Discussion on safety and related pharmacological mechanism of compound anshen essential oil in relieving sleep disorders / 中国药理学通报

Aim To study the hypnotic effect and safety of compound anshen essential oil. Methods Gas chromatograph-mass spectrometer (GC-MS) was used to analyze the main active components of compound anshen essential oil. The mouse model of insomnia was established by intraperitoneal injection of para-chloro-phenyl alanine ( PC PA ) , combined with pentobarbital sodium sleep experiment and EEG characteristic monitoring in rats to study the hypnotic effect and mechanism. The safety of compound anshen essential oil was evaluated by acute toxicity test, skin irritation/allergy test and 90-day repeated administration toxicity test. The clinical effect and safety were evaluated by using the sleep monitoring technology for micro-motion sensitive mattress. Results Four components, including Atractylone (34.61%), (+) -Limonene (17.80%) , Linalool (11.63%), and Ocimene (11.67%) , were detected as the main active components of compound anshen essential oil. Compound anshen essential oil in-halation administration for seven days could effectively reduce the autonomic activity of insomnia mice, shorten the sleep latency (P <0.05) , improve the sleep duration, increase of neurotransmitters such as 5-hydroxy tryptamine (5-HT) and -γ-aminobutyric acid (GABA) in brain of mice with insomnia, and the medium dose group had better hypnotic effect. There was no death or adverse reaction in the safety evaluation test. The sleep balance index of 10 subjects with difficulty in falling a-sleep significantly increased (P <0.05), sleep latency was significantly shortened (P <0.05) , total sleep duration and sleep efficiency were improved, and no ad¬verse reactions were found after using the compound anshen essential oil for two days. Conclusions The compound anshen essential oil developed by the research team is safe and effective in relieving sleep disorders, which may be closely related to the co-regulation of the levels of neurotransmitters such as 5-HT and GABA by the four main active components.

Total deformation of multiple implant-supported prostheses through three-dimensional finite element analysis / Deformación total de prótesis múltiple implanto-soportadas a través de un análisis tridimensional por elementos finitos

The purpose of this study was to evaluate through finite element analysis (FEA) the total deformation or displacement as a whole system of multiple implant-supported prostheses in the maxillary anterior region with different implant's length, connection, location and restoration material. An edentulous anterior region of a hemi-maxilla model was used in finite element analysis. The simulations were divided in two groups according to treatment plan: 1) two implants were placed in the upper central incisors, simulating an implant-supported fixed prosthesis (acrylic resin and metal-ceramic) of four elements with cantilever of both upper lateral incisors; 2) two implants placed in the upper lateral incisors, simulating a conventional fixed prosthesis of four elements with both upper central incisors as pontic. Models with cantilever prosthesis in acrylic resin showed the highest values of total deformation, which were 17 times higher than those of metal-ceramic in the distal face of the lateral incisors, regardless of the type of implant connection. In conventional prostheses in acrylic resin, external hexagon connections had lower total deformation values compared with morse taper connection. Also, the implant length was found to have no effect on the values of total deformation. In conclusion, total deformation was substantially greater in all models with acrylic resin restorations.

El propósito de este estudio fue evaluar mediante análisis de elementos finitos (FEA) la deformación total o desplazamiento como un sistema completo de prótesis múltiples implanto-soportadas en la región anterior de la maxila con diferentes longitudes, conexiones y posiciones del implantes y variando el material de restauración. Se utlizó un modelo hemi-maxilar de una región anterior desdentada de un modelo para ser analizado por medio de elementos finitos. Las simulaciones fueron divididas en dos grupos de acuerdo con el plan de tratamiento: 1) dos implantes se colocaron en los incisivos centrales superiores, simulando una prótesis fija implanto-soportada (resina acrílica y metal-cerámica) de cuatro elementos con cantilever de ambos incisivos laterales superiores; 2) dos implantes colocados en los incisivos laterales superiores, simulando una prótesis fija convencional de cuatro elementos con los dos incisivos centrales superiores como póntico. Los modelos con prótesis en cantilever en resina acrílica mostraron los mayores valores de deformación total, siendo 17 veces mayor a los de metal-cerámica en la cara distal de los incisivos laterales, independientemente del tipo de conexión del implante. En las prótesis convencionales en resina acrílica, las conexiones hexagonales externas tenían valores deformación total más bajos en comparación con la conexión cono morse. También, se encontró que la longitud del implante no mostró ninguna influencia en los valores de la deformación total. En conclusión, la deformación total fue sustancialmente mayor en todos los modelos con restauraciones de resina acrílica.

Novel method to simulate micro-motion of human body surface via precision linear module / 医疗卫生装备

To design a new method to simulate the micro-motion of human body surface due to respiration and heartbeat, and to provide detection object and calibration signal for the bio-radar technology. Precision lin-ear module was used to transform rotational movement to linear displacement, with AC servo motor to precisely control the module's rotation. Ultimately, ultralow-frequency micro-motion was produced with its displacement being quantitatively controlled. A system simulating the micro-motion of human body surface was newly built. Compared with the old system, the new one produced micro-motion with better constancy, and realized quantitative control of the motion's dis-placement. The method lays technological foundation for simulating the micro-motion of human body surface due to respiration and heartbeat and may promote the development of bio-radar technology towards intensive and compre-hensive levels.