Role and Mechanism of Regulation of MACC1 Expression in Development and Progression of Tumor / 胃肠病学

Metastasis-associated in coIon cancer 1(MACC1)is a recentIy discovered gene which is cIoseIy associated with coIorectaI cancer metastasis,and aIso pIay an important roIe in metastasis of other tumors. Some ceII signaIing pathways or bioIogicaI moIecuIes may be invoIved in the reguIation of MACC1 expression and reIevant mechanism of MACC1 promoting tumor invasion and metastasis. However,the reguIation mechanism and pathways of MACC1 expression are currentIy not compIeteIy known. This articIe reviewed the roIe and mechanism of reguIation of MACC1 expression in the deveIopment and progression of tumor.