A Case of Membranous Lipodystrophy Observed in Lichen Amyloidosis

Membranous lipodystrophy is characterized by the presence of microcysts lined by amorphous, eosinophilic material with an arabesque appearance. We experienced a case of a 72-year-old man who had dark brownish, pruritic papules on the arms, legs, and back. Histopathologic examination of a biopsied lesion showed homogeneous, eosinophilic material in the papillary dermis, as well as membranous lipodystrophy. We report a case of membranous lipodystrophy observed in lichen amyloidosis.

An Unusual Case with Membranous Lipodystrophy in a Hypertensive Patient with Transepidermal Elimination

Membranous lipodystrophy represents a peculiar type of fat necrosis that is present in patients with various types of skin disease. It is characterized by the presence of microcysts and macrocysts and is lined by amorphous eosinophilic material with a crenelated arabesque appearance. These findings have been associated with lupus erythematosus, diabetes mellitus, erythema nodosum, trauma, etc. We report a case of a 43-year-old woman who had a red to purple asymptomatic indurated plaque, approximately seven cm in diameter and on the left arm. She was a chronic hepatitis B antigen carrier and had hypertension for four years. Histopathology of the biopsied lesion showed transepidermal elimination of altered collagen and elastic fibers, as well as membranous lipodystrophy changes. There were hypertensive vascular changes including lymphohistiocytic infiltration around the vascular wall, swelling of endothelial cells, increased thickness of the vascular walls, and narrowing of the lumen. We report a case showing transepidermal elimination with membranous lipodystrophy. We carefully suggest that the secondary phenomenon of transepidermal elimination was associated with membranous lipodystrophy and degenerate connective tissues.

A Case of Membranous Lipodystrophy with Stasis Dermatitis / 대한피부과학회지

Membranous lipodystrophy is a peculiar type of fat necrosis, present in patients with various types of skin disease. It is characterized by the presence of microcysts and macrocysts lined by amorphous eosinophilic material with a crenelated arabesque appearance. The eosinophilic lining and microgranules stain positively with periodic acid Schiff, are resistant to diastase. Membranous lipodystrophy can classify into primary idiopathic and secondary types. One of the most common cause of the latter is arterial or venous insufficiency. Stasis dermatitis is a consequence of impaired venous drainage of the legs. The microvascular ischemia is inconsistent and appears to be the main factor of stasis dermatitis and venous ulceration. We report a case of subcutaneous membranous lipodystrophy in a patient with stasis dermatitis.

Three Cases of Secondary Membranous Lipodystrophy / 대한피부과학회지

Membranous lipodystrophy is a peculiar type of fat necrosis, present in patients with various types of skin diseases. It is charaeterized by the presence of microcysts and macrocysts lined by amorphous eosinophilic material with a crenelated arabesque appearance and microgranules in the subcutis with massive fat necrosis. The eosinophilic lining and microgranules stain positively with periodic acid-Schiff, are resistant to diastase, and also stain with Sudan black B. We report three cases of subcutanous membranous lipodystrophy in patients with erythema induratum, posttraumatic panniculitis and morphea with typical clinical and histopathologic findings.