RESUMO
The purpose of this paper was to introduce the McNemar΄s χ2 test and SAS and R software implementation of four-fold table data collected from the matched pairs design. Firstly， it was proposed that there were three situations for the data of four-fold table of the paired design， namely ①the data of paired design four-fold table with the special "gold standard" was worthy of statistical analysis； ②the data of four-fold table of the paired design without the special "gold standard" was not worthy of statistical analysis； ③the data of four-fold table collected from the matched pairs design with implicit "gold standard" was worthy of statistical analysis. Secondly， taking the "problems and data" in the first case as the object of statistical analysis， SAS and R software were used to analyze the differences， the calculation results were given and explained， and the statistical and professional conclusions were also made.