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1.
Artigo | IMSEAR | ID: sea-221842

RESUMO

Introduction: Thoracocentesis and pleural biopsy are recommended for the evaluation of undiagnosed exudative pleural effusion. There are multiple etiologies associated with them, out of which malignancy is one of them. Hence, the diagnosis of malignant pleural effusion (MPE) has been proposed in recent perspectives. We aimed to find the profile of MPE, efficacy of percutaneous closed needle pleural biopsy (PCNPB) in diagnosing MPE, overall yield, and complication rate to evaluate the continued relevance of this traditional procedure. Methods: This was a prospective study carried out on consecutive consenting patients at the Department of Pulmonary Medicine at a tertiary care hospital from July 2016 to May 2018. The diagnosis was based on cytobiochemical, microbiological, and histopathological results along with clinical history. Data were analyzed with respect to pleural fluid assessment in terms of cytobiochemical and microbiological evaluation; while pleural biopsy was studied histopathologically. Results: Two hundred and fifty patients with exudative pleural effusion were enrolled. Tuberculosis (218, 87.2%) was the most common etiology followed by malignancy (22, 8.8%). The most common presenting complaint was chest pain (100%) followed by dyspnea (90.47%). Metastatic adenocarcinoma was found in 81.81% followed by mesothelioma in 18.18%. The sensitivity of pleural biopsy for malignancy was found to be 63.63% (p < 0.003, odds ratio [OR]: 2.01), and those fulfilling Leung's criteria, sensitivity was found to be 90.90% (p < 0.001, OR: 3.67). The sensitivity of pleural fluid for malignancy was 18.18% (p < 0.05, OR: 1.51). All cases of mesothelioma have asbestos exposure. The complication in the form of mild post-pleural biopsy pain was encountered in 10%, which required mild analgesics. Other complications in the form of self-resolving pneumothorax were seen in 6%, which increased hospital stay to 2�days and self-resolving hematoma (3%). Conclusion: In this modern era, PCNPB still holds high sensitivity, efficacy rate, and relevance for diagnosing MPE with less complication rate, less hospital stay, and can be done on a daycare basis. Also, we have very less research and paperwork regarding this topic.

2.
Korean Journal of Dermatology ; : 206-209, 2016.
Artigo em Inglês | WPRIM | ID: wpr-182976

RESUMO

Primary ductal adenocarcinoma of the lacrimal gland (PDALG) is a rare tumor accounting for less than 2% of all tumors arising within the orbit. It is classified as a high-grade malignant epithelial tumor due to its variable biologic behavior and aggressive clinical course. Due to its rare incidence, the clinicopathologic profile is poorly identified and generally dependent on the few available reports and case series. Metastatic lesion of PDALG presenting as a skin lesion is very rare with only one previously reported case. We report here a case of metastatic PDALG that presented with cutaneous features. This case illustrates that such a rare malignant tumor may present to dermatologists, requiring prompt diagnosis and management with a multidisciplinary approach.


Assuntos
Adenocarcinoma , Carcinoma , Diagnóstico , Incidência , Aparelho Lacrimal , Órbita , Pele
3.
J. bras. med ; 101(6)nov.-dez. 2013. ilus
Artigo em Português | LILACS | ID: lil-712204

RESUMO

As dificuldades diagnósticas entre mesotelioma pleural e adenocarcinoma metastático na pleura exigem estudo amplo. Os autores ilustram um caso clínico cujo diagnóstico só foi estabelecido após realização de toracotomia, com retirada de material para análise imuno-histoquímica. A diferenciação diagnóstica é de fundamental importância, uma vez que envolvem conduta terapêutica e prognóstico distintos. O estudo adequado deve utilizar material obtido através de toracoscopia ou toracotomia e empregar coloração imuno-histoquímica, estudos com anticorpos monoclonais, microscopia eletrônica e pesquisa de marcadores tumorais.


The diagnosis difficulties distinguishing mesothelioma from pleural metastatic adenocarcinoma request wide study. The authors illustrate a clinical case whose diagnosis was only established after thoracotomy removing material for immune-histochemical analysis. The diagnosis differentiating is very important, because involves distinct treatment and prognosis. The appropriate study should use material obtained through thoracoscopy or thoracotomy and submitted to immune-histochemical coloration, studies with monoclonal antibodies, electronic microscopy and research of tumor makers.


Assuntos
Humanos , Neoplasias Pleurais/diagnóstico , Mesotelioma/diagnóstico , Imuno-Histoquímica , Toracotomia/instrumentação , Microscopia Eletrônica/instrumentação , Anticorpos Monoclonais/imunologia
4.
Med. leg. Costa Rica ; 28(2): 35-42, set. 2011. graf, tab
Artigo em Espanhol | LILACS | ID: lil-637495

RESUMO

Ante el reto diagnostico que presenta una neoplasia hepática que no es bien diferenciada, es este estudio se propone la utilización de un perfil de inmunohistoquímica que incluye citoqueratina (CK) 7, 19 y 20, as¡ como factor de transcripción tiroideo (TTF-1) para demostrar su eficacia en el diagnóstico diferencial de hepatocarcinomas, colangiocarcinomas y metástasis de adenocarcinoma y de ese modo facilitar los diagnóstico en la práctica diaria...


Assuntos
Humanos , Adenocarcinoma , Carcinoma Hepatocelular , Imuno-Histoquímica , Queratinas , Hepatopatias , Costa Rica
5.
Indian J Pathol Microbiol ; 2011 Jul-Sept 54(3): 460-463
Artigo em Inglês | IMSEAR | ID: sea-142025

RESUMO

Background: The cytological diagnoses of serous effusions are usually made by routine cytomorphology with certainty. However, overlapping cases sometimes exist between reactive mesothelial and adenocarcinoma cells. We tried to evaluate the diagnostic utility of HBME-1 in distinguishing between reactive mesothelial cells and adenocarcinoma in serous effusions. Materials and Methods: Fifty-two cytologic specimens processed by cell-block technique were retrieved from the archive and were assigned to two groups: Group I: 26 effusions containing reactive/benign mesothelial cells; Group II: 26 effusions containing carcinoma cells. Immunostaining with HBME-1 was performed using an Envision technique. The staining intensity of cells, according to proportion of immunoreactive cells, was scored as: 0 (negative), 1+ (<10%), 2+ (10-50%), and 3+ (≥50%); and the predominant staining pattern of positive cells were determined. Statistical analysis and tests of significance were performed using SPSS software. Results: The calculated mean values (in percentile) for stained cells in adenocarcinoma and reactive mesothelial cells were 25.57 and 67.88, respectively ( P = 0.001). Thin membranous, thick membranous, thick and thin membranous, cytoplasmic and combined patterns of staining in adenocarcinoma cells were respectively 4 cases (21.1%), 0 case, 0 case, 8 cases (42.1%), and 7 cases (36.8%), and in reactive mesothelial cells, these were 7 cases (26.9%), 1 case (3.8%), 18 cases (69.2%), 0 case, and 0 case, respectively. The intensity of staining in majority (88.5%) of reactive mesothelial cells was scored 3+, but the distribution varied in the other group. Conclusions: The staining pattern and intensity for HBME-1 is a useful panel for differentiation of adenocarcinoma and mesothelial cells.

6.
Annals of Dermatology ; : 472-477, 2010.
Artigo em Inglês | WPRIM | ID: wpr-189833

RESUMO

Primary cutaneous mucinous carcinoma is a rare malignant tumor that originates from the deepest portion of the eccrine sweat duct. Common sites of involvement are the face and scalp. Biopsy shows dermal epithelial cell islands embedded in mucin pools separated by fibrous septae. It is difficult to differentiate this tumor histologically from metastatic adenocarcinoma. Recurrence after excision is common but metastases are rare. We report a primary cutaneous mucinous carcinoma with neuroendocrine differentiation on the right cheek of a 63-year-old man.


Assuntos
Humanos , Pessoa de Meia-Idade , Adenocarcinoma , Adenocarcinoma Mucinoso , Biópsia , Bochecha , Células Epiteliais , Ilhas , Mucinas , Metástase Neoplásica , Recidiva , Couro Cabeludo , Suor
7.
Korean Journal of Obstetrics and Gynecology ; : 1053-1057, 2008.
Artigo em Coreano | WPRIM | ID: wpr-111964

RESUMO

Metastasis to the uterus from extrapelvic malignancy is rare. We experienced a patient who underwent a total gastrectomy and adjuvant chemotherapy due to gastric cancer and subsequently suffered from recurrence at the site of the uterine myoma. This is the first known case report of metastatic adenocarcinoma at uterine myoma from gastric cancer in Korea. We report this case with a brief review of literature.


Assuntos
Humanos , Adenocarcinoma , Quimioterapia Adjuvante , Gastrectomia , Coreia (Geográfico) , Mioma , Recidiva , Neoplasias Gástricas , Útero
8.
Korean Journal of Gastrointestinal Endoscopy ; : 274-277, 2007.
Artigo em Coreano | WPRIM | ID: wpr-82680

RESUMO

Adenocarcinoma of the appendix is a rare neoplasm. Metastatic adenocarcinoma of the appendix from stomach adenocarcinoma is also a very rare finding. A 72-year-old man complained of right lower quadrant abdominal pain for 10 days, and he was diagnosed with acute appendicitis. Appendectomy was performed by a general surgeon. Adenocarcinoma was found on the postoperative biopsy. Subsequently, gastric adenocarcinoma was diagnosed on the gastroscopy with biopsy, and this was proven to be the original site of the appendiceal adenocarcinoma.


Assuntos
Idoso , Humanos , Dor Abdominal , Adenocarcinoma , Apendicectomia , Apendicite , Apêndice , Biópsia , Gastroscopia , Estômago
9.
Korean Journal of Pathology ; : 229-235, 2005.
Artigo em Coreano | WPRIM | ID: wpr-202814

RESUMO

Background : Differential diagnoses of intrahepatic adenocarcinomas (IHAC) play an important role in the detecting primary sites and the determining type of treatment and overall prognosis of the patient. However, histopathologic findings alone have limitations of differential diagnoses of IHAC. Methods : To clarify which tumor related proteins (TRP) are useful for differential diagnoses of IHAC, TRP expression were investigated immunohistochemically, using MUC5AC, MUC2, mAb 91.9H, MUC1, and pS2, and by high iron diamine (HID) staining in 61 clinically confirmed IHACs. Results : MUC5AC (9/18, p0.05) displayed the most frequent expression in cholangiocarcinomas, and MUC2 (11/18, p0.05) was expressed more often in pancreatic adenocarcinomas than other IHAC, while MUC2 and 91.9H were not expressed at all in pancreatic adenocarcinomas. The positivity of several TRP did not correlate with tumor differentiation. Conclusions : MUC5AC, MUC2, mAb 91.9H, and HID may be useful in differentiating cholangiocarcinomas from colorectal adenocarcinomas.


Assuntos
Humanos , Adenocarcinoma , Colangiocarcinoma , Diagnóstico , Diagnóstico Diferencial , Ferro , Prognóstico
10.
Korean Journal of Obstetrics and Gynecology ; : 384-387, 2004.
Artigo em Coreano | WPRIM | ID: wpr-140691

RESUMO

The uterus is an unusual site for metastasis from an extrapelvic neoplasm. Metastasis of gastric cancer to the uterus is rare. We experienced a patient who underwent a gastrectomy and chemotherapy due to gastric cancer and who subsequently suffered a solitary metastatic adenocarcinoma of the uterus from the primary gastric cancer. Similar to Krukenberg tumors of the ovary, lymphatic dissemination is regarded as the route of metastasis from the stomach to the uterine. We report this case with a brief review of literature.


Assuntos
Feminino , Humanos , Adenocarcinoma , Tratamento Farmacológico , Gastrectomia , Tumor de Krukenberg , Metástase Neoplásica , Ovário , Estômago , Neoplasias Gástricas , Útero
11.
Korean Journal of Obstetrics and Gynecology ; : 384-387, 2004.
Artigo em Coreano | WPRIM | ID: wpr-140690

RESUMO

The uterus is an unusual site for metastasis from an extrapelvic neoplasm. Metastasis of gastric cancer to the uterus is rare. We experienced a patient who underwent a gastrectomy and chemotherapy due to gastric cancer and who subsequently suffered a solitary metastatic adenocarcinoma of the uterus from the primary gastric cancer. Similar to Krukenberg tumors of the ovary, lymphatic dissemination is regarded as the route of metastasis from the stomach to the uterine. We report this case with a brief review of literature.


Assuntos
Feminino , Humanos , Adenocarcinoma , Tratamento Farmacológico , Gastrectomia , Tumor de Krukenberg , Metástase Neoplásica , Ovário , Estômago , Neoplasias Gástricas , Útero
12.
Korean Journal of Dermatology ; : 1513-1516, 2003.
Artigo em Coreano | WPRIM | ID: wpr-170905

RESUMO

Paraneoplastic acral vascular syndrome(PAVS) designates the various acral ischemic changes in the elderly patients with occult cancer in the absence of usual causative conditions such as connective tissue disease, hemostatic abnormalities, cardiovascular disease, metabolic disease, peripheral neuropathy, trauma, emboli, and drugs. The common clinical presentation in PAVS is as follows; Raynaud phenomenon, digital gangrene, pulp ulceration, splinter hemorrhage, and acrosclerosis. Most common neoplastic origin of PAVS has been known to be adenocarcinoma occurring in the lung, ovary or uterus. Until now, PAVS have been rarely reported in the Korean literature. We herein report a rare case of PAVS associated with metastatic adenocarcinoma of unknown primary origin.


Assuntos
Idoso , Feminino , Humanos , Adenocarcinoma , Anormalidades Cardiovasculares , Doenças do Tecido Conjuntivo , Necrose da Polpa Dentária , Hemorragia , Pulmão , Doenças Metabólicas , Ovário , Doenças do Sistema Nervoso Periférico , Doença de Raynaud , Úlcera , Útero
13.
Journal of the Korean Gastric Cancer Association ; : 26-28, 2002.
Artigo em Coreano | WPRIM | ID: wpr-104736

RESUMO

Carcinomas of the stomach can spread to adjacent structure by local extension or metastasize to lymph nodes, peritoneum and distant organs. However, the incidence of metastatic bladder cancer originated at the stomach is very rare. A fifty-five year-old man admitted complaining of epigastric pain for 2 months. A large ulceroinfiltrative lesion was seen in the low body, which was confirmed poorly differentiated adenocarcinoma by histological examination. Abdomino- pelvic CT scan showed wall thickening at the greater curvature side of gastric body and urinary bladder. Urine cytology was negative. By transurethral resection of bladder, he was diagnosed as metastatic adenocarcinoma of the bladder. We report a case of stomach cancer with metastasis to urinry bladder.


Assuntos
Adenocarcinoma , Incidência , Linfonodos , Metástase Neoplásica , Peritônio , Neoplasias Gástricas , Estômago , Tomografia Computadorizada por Raios X , Neoplasias da Bexiga Urinária , Bexiga Urinária
14.
Korean Journal of Dermatology ; : 941-943, 1999.
Artigo em Coreano | WPRIM | ID: wpr-29815

RESUMO

A 73-year-old male was presented with a walnut-sized erosive plaque on the lower lip and several skin colored nodules on the neck, the left shoulder and the arm. The other case was a 74-year-old male who had been diagnosed as metastatic lung cancer of unknown origin was consulted for several ulcerative nodules on the face and the left lateral neck. Both patients were finally diagnosed as metastatic adenocarcinoma each from the lung and stomach by histopathologic finding and immunohistochemical studies.


Assuntos
Idoso , Humanos , Masculino , Adenocarcinoma , Braço , Lábio , Pulmão , Neoplasias Pulmonares , Pescoço , Ombro , Pele , Estômago , Úlcera
15.
Annals of Dermatology ; : 73-78, 1996.
Artigo em Inglês | WPRIM | ID: wpr-183990

RESUMO

Cutaneous metastasis from visceral malignancies shows diverse manifestations. Very rarely, cutaneous metastasis mimicks benign mesenchymal tumors. We describe a case in which metastasis from gastric adenocarcinoma mimicked fibrohistiocytic tumors. The diagnosis of cutaneous metastasis was confirmed by the presence of atypical cells and signet-ring cells, positive staining for mucin and positive immunohistochemical stainings for keratins, carcinoembryonic antigen(CEA), and lysozyme within the tumor cells infiltrated in the irregular, intertwining bundles of collagen in the reticular dermis.


Assuntos
Adenocarcinoma , Colágeno , Derme , Diagnóstico , Mucinas , Muramidase , Metástase Neoplásica
16.
Journal of the Korean Ophthalmological Society ; : 1283-1286, 1995.
Artigo em Coreano | WPRIM | ID: wpr-108929

RESUMO

Metastatic carcinoma of the eyelid is extremely rare; Oltmans reported the first case in 1930. We experienced a case of metastatic adenocarcinoma of the left lower eyelid in a 51-year-old male patient. The lesion was clinically similar to chalazion. Histopathologic findings of biopsy revealed gastric adenocarcinoma.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Adenocarcinoma , Biópsia , Calázio , Pálpebras
17.
Tuberculosis and Respiratory Diseases ; : 156-164, 1995.
Artigo em Coreano | WPRIM | ID: wpr-122026

RESUMO

BACKGROUND: We had undergone this study to investigate clinical progress of this disease and to decide the role of aggressive diagnostic approaches, the efficacy of treatments and prognoses. METHODS: A retrospective study was done on 113 patients who had been diagnosed to metastatic adenocarcinoma of pleura by pleural fluid cytology (106 cases) or pleural needle biopsy(22 cases), at Presbyterian Medical Center, from Jan. 1990 to Dec. 1994. RESULTS: 1) The patients were composed of 59 males(52.2%) and 54 females(47.8%), and the mean age distribution was 57.4 +/- 12.1 years. 2) The site of origin was lung cancer 46.9%(53/l 13), stomach cancer 20.4%(23/113), breast cancer 11.5%(13/113), and unknown primary site 6.2%(7/113 cases), as a whole. In male, lung cancer was 55.9%(33/59), stomach cancer was 28.8%(17/59), and in female, lung cancer was 37% (20/54), breast cancer was 24.1% (13/54) of cases. 3) The cardinal symptoms were dyspnea(69%), cough(61%), chest pain(50%), weight loss(50%), anorexia(49%), sputum(43%), malaise(30%). 4) The pleural fluid findings were exudative in 94.4%(102/108), serosanguinous or bloody in 36~53%, unilateral involvement in 74.3%(84/l 13) of cases, and lymphocyte predominance (71 +/- 27%) in differential count of WBC. 5) CEA levels in pleural fluid or plasma were over 10ng/ml in 60.6% (40/66), and ADA levels in pleural fluid were under 40U/L in 95% (57/60) of cases. 6) The patients were managed by various methods, but the efficacy of treatment was uncertain. 7) The mean survival time was 12.7 +/- 13.5 weeks. CONCLUSION: It seems to be no effective treatment methods yet and the prognosis was very poor in this disease, so the objectives of diagnostic approaches and treatment methods should be directed to early diagnosis, treatment and prevention of curable disease. And we must make our best endeavors to lengthen the survival time and improve the quality of patients' life.


Assuntos
Feminino , Humanos , Masculino , Adenocarcinoma , Distribuição por Idade , Neoplasias da Mama , Diagnóstico Precoce , Neoplasias Pulmonares , Linfócitos , Agulhas , Plasma , Pleura , Prognóstico , Protestantismo , Estudos Retrospectivos , Neoplasias Gástricas , Taxa de Sobrevida , Tórax
18.
Korean Journal of Cytopathology ; : 41-45, 1994.
Artigo em Coreano | WPRIM | ID: wpr-726481

RESUMO

Most common metastatic tumors of the thyroid gland are squamous cell carcinoma of head and neck region, adenocarcinoma of breast and lung, malignant melanoma, and renal cell carcinoma of kidney in order of frequency. Metastasis from gastrointestinal tract to the thyroid gland rarely occurs. We experienced a case of fine needle aspiraton cytology of metastatic adenocarcinoma of both thyroid glands from the colon. Cytologic smears showed picket-fence like arrangement of nuclei of carcinoma cells and syncytial type of tissue fragments with acinar pattern on necrotic or mucoid background.


Assuntos
Adenocarcinoma , Biópsia por Agulha Fina , Mama , Carcinoma de Células Renais , Carcinoma de Células Escamosas , Colo , Trato Gastrointestinal , Cabeça , Rim , Pulmão , Melanoma , Pescoço , Agulhas , Metástase Neoplásica , Glândula Tireoide
19.
Korean Journal of Urology ; : 382-385, 1993.
Artigo em Coreano | WPRIM | ID: wpr-120471

RESUMO

Carcinoma of the bladder is a worldwide disease with several histological patterns, 0.5 to 2.0% of which are caused by adenocarcinomas. The etiology of adenocarcinoma of the bladder is unknown Adenocarcinoma of the bladder may be classified as primary, urachal or metastatic based on the site or tumor origin. The primary site of metastatic adenocarcinoma include the rectum, stomach, endometrium, breast, prostate and ovary. Metastasis to the bladder from adenocarcinoma is a relatively rare phenomenon occurring in only 0.26% of cases. When urologic symptoms newly developed to the patients who had malignancy of digestive organs, metastatic malignancy of urinary tact should be considered. Herein, we report a case of metastatic bladder tumor from gastric cancer which occurred 15 months after subtotal gastrectomy.


Assuntos
Feminino , Humanos , Adenocarcinoma , Mama , Endométrio , Gastrectomia , Metástase Neoplásica , Ovário , Próstata , Reto , Neoplasias Gástricas , Estômago , Neoplasias da Bexiga Urinária , Bexiga Urinária
20.
Korean Journal of Gastrointestinal Endoscopy ; : 243-248, 1992.
Artigo em Coreano | WPRIM | ID: wpr-153806

RESUMO

Metastatic cancer with unknown origin(MUO) is not a rare disease in general hospitals and cancer therapeutic centers with a overall incidence of 4-10%. Although there is no universally accepted definition of MUO, an adequate definition includes any case with histologically confirmed metaetatie Carcinoma in which no primary site has been identified inspite of a thorough history; careful physical examinations, and screening tests. Tha diagnostic procedures are important because of therapeutic plans and the prognosis are more dependent upon the cancer tissue type rather than any other factors. Metastasis to the stomach is much more rare occasion in clinical situations of cancer metastasis. We experienced a case of poorly differentiated metastatic adenocarcinoma in stomach which showed: multiple doughnut-like submucosal tumors with central ulceration by gastrofiberscopy and could not identified the primary site in spite of a thorough diagnostic studies including immunochemical histology.


Assuntos
Adenocarcinoma , Hospitais Gerais , Incidência , Programas de Rastreamento , Metástase Neoplásica , Exame Físico , Prognóstico , Doenças Raras , Neoplasias Gástricas , Estômago , Úlcera
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