=0,17; p-valor=0,020), e associação espacial significativa negativa com IDH (Im=-0,14; p-valor=0,039). Conclusão: A abordagem espacial local identificou agrupamento espacial situado no extremo leste da região metropolitana de São Paulo, onde ações dos gestores de saúde são necessárias para minimizar a ocorrência de partos prematuros.

Temporal analysis and spatial distribution of acquired syphilis in the state of Mato Grosso, Brazil, 2010-2021: an ecological study / Análisis temporal y distribución espacial de la sífilis adquirida en el estado de Mato Grosso, 2010-2021: estudio ecológico / Análise temporal e distribuição espacial da sífilis adquirida no estado de Mato Grosso, 2010-2021: estudo ecológico

Abstract Objective: To analyze the temporal trend and the spatial distribution of acquired syphilis in Mato Grosso, Brazil, between 2010 and 2021. Methods: This was an ecological study using notifications of acquired syphilis held on the Notifiable Health Conditions Information System. Detection rates were calculated by health macro-region and three-year periods (2010-2012, 2013-2015, 2016-2018, 2019-2021). The jointpoint method was used to calculate annual percentage change (APC). Thematic maps of Bayesian rates were built and distribution was analyzed using Local Moran. Results: The detection rate increased from 16.2 per 100,000 inhabitants in the first three-year period (2010-2012) to 70.0 in the last three-year period (2019-2021). The Central-North macro-region had the highest rate in the last three years (94.3/100,000 inhab.), while the highest upward trend occurred in the Central-Northwest macro-region, from 2013 to 2018 (APC = 50.2; 95%CI 26.3;78.6). There was an increase in Bayesian rates in most municipalities. Conclusion: There was a trend towards an increase in acquired syphilis, especially in the last two three-year periods.

Resumen Objetivo: Analizar la tendencia temporal y la distribución espacial de la sífilis adquirida en Mato Grosso, de 2010 a 2021. Métodos: Estudio ecológico utilizando informes de sífilis adquirida del Sistema de Información de Enfermedades de Declaración Obligatoria - Sinan. Las tasas de detección se calcularon por macrorregión de salud y trienios (2010-2012, 2013-2015, 2016-2018, 2019-2021). Se utilizó el método jointpoint para calcular el cambio porcentual anual (CPA). Se construyeron mapas temáticos de tasas bayesianas y se analizó la distribución por Moran Local. Resultados: La tasa de detección aumentó de 16,2 por 100.000 en el primer trienio (2010-2012) a 70,0 en el último trienio (2019-2021). La macrorregión Centro-Norte presentó la tasa más alta en los últimos tres años (94,3/100.000 hab.), mientras que la mayor tendencia al alza se presentó en la macrorregión Centro-Noroeste, de 2013 a 2018 (CPA = 50,2; IC95% 26,3; 78,6). Hubo un aumento en las tasas bayesianas en la mayoría de los municipios. Conclusión: Hubo una tendencia al aumento de la sífilis adquirida, especialmente en los dos últimos trienios.

Resumo Objetivo: Analisar a tendência temporal e a distribuição espacial da sífilis adquirida em Mato Grosso, de 2010 a 2021. Métodos: Estudo ecológico utilizando notificações de sífilis adquirida do Sistema de Informação de Agravos de Notificação. As taxas de detecção foram calculadas por macrorregiões de saúde e triênios (2010-2012, 2013-2015, 2016-2018, 2019-2021). O método jointpoint foi utilizado no cálculo da variação percentual anual (VPA). Foram construídos mapas temáticos das taxas bayesianas e a distribuição analisada por Moran local. Resultados: A taxa de detecção passou de 16,2/100 mil habitantes, no primeiro triênio (2010-2012), para 70, no último triênio (2019-2021). A macrorregião Centro-Norte apresentou a maior taxa no último triênio (94,3/100 mil hab.), enquanto a maior tendência de aumento ocorreu na macrorregião Centro-Noroeste, de 2013 a 2018 (VPA = 50,2; IC95% 26,3;78,6). As taxas bayesianas aumentaram na maioria dos municípios. Conclusão: Houve tendência de aumento da sífilis adquirida, principalmente nos dois últimos triênios.

Mapping of QTL associated with rice cooking quality and candidate gene analysis / 生物工程学报

Excavating the quantitative trait locus (QTL) associated with rice cooking quality, analyzing candidate genes, and improving cooking quality-associated traits of rice varieties by genetic breeding can effectively improve the taste of rice. In this study, we used the indica rice HZ, the japonica rice Nekken2 and 120 recombinant inbred lines (RILs) populations constructed from them as experimental materials to measure the gelatinization temperature (GT), gel consistency (GC) and amylose content (AC) of rice at the maturity stage. We combined the high-density genetic map for QTL mapping. A total of 26 QTLs associated with rice cooking quality (1 QTL associated with GT, 13 QTLs associated with GC, and 12 QTLs associated with AC) were detected, among which the highest likelihood of odd (LOD) value reached 30.24. The expression levels of candidate genes in the localization interval were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR), and it was found that the expression levels of six genes were significantly different from that in parents. It was speculated that the high expression of LOC_Os04g20270 and LOC_Os11g40100 may greatly increase the GC of rice, while the high expression of LOC_Os01g04920 and LOC_Os02g17500 and the low expression of LOC_Os03g02650 and LOC_Os05g25840 may reduce the AC. The results lay a molecular foundation for the cultivation of new high-quality rice varieties, and provide important genetic resources for revealing the molecular regulation mechanism of rice cooking quality.

Evidence gaps in orthognathic surgery, a Delphi study protocol

Aim: To assess the research gaps identified in a recent mapping review of orthognathic surgery through their evaluation by clinical experts, leading to a clinically relevant list of research gaps. This will guide future investigations of the topic, focusing on the outcomes of blood loss, infection, and relapse. Methods: The Delphi technique will be used to appraise the identified research gaps. The expert panel will include maxillofacial surgeons who regularly perform orthognathic surgery. Potential participants will be identified through various methods, including contact information from articles in the mapping review, nominations from peers, and social media platforms. Two rounds of surveys will be undertaken with Likert-type and open-ended questions to assess the clinical relevance of research gaps. For the second round, participants will receive a report of the results of the first round. Questions will be modified depending on the answers obtained in the first round. A consensus of 60% will be considered valid. Conclusions: Through this Delphi study, in a collaborative effort between researchers and clinical experts, a comprehensive understanding of the clinical relevance of research gaps in orthognathic surgery will be achieved. The outcomes will guide future investigations, ultimately improving the outcomes and practices in this field.

Mapeamento de competências essenciais de profissionais que atuam na gestão estadual de saúde / Mapping of essential competencies of professionals working in state health management

Resumo: Em função da celeridade de transformações no ambiente externo às organizações, se faz necessário realizar adaptações internas dos processos de trabalho e a adesão das tecnologias contemporaneamente ofertadas. Assim, são requeridas dos gestores novas competências, a serem permanentemente desenvolvidas e aprimoradas. O Sistema Único de Saúde, onde o atendimento e as necessidades dos usuários devem se dar de forma eficiente, eficaz e de qualidade, inclui na descentralização o mecanismo de regionalização, hierarquização e participação, que demanda por gestores em saúde pública com competências e responsabilidades adequadas nos vários níveis de complexidade. Desse modo, para execução deste estudo foi adotado referencial teórico de gestão e mapeamento de competências de Hugo Pena Brandão. Este estudo teve por objetivo realizar o mapeamento das competências gerenciais relacionadas à saúde pública, a partir da perspectiva de profissionais que atuam na gestão em saúde. A metodologia aplicada teve abordagem quantitativa descritiva exploratória. A pesquisa foi realizada em três etapas. Na primeira, a aplicação de questionário, construído a partir do documento Marco Regional para as Américas (MRCESP), documento oficial da Organización Panamericana de La Salud (OPS), traduzido e adaptado ao contexto brasileiro. Este instrumento compõe-se de 56 questões ou competências essenciais divididas em seis domínios e foi respondido por 119 participantes de forma completa, na plataforma de pesquisa Pesquisaonline®. Os respondentes atuavam na gestão das 22 Regionais de Saúde da Secretaria Estadual de Saúde do Estado do Paraná, entre os meses de fevereiro a abril de 2020, e as respostas resultaram no Grau de Expressão da Competência no Trabalho. A análise de dados foi realizada com apoio dos softwares Microsoft Excel® e R®. Na segunda etapa foi realizado o mapeamento das lacunas (gaps) a partir das competências avaliadas pelos participantes. A terceira etapa foi realizada com a apuração do Grau de Prioridade de capacitação. Identificaram-se lacunas nos domínios 2 e 6, e, de acordo com a tabela de Grau de Prioridade de Capacitação, que classifica o Grau de Expressão das Competências no Trabalho, os escores foram de Prioridade Nula ou Muito Baixa. Desse modo, como contribuições, a investigação realizada permite o planejamento de estratégias de capacitação, salientando que os saberes aprendidos estão voltados à prática profissional, como a integração de informações, a transformação de conhecimentos e agir contextualizados, impactando na qualidade da assistência desenvolvida nos serviços de saúde.

Abstract: Due to the speed of transformations in the external environment of organizations, it is necessary to carry out internal adaptations of work processes and the adhesion of technologies currently offered. Thus, new knowledge and skills are required from managers, to be permanently developed and improved. The Unified Health System, where care and the needs of users must be provided efficiently, effectively and with quality, includes in decentralization the mechanism of regionalization, hierarchy and participation, which demands public health managers with adequate skills and responsibilities at various levels of complexity. Thus, to carry out this study, Hugo Pena Brandão's theoretical framework for management and mapping of competencies was adopted 22 Regional Health Departments of the State Health Secretariat of the State of Paraná. The applied methodology had a quantitative descriptive exploratory approach. The research was carried out in three stages. In the first, the application of a questionnaire, built from the document Regional Framework for the Americas (MRCESP), an official document of the Organización Panamericana de La Salud (OPS), translated and adapted to the Brazilian context. This consists of 56 questions or essential competences divided into six domains. The instrument was completed by 119 participants, through the Pesquisaonline® research platform, between February and April 2020, resulting in the Degree of Expression of Competence at Work. Data analysis was performed with the support of Microsoft Excel® and R® software. In the second, the mapping of the gaps was carried out from the competences evaluated by the participants. In the third stage, the Priority Degree of training was determined. Gaps were found in domains 2 and 6, but they were not as expressive, and, according to the table of Degree of Priority of Training, the answers of the participants, who classify the Degree of Expression of Skills at Work, found scores of Null Priority or Very Low. Thus, as contributions, the investigation carried out allows the planning of training strategies, emphasizing that the knowledge learned is focused on professional practice, such as the integration of information, the transformation of knowledge and contextualized actions, impacting the quality of care provided in the services of health.

Resumen: Debido a la velocidad de las transformaciones en el entorno externo de las organizaciones, es necesario realizar adaptaciones internas de los procesos de trabajo y la adhesión de las tecnologías que se ofrecen actualmente. Por lo tanto, se requieren nuevos conocimientos y habilidades de los gerentes, para ser desarrollados y mejorados permanentemente. El Sistema Único de Salud, donde la atención y las necesidades de los usuarios deben ser brindadas de manera eficiente, eficaz y con calidad, incluye en la descentralización el mecanismo de regionalización, jerarquización y participación, lo que demanda gestores de salud pública con competencias y responsabilidades adecuadas en los distintos niveles de complejidad. Así, para la realización de este estudio, se adoptó el referencial teórico de gestión y mapeo de competencias de Hugo Pena Brandão 22 Departamentos Regionales de Salud de la Secretaría de Estado de Salud del Estado de Paraná. La metodología aplicada tuvo un enfoque exploratorio descriptivo cuantitativo. La investigación se llevó a cabo en tres etapas. En el primero, la aplicación de un cuestionario, construido a partir del documento Marco Regional para las Américas, documento oficial de la Organización Panamericana de La Salud (OPS), traducido y adaptado al contexto brasileño. Este consta de 56 preguntas o competencias esenciales divididas en seis dominios. El instrumento fue diligenciado por 119 participantes, a través de la plataforma de investigación Pesquisaonline®, entre febrero y abril de 2020, dando como resultado el Grado de Expresión de la Competencia en el Trabajo. El análisis de datos se realizó con el apoyo del software Microsoft Excel® y R®. En el segundo, se realizó el mapeo de las brechas (gaps) a partir de las competencias evaluadas por los participantes. En la tercera etapa se determinó el Grado de Prioridad de la formación. Se encontraron brechas en los dominios 2 y 6, según la tabla Grado de Prioridad de la Formación, que clasifica el Grado de Expresión de las Habilidades en el Trabajo, los puntajes fueron de Prioridad Nula o Muy Baja. Así, como aportes, la investigación realizada permite planificar estrategias de formación, destacando que los conocimientos aprendidos se focalicen en la práctica profesional, como la integración de la información, la transformación del saber y las acciones contextualizadas, impactando en la calidad de la atención brindada en la servicios de salud.

Hidden blind spot and pseudofixation loss

Background: Correct mapping of the blind spot is important, as it serves as an estimate of fixation reliability. When the blind spot is not seen in the expected location in Humphrey visual field (HVF) printout, the clinician should give a thought to why this might be the case. Purpose: This video describes a series of cases, in which due to different reasons the blind spot could not be seen in the presumed expected location in the grayscale and numeric data of the HVF printout and the possible explanation behind this. Synopsis: When interpreting perimetry results, it is important to know whether the field test is reliable or not. A stimulus presented at the location of physiologic blind spot should not be seen by a patient with a steady fixation in Heijl– Krakau method. Responses will also occur, however, if the patient has a tendency for false?positive responses, or when the blind spot of the properly fixing eye is not in the location where the test stimulus is presented, because of anatomic variation, or if the patient's head is tilted while performing the test. Highlights: Perimetrist should recognize these potential artifact, during the test and relocate the blind spot. In case, such results are seen after finishing the test, it is recommended for the clinician to repeat the test

Food environment near schools in the largest Brazilian metropolis: analyses and contributions based on census data / Ambiente alimentar próximo às escolas na maior metrópole brasileira: análises e contribuições com base em dados censitários / Entorno alimentario cerca de las escuelas en la mayor metrópoli brasileña: análisis y contribuciones a partir de datos censales

Abstract: We aimed to investigate and compare the distribution of establishments that sell food near municipal, state, and private schools in the municipality of São Paulo, Brazil. This cross-sectional, exploratory, and census study was conducted in 3,121 schools. Circular buffers were traced around schools and concentrations or dispersions of food stores (in absolute numbers and densities) were analyzed. A p-trend was calculated to analyze how food stores density behaved as the buffer radius distance increased. Stratified regression models were built to analyze the characteristics of the food environment. Snack bars and street vendors are the most common types of establishments surrounding schools. Some categories of food stores are concentrated (such as candy stores around municipal and private schools, mini markets around municipal schools, and snack bars around private schools), whereas others (such as super and hypermarkets and fruit and vegetable stores) are dispersed around public schools. The food environment around schools shows differences regarding the instance that administers them and private schools have more food stores around them. Poor-quality food environment around schools exposes students to risk factors regarding excessive unhealthy food consumption.

Resumo: Este estudo transversal, exploratório e censitário realizado em 3.121 escolas buscou investigar e comparar a distribuição de estabelecimentos de venda de alimentos no entorno de escolas municipais, estaduais e particulares da cidade de São Paulo, Brasil. Foram traçados buffers circulares ao redor das escolas e analisadas as concentrações ou dispersões de estoques de alimentos (em números absolutos e densidades). Foi calculado o valor de p de tendencia para analisar o comportamento das densidades dos estabelecimentos com o aumento da distância do raio do buffer. As características do ambiente alimentar foram analisadas por modelos de regressão estratificada. Lanchonetes e vendedores ambulantes são os tipos de estabelecimentos mais presentes nos entornos das escolas. Algumas categorias de lojas de alimentos estão concentradas (como lojas de doces em torno de escolas municipais e particulares, minimercados em torno de escolas municipais e lanchonetes em torno de escolas particulares), e outras (como super e hipermercados e hortifrútis) estão dispersas em torno de escolas públicas. O ambiente alimentar ao redor das escolas difere de acordo com a instância que as administra, e as particulares têm mais lojas de alimentos nos arredores. O ambiente alimentar de baixa qualidade ao redor das escolas expõe os alunos a fatores de risco para o consumo excessivo de alimentos não saudáveis.

Resumen: Este estudio transversal, exploratorio y censal realizado en 3.121 escuelas, buscó investigar y comparar la distribución de los establecimientos de venta de alimentos en el entorno de escuelas municipales, estatales y privadas de la ciudad de São Paulo, Brasil. Se trazaron buffers circulares alrededor de las escuelas y se analizaron las concentraciones o dispersiones de las existencias de alimentos (en números absolutos y densidades). Se calculó el valor de p de la tendencia para analizar el comportamiento de las densidades de los establecimientos al aumentar la distancia al radio del buffer. Las características del entorno alimentario se analizaron por medio de modelos de regresión estratificada. Las cafeterías y los vendedores ambulantes son los tipos de establecimientos más presentes en el entorno de las escuelas. Algunas categorías de tiendas de alimentos están concentradas (como tiendas de dulces alrededor de las escuelas municipales y privadas, minimercados alrededor de escuelas municipales y cafeterías alrededor de escuelas privadas), y otras (como super e hipermercados y tiendas de frutas y hortalizas) están dispersas alrededor de las escuelas públicas. El entorno alimentario alrededor de las escuelas difiere según la instancia que las administra, y hay más tiendas de alimentos en las inmediaciones de las escuelas privadas. El entorno alimentario de baja calidad alrededor de las escuelas expone a los estudiantes a factores de riesgo para el consumo excesivo de alimentos poco saludables.

Geographical distribution of nutritional status of adolescents in a Brazilian city in the early years of the pandemic / Distribuição espacial do estado nutricional de adolescentes de um município brasileiro nos anos iniciais da pandemia

ABSTRACT Objective This study aims to build geographic models related to the nutritional status of adolescents and describe territories regarding the prevalence of malnutrition, overweight, and obesity, in order to spatially represent how the nutritional status of adolescents is distributed in the city. Methods Using geocoding techniques, graphic models were built using data from the SISVAN platform, as well as the addresses and nutritional status of adolescents aged 10 to 19 years in the municipality of Divinópolis, in the state of Minas Gerais (Brazil), between 2020 and 2021. Results There was a prevalence of 34% of obesity and overweight in the 2020 and 2021 samples. The graphical models showed that there is no specific pattern of points for the spread of nutritional diagnoses, but it was possible to identify areas of heat and places with a higher concentration of overweight. Underweight had a homogeneous spread and did not stand out in the formation of profiles. Conclusion Geographic tools with the adolescents' nutritional profile were successfully modeled, which have the potential to contribute to better health indicator management in the assessed territory, even with the limitations of the study.

RESUMO Objetivo Este trabalho tem como objetivo construir modelos geográficos relativos ao perfil nutricional de adolescentes e descrever territórios quanto à prevalência de déficit de peso e excesso de peso, de modo a representar espacialmente como o diagnóstico nutricional de adolescentes está distribuído na área estudada. Métodos Através da técnica de geocodificação foram construídos modelos gráficos utilizando a plataforma SISVAN, os endereços e o estado nutricional de adolescentes de 10 a 19 anos do município de Divinópolis, Minas Gerais, nos anos de 2020 e 2021. Resultados Houve prevalência de 34% de excesso de peso na amostra de 2020 e 2021. Os modelos gráficos mostraram que não há um padrão específico de pontos de propagação dos diagnósticos nutricionais, porém foi possível identificar áreas de calor e locais de maior concentração de excesso de peso. O déficit de peso teve um espalhamento homogêneo e não se destacou na formação de perfis. Conclusão Foi possível modelar ferramentas geográficas com o perfil nutricional dos adolescentes, as quais têm potencial de contribuir para a melhor gestão de indicadores de saúde no território avaliado, mesmo com as limitações do estudo.

Cartografia de uma vida que tentou suicídio / Cartography of a life that attempted suicide

Resumo Introdução: O suicídio é um grave problema de saúde pública, ainda permeado de estigmas, fato que dificulta o registro desses eventos e o cuidado às pessoas envolvidas. Por se tratar de um acontecimento multicausal, a construção do cuidado perpassa por ações intersetoriais. Objetivo: Cartografar os elementos envolvidos no contexto de vida de uma mulher que tentou suicídio (usuária-guia), destacando os caminhos percorridos no processo de subjetivação e na produção de cuidado no seu território existencial. Método: Foram realizadas entrevistas semiestruturadas com a própria usuária-guia, amigos, familiares e profissionais de saúde. Esta pesquisa foi realizada no município de Icapuí-CE de agosto/2018 a março/2019. A análise baseou-se em conceitos da Filosofia da Diferença, da teoria de Michel Foucault e da Saúde Coletiva. Resultados: Os caminhos trilhados pela usuária-guia formaram seu território existencial, nesse processo de territorialização, desterritorialização e reterritorialização. Percebeu-se que a rede social foi sua maior proteção, mas também sua maior vulnerabilidade, perpassando por estigmas e identificações. Conclusões: Considerando o despreparo dos profissionais de saúde e da comunidade em lidar com o suicídio, aposta-se em programas permanentes e intersetoriais de prevenção, capacitação e amparo às pessoas envolvidas nesse contexto, além de práticas interprofissionais, principalmente na Atenção Primária à Saúde.

Abstract Background: Suicide is a serious public health problem, still permeated by stigma, a fact that makes it difficult to record these events and care for the people involved. As it is a multicausal event, the construction of care goes through intersectoral actions. Objective: To map the elements involved in the life context of a woman who attempted suicide (guide user), highlighting the paths taken in the subjectivation process and in the production of care in her existential territory. Method: Semi-structured interviews were conducted with the guide user, her friends, family, and health professionals. This research was carried out in the city of Icapuí,Ceará, from August/2018 to March/2019. The analysis was based on concepts of Philosophy of Difference, Michel Foucault's theory, and Collective Health. Results: The paths taken by the guide user formed her existential territory in this process of territorialization, deterritorialization, and reterritorialization. It was noticed that the social network was her greatest protection, but also her greatest vulnerability, crossing stigmas and identifications. Conclusions: Considering the unpreparedness of health professionals and the community in dealing with suicide, we focus on permanent and intersectoral prevention, training and protection programs for people involved in this context, as well as interprofessional practices, especially in Primary Health Care.

As artérias lenticuloestriadas podem interferir na extensão da ressecção tumoral e sobrevida nos gliomas da ínsula? / Can lenticulostriated arteries interfere with the extent of tumor resection and survival in insula gliomas?

Introdução: Os gliomas são tumores encefálicos e da medula espinhal que se originam nas células gliais e cuja progressão invade o tecido cerebral adjacentee e dentre eles um dos mais desafiadores são localizados no lobo cerebral da ínsula. Estas artérias irrigam estruturas nobres e sua lesão pode produzir danos sensitivos, motores e de linguagem. Objetivo: Descrever o impacto da extensão da ressecção, sobrevida global e dos resultados funcionais após a cirurgia dos gliomas insulares, quando estes tumores estejam ou não envolvidos pelas artérias lenticuloestriadas. Métodos: Revisão integrativa nas plataformas virtuais em português e inglês, buscando AND ou OR dados através dos seguintes descritores "Gliomas da ínsula, Mapeamento cerebral, Artérias lenticuloestriadas". A busca inicial foi baseada no título e/ou resumo. Decididos os trabalhos incluíveis foi realizada a leitura na íntegra dos textos. Ao total foram estudados 55 artigos. Resultados: O lobo da ínsula fica "escondido" pela sobreposição dos lobos frontal, parietal e temporal. Para alcançá-lo pode-se realizar as abordagens transsilviana ou transcortical. Ocorre que ao chegar na ínsula visualiza-se significativa ramificação constituída pelas artérias lenticuloestriadas, cuja manipulação pode determinar déficit neurológico e, ao se aprofundar no córtex insular, depara-se com outras estruturas tão importantes quanto a própria ínsula. O conhecimento anatômico das artérias lenticuloestriadas e suas relações é de fundamental importância para a ressecção de glioma insular, pois o comprometimento delas e da artéria cerebral média podem determinar a isquemia dos núcleos da base e da cápsula interna. Conclusão: O tratamento dos gliomas insulares permanece como grande desafio. Devido à sua localização e possibilidade de desenvolvimento de déficits neurológicos na manipulação cirúrgica é necessário não somente conhecer sua localização topográfica, mas também a íntima relação vascular com as artérias lenticuloestriadas. O envolvimento delas pelo tumor possui implicações na sobrevida e na preservação da função neurológica. O conhecimento detalhado da anatomia da região é fundamental para diminuir complicações que afetem grandemente a qualidade de vida dos pacientes.

Introduction: Gliomas are brain and spinal cord tumors that originate in glial cells and whose progression invades the adjacent brain tissue and among them one of the most challenging are located in the cerebral lobe of the insula. These arteries supply noble structures and their damage can cause sensory, motor and language damage. Objective: To describe the impact of the extent of resection, overall survival and functional results after surgery for insular gliomas, when these tumors are or are not involved by lenticulostriate arteries. Methods: Integrative review on virtual platforms in Portuguese and English, searching for AND or OR data using the following descriptors "Insula gliomas, Brain mapping, Lenticulostriate arteries". The initial search was based on the title and/or abstract. Once the included works were decided, the texts were read in full. In total, 55 articles were studied. Results: The insula lobe is "hidden" by the overlap of the frontal, parietal and temporal lobes. To achieve this, transsylvian or transcortical approaches can be performed. It turns out that when arriving at the insula, a significant branch made up of lenticulostriate arteries is seen, the manipulation of which can cause neurological deficits and, when going deeper into the insular cortex, one comes across other structures as important as the insula itself. Anatomical knowledge of the lenticulostriate arteries and their relationships is of fundamental importance for the resection of insular glioma, as their involvement and that of the middle cerebral artery can determine ischemia of the basal ganglia and internal capsule. Conclusion: The treatment of insular gliomas remains a major challenge. Due to its location and the possibility of developing neurological deficits during surgical manipulation, it is necessary not only to know its topographic location, but also the intimate vascular relationship with the lenticulostriate arteries. Their involvement by the tumor has implications for survival and preservation of neurological function. Detailed knowledge of the region's anatomy is essential to reduce complications that greatly affect patients' quality of life.

Geocoding processes in cohort studies: methods applied in the EpiFloripa Aging / Processos de geocodificação em estudos de coorte: métodos aplicados no EpiFloripa Idoso

ABSTRACT OBJECTIVE To describe the process and epidemiological implications of georeferencing in EpiFloripa Aging samples (2009-2019). METHOD The EpiFloripa Aging Cohort Study sought to investigate and monitor the living and health conditions of the older adult population (≥ 60) of Florianópolis in three study waves (2009/2010, 2013/2014, 2017/2019). With an automatic geocoding tool, the residential addresses were spatialized, allowing to investigate the effect of the georeferencing sample losses regarding 19 variables, evaluated in the three waves. The influence of different neighborhood definitions (census tracts, Euclidean buffers, and buffers across the street network) was examined in the results of seven variables: area, income, residential density, mixed land use, connectivity, health unit count, and public open space count. Pearson's correlation coefficients were calculated to evaluate the differences between neighborhood definitions according to three variables: contextual income, residential density, and land use diversity. RESULT The losses imposed by geocoding (6%, n = 240) caused no statistically significant difference between the total sample and the geocoded sample. The analysis of the study variables suggests that the geocoding process may have included a higher proportion of participants with better income, education, and living conditions. The correlation coefficients showed little correspondence between measures calculated by the three neighborhood definitions (r = 0.37-0.54). The statistical difference between the variables calculated by buffers and census tracts highlights limitations in their use in the description of geospatial attributes. CONCLUSION Despite the challenges related to geocoding, such as inconsistencies in addresses, adequate correction and verification mechanisms provided a high rate of assignment of geographic coordinates, the findings suggest that adopting buffers, favored by geocoding, represents a potential for spatial epidemiological analyses by improving the representation of environmental attributes and the understanding of health outcomes.

RESUMO OBJETIVO Descrever o processo e as implicações epidemiológicas do georreferenciamento nas amostras do EpiFloripa Idoso (2009-2019). MÉTODO O estudo de coorte EpiFloripa Idoso buscou investigar e acompanhar as condições de vida e saúde da população idosa (≥ 60) de Florianópolis em três ondas de estudo (2009/2010, 2013/2014, 2017/2019). Com uma ferramenta de geocodificação automática, os endereços residenciais foram espacializados, permitindo a investigação do efeito das perdas amostrais do georreferenciamento em relação a 19 variáveis, avaliadas nas três ondas. A influência de diferentes definições de vizinhança (setores censitários, buffers euclidianos e buffers pela rede de ruas) foi examinada nos resultados de sete variáveis: área, renda, densidade residencial, uso misto do solo, conectividade, contagem de unidades de saúde, e contagem de espaços livres públicos. Coeficientes de correlação de Pearson foram calculados para avaliar as diferenças entre as definições de vizinhança de acordo com três variáveis: renda contextual, densidade residencial e diversidade de uso do solo. RESULTADO As perdas impostas pela geocodificação (6%, n = 240) não ocasionaram diferença estatística significativa entre a amostra total e a georreferenciada. A análise das variáveis do estudo sugere que o processo de geocodificação pode ter incluído uma maior proporção de participantes com melhor nível de renda, escolaridade e condições de vida. Os coeficientes de correlação evidenciaram pouca correspondência entre medidas calculadas pelas três definições de vizinhança (r = 0,37-0,54). A diferença estatística entre as variáveis calculadas por buffers e setores censitários ressalta limitações no uso destes na descrição dos atributos geoespaciais. CONCLUSÃO Apesar dos desafios relacionados à geocodificação, como inconsistências nos endereços, adequados mecanismos de correção e verificação propiciaram elevada taxa de atribuição de coordenadas geográficas. Os achados sugerem que a adoção de buffers, favorecida pela geocodificação, representa uma potencialidade para análises epidemiológicas espaciais ao aprimorar a representação dos atributos do ambiente e a compreensão dos desfechos de saúde.

Practical aspects of functional mri in clinical examinations / Aspectos práticos de rm funcional em exames clínicos / Aspectos prácticos de la rm funcional en los exámenes clínicos

The eloquent cerebral cortices are involved in movement, sensation, speech, vision, and higher cortical functions. Functional magnetic resonance imaging (fMRI) allows the evaluation of brain function, aiding in neurosurgical planning by mapping eloquent cortical areas. Considering the high cost of the hardware involved, the purpose of this work is to present a more affordable, in-house alternative for these studies that can provide adequate results in a clinical setting. We also present some practical information on how to perform these exams. We describe an affordable in-house hardware solution used by an imaging center, and examples of fMRI paradigms used to evaluate motor and language tasks. The fMRI studies show robust activations in eloquent areas consistent with the tasks performed on the exam. Images of post-processed studies illustrate clinical cases. The fMRI have well-established applications, mapping eloquent cortical areas in patients with brain lesions. In the case of surgical planning, it allows the surgeon to maximize the resection area while minimizing sequelae. More affordable hardware can reduce the cost of these exams, making them more accessible to the general public.

O córtex cerebral eloquente está envolvido nas atividades motora, sensação, fala, visão e funções corticais superiores. A ressonância magnética funcional (RMf) permite a avaliação da função cerebral, ajudando no planejamento neurocirúrgico através do mapeamento de áreas corticais eloquentes. Considerando o elevado custo do hardware envolvido, o objetivo deste trabalho é apresentar uma alternativa mais acessível para estes estudos, que possa fornecer resultados adequados em um ambiente clínico. Também apresentamos algumas informações práticas sobre a realização destes exames. Descrevemos uma solução de hardware acessível utilizada por um centro de imagens, e exemplos de paradigmas de RMf usados para avaliar tarefas motoras e relacionadas à fala. Os estudos de RMf mostram ativações em áreas eloquentes, consistentes com as tarefas realizadas no exame com imagens de estudos pós-processados ilustrando casos clínicos. A RMf tem aplicações bem estabelecidas, mapeando áreas corticais eloquentes em pacientes com lesões cerebrais. No caso do planejamento cirúrgico, permite que o cirurgião maximize a área de ressecção enquanto minimiza potenciais sequelas. Equipamentos mais acessíveis podem reduzir o custo destes exames, podendo aumentar a disponibilização ao público em geral.

La corteza cerebral elocuente está implicada en las actividades motoras, la sensibilidad, el habla, la visión y las funciones corticales superiores. La resonancia magnética funcional (RMf) permite la evaluación de la función cerebral, ayudando en la planificación neuroquirúrgica mediante el mapeo de las áreas corticales elocuentes. Teniendo en cuenta el elevado coste del hardware implicado, el objetivo de este artículo es presentar una alternativa más asequible para estos estudios que pueda proporcionar resultados adecuados en un entorno clínico. También presentamos información práctica sobre cómo realizar estos exámenes. Describimos una solución de hardware asequible utilizada por un centro de diagnóstico por imagen, y ejemplos de paradigmas de RMf utilizados para evaluar tareas motoras y relacionadas con el habla. Los estudios de RMf muestran activaciones en áreas elocuentes, coherentes con las tareas realizadas en el examen, con imágenes de estudios postprocesados que ilustran casos clínicos. La RMf tiene aplicaciones bien establecidas en el mapeo de áreas corticales elocuentes en pacientes con lesiones cerebrales. En el caso de la planificación quirúrgica, permite al cirujano maximizar el área de resección minimizando las posibles secuelas. Un equipo más asequible puede reducir el coste de estas exploraciones, aumentando potencialmente su disponibilidad para el público en general.

The development of a digital NGO mapping platform in Tanzania, as a tool to strengthen civil society engagement, in pursuit of Universal Health Coverage

The role of civil society in economic development, improving livelihoods and in providing pathways towards achieving health for all has become increasingly evident. By mapping these organizations, the scope and scale as well as existing capacities, gaps, and opportunities are brought to light. This paper describes the implementation of a digital mapping platform for NGOs; an interactive site which collects, analyses, and visualizes data from a variety of sources about NGOs in Tanzania, through a series of interactive maps, graphs, and charts. We describe the approach and the technology used to develop the platform and its potential contribution towards improving health outcomes. A situation analysis and needs assessment exercise was conducted in February 2023. The developed system requirement specification document served as the guiding document in the design and development of new modules. Participatory techniques and agile iterative methodologies comprising regular stakeholder engagement were employed. A distributed revision control system was used to keep track of system revisions. The modules were deployed to the production server at the National Internet Data Center (NIDC) server room, followed by a system commissioning activity in October 2023. The NGO Information System, NGO Digital Mapping tool, NGO Analytic tool, NGO Search tool and NGO Opportunities module were designed, developed, and commissioned to support NGO operations in Tanzania. The platform was launched during the annual NGO Forum in Dodoma, Tanzania, on October 5, 2023. The modules are publicly accessible and are housed within the NGO Information System (NIS) platform. Investment in whole-of-society engagement to build health systems resilience for universal health coverage is crucial. Leveraging the unique positioning of NGOs draws us a step closer to the ambitious goal of achieving health for all. Through this one-stop web application system, information on the near real-time status, existing gaps, and opportunities for collaboration to serve communities is readily available for all stakeholders. Wide dissemination and enhancement of utilization of the platform across all sectors is now needed, for data to truly inform action.

Exploring biological connotation of blood stasis syndrome of rheumatoid arthritis and establishment of improved animal models based on syndrome-symptom mapping / 药学学报

Blood stasis syndrome is one of the core clinical syndrome of rheumatoid arthritis (RA), but the biological connotation of this syndrome is not clear, and there is a lack of disease improved animal models that match the characteristics of this disease and syndrome. The aim of this study was to screen the candidate biomarker gene set of blood stasis syndrome of RA, reveal the biological connotation of this syndrome, and explore and evaluate the preparation method of the improved animal model based on the characteristics of "disease-syndrome-symptom". The study was approved by the ethics committee of Guang'anmen Hospital, Chinese Academy of Traditional Chinese Medicine (No. 2019-073-KY-01) and the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine (No. TYLL2021[K]018), and the study subjects gave their informed consent. Animal welfare and experimental procedures followed the regulations of the Experimental Animal Ethics Committee of the Chinese Academy of Traditional Chinese Medicine (No. IBTCMCACMS21-2207-01). The whole blood samples were collected clinically from RA patients with blood stasis syndrome (3 cases) or other syndromes (7 types, 3 cases/type), and healthy volunteers (4 cases), and then transcriptome sequencing, KEGG, gene set enrichment analysis (GSEA) and weighted correlation network analysis (WGCNA) analysis were performed. 126 pivotal genes were screened, and their functional annotation results were significantly enriched in "immune-inflammation" related pathways and lipid metabolism regulation (sphingolipids, ether lipid metabolism and steroid biosynthesis). Syndrome-symptom mapping of hub gene set to the TCM primary and secondary symptoms, Western phenotypic symptoms and pathological links showed that joint tingling, abnormal joint morphology, petechiae and abnormal blood circulation are representative of blood stasis syndrome of RA. The results of the improved animal model showed that the rats in the collagen-induced arthritis + adrenaline hydrochloride (CIA+Adr) 3 model group had increased blood rheology, coagulation, platelet function and endothelial function abnormalities compared with the CIA-alone model group, suggesting that the rats with blood stasis syndrome of RA may be in a state of "blood stasis". The results of the study can help to advance the objective study of the evidence of blood stasis syndrome in RA, and provide new ideas for the establishment of an animal model that reflects the clinical characteristics of the disease and syndrome.

Application of Optical Genome Mapping Technology in Detecting Complex Chromosomal Rearrangement / 中山大学学报(医学科学版)

ObjectiveTo investigate the application of optical genome mapping （OGM） technology in detecting complex chromosomal rearrangement. MethodsWe recruited five patients who were diagnosed as complex chromosomal rearrangement at the Reproductive Medicine Center of the Sixth Affiliated Hospital of Sun Yat-sen University from January 2022 to June 2023. They underwent OGM， nanopore sequencing and pre-implantation genetic testing （PGT）. The results were compared with the results of karyotype and chromosomal microarray analysis （CMA）/ copy number variation sequencing （CNV-Seq）. ResultsOGM could detect translocation， invert inversion， and triplet translocation， which were consistent with the results of OGM and CMA/ CNV-Seq. But OGM could not detect Robertsonian translocation. ConclusionBecause of its ultra-long reads， OGM realizes the detection across repetitive regions， and it has great advantages when applied in patients with complex chromosome rearrangement or uncertain karyotype analysis. It can accurately locate breakpoints.

A Bibliometric Analysis of Resin-Bonded Bridge: Performance Analysis and Science Mapping

@#The objective of this study was to identify and characterise various resin-bonded bridge (RBB) articles published in dental journals using bibliometric analysis. The search was performed using the Scopus database to generate publications related to RBB. Data analysis and visualisation were done using Microsoft Excel, Biblioshiny software or VOSviewer. The trend of publication shows an annual growth rate of 7.19 percent within the years 1973–2022. Sixteen articles were cited more than 100 times, with seven highly cited articles focusing on the survival and/or complications of RBB. Matthias,Kern is the most prolific author in RBB research with Journal of Prosthetic Dentistry being the most influential journal. “survival”, “dental bonding” and “zirconia” were identified as core research areas for RBB for the past 10 years. Future research on the incorporation of new technology in prosthesis fabrication to assess the survival and longevity of RBB is expected to increase, with an emphasis on bonding to new materials. This paper presents an overview of scientific production, prominent researchers and countries, emerging keywords and core research areas in RBB research.

Mapping the Constitution in Chinese Medicine Questionnaire to SF-6Dv1 / 中医杂志

ObjectiveTo construct and evaluate the transformation model of the Constitution in Chinese Medicine Questionnaire （CCMQ） to SF-6Dv1 health utility and broaden the applications of CCMQ. MethodsThe data of CCMQ and SF-6Dv1 were collected from 595 participants at baseline， 3 months and 6 months after the comprehensive intervention suitable for the corresponding traditional Chinese medicine （TCM） constitution. The estimation and validation datasets were constructed， and four statistical algorithms including the ordinary least squares （OLS）， MM robust regression （MM）， censored least absolute deviations （CLAD） and the Tobit model were used to create alternative models. The mean absolute error （MAE）， root mean square error （RMSE） and intraclass correlation coefficient （ICC） were used to evaluate the prediction performance of the model. ResultsThe constitution scores of all TCM constitutions by CCMQ was significantly correlated with the SF-6Dv1 health utility value measured at three timepoints； the health utility value of the SF-6Dv1 was positively correlated with gentleness type （r=0.596， r=0.578， r=0.606， all P＜0.05） and negatively correlated with eight unbalanced constitutions （r=-0.586~-0.301， all P＜0.05）. The MM established based on the subscale scores of CCMQ was the optimal mapping model， and the MAE， RMSE， and ICC values were 0.0741， 0.0930 and 0.766， respectively. Gentleness type， qi-deficiency type， phlegm-wetness type， qi-constraint type， and age were the primary factors included in the model. The measured and predicted value of SF-6Dv1 had a moderate positive correlation （r=0.673， r=0.617， P＜0.05） and a good consistency as shown by the Bland-Altman plot. ConclusionBy using MM， the CCMQ can be transformed into SF-6Dv1 health utility value for health economics analysis.

Research Progress on the Application of Intervention Mapping in Tertiary Prevention of Cancer / 中国医学科学院学报

Intervention mapping (IM) is a framework for formulating theory-and evidence-based health education projects with participatory approaches from ecological perspectives.The intervention program designed via IM plays a role in reducing the exposure of cancer risk factors,increasing cancer prevention behaviors,and promoting early cancer screening and rehabilitation of cancer patients.This study summarizes the characteristics,implementation steps,and application status of IM in tertiary prevention of cancer,aiming to provide reference for the application of IM in the health education projects for cancer in China.