A Case of Optic Nerve Infiltration of Acute Lymphocytic Leukemia

Leukemia is a common malignancy in childhood and has various associated ocular manifestations. Clinically, retina is the most commonly involved site and papilledema may be observed due to either direct infiltration or CNS involvement of leukemia. We have experienced a case of mass-like leukemic infiltration in retina and optic nerve in a 16-year-old ALL patient who presented with sudden reduction of visual acuity. With systemic chemotherapy, intrathecal methotrexate and radiotherapy, visual acuity and fundus findings improved. We report this unusual condition with a review of previous report.