1.
Braz. J. Pharm. Sci. (Online)
;
53(1): e16102, 2017. tab, graf
Artigo
em Inglês
| LILACS, SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-839466
RESUMO
ABSTRACT Membrane/lipid rafts (MLRs) are plasmalemmal microdomains that are essential for neuronal signaling and synaptic development/stabilization. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (statins) can disable the N-methyl-D-aspartate (NMDA) receptor through disruption of MLRs and, in turn, decrease NMDA-mediated anxiety. This hypothesis will contribute to understanding the critical roles of simvastatin in treating anxiety via the NMDA receptor.