RESUMO
Background: Microalbuminuria has been associated with clinical risk factors for stroke like diabetes, hypertension, aging, history of myocardial infarction, obesity, smoking and left ventricular hypertrophy. The present study is aimed to determine the potential use of microalbuminurea, as a marker of stroke risk and its outcome in non-diabetic population. Methods: The present study was conducted in the department of internal medicine and department of neurology after the institutional ethical clearance and the informed consent from all the subjects. A total of 116 patients admitted with acute ischemic stroke presenting within 24 hours of stroke onset were recruited for the study. The microalbuminurea was assayed by immunoprecipitation. The stroke severity was assessed by NIH Stroke Severity Statistical Software Package. P value less than 0.05 was considered the level of significance. Results: There was graded co-relation between NIHSSS score and urine albumin creatinine ratio with significant P value of <0.001 in group A, but no such co-relation was seen in group B (P value 0.2). This suggests more the elevated urine ACR more the neurodefecit implying its utility as prognostic marker in acute ischemic stroke. Conclusion: Urine albumin excretion had the strongest correlation with the NIHSSS Score of the patient in acute ischemic stroke. Therefore, measurement of microalbuminurea may help to assess those who are at increased risk and to triage those who may need a more aggressive management protocol.
RESUMO
Se diseña trabajo de tipo descriptivo, transversal y correlacional cuyo objetivo es relacionar la Microalbuminuria (MA) en pacientes diabéticos tipo 1 y 2 No hipertensos, como marcador bioquímico precoz de Hipertrofia Ventricular Izquierda (HVI). A lo efectos se incluyeron 197 pacientes de la consulta de diabetes del Hospital Francisco Antonio Risques de Caracas; luego de aplicar criterios de inclusión se seleccionaron 16 Pacientes con DM tipo 1 y 2. En el grupo control se incluyeron 8 sujetos sanos. A los dos grupos se les realizó ecocardiograma MB y determinó por turbidimetría los niveles de albúmina en muestra parcial de orina de 2 horas. Los datos fueron analizados aplicando pruebas estadísticas descriptivas y correlacionales a través del programa SPSS 10.0. La MA resultó positiva en 75% de los pacientes diabéticos seleccionados; 94% de los pacientes diabéticos presento HVI, de estos 80% presentó simultáneamente microalbuminuria. Estos datos permitan inferir una tendencia entre MA e HVI, en razón de p=0.07.
A descriptive, transversal and correlational study was designed to assess the relationship between non hypertensive diabetic type 1 and 2, microalbuminurea (MA) as a indicator for left ventricular hypertrophy (LVI). We include 197 patients from Francisco Antonio Risques Caracas Hospital´s diabetes consult; exclusion criteria were applied, and 16 diabetic (both type 1 and 2) patients were selected. Control group was formed by 8 healthy subjects. Ekg MB and 2 hour urine sample albumine was collected from each group. Descriptive and correlational analysis were performed to the data obtained by the SPSS 10.0 software. The MA resulted positive in 75% of diabetic patients, and 95% presented LVI; 80% resulted both positive for MA and LVI. This data allows to establish a positive correlation between MA and LVI with p=0,07.