Effects of early hyperbaric oxygen treatment combined with mild hypothermia treatment on patients with severe traumatic brain injury / 中华物理医学与康复杂志

Objective To investigate the clinical effects of early hyperbaric oxygen (HBO) treatment combined with mild hypothermia treatment on patients with severe traumatic brain injury (TBI).Methods A total of 45 participants with severe TBI were randomly divided into combination group (15 cases),mild hypothermia group (15 cases) and control group (15 cases).In control group the patients were managed with treatments for reducing the intracranial pressure (ICP) and controlling the hemorrhage and gastric acid,and with administration of neurotrophic treatment and nutritional support.In addition to above mentioned interventions,the patients in mild hypothermia group received mild hypothermia treatment; while those in the combination group received mild hypothermia plus HBO treatment.The scores of Glasgow coma scale (GCS) were measured before and after treatment.The ICP and pressure of oxygen in brain tissue (PbtO2) were recorded during the process of treatment.Results After treatment,the scores of GCS in 3 groups all increased significantly,but the improvement of the GCS scores in combination group was the highest(P ＜0.05).The ICP in combination group were significantly lower than that in mild hypothermia group and control group since the 5th day (P ＜ 0.05).The PbtO2 in combination group were significantly higher than that in mild hypothermia group and control group since the 7th day(P ＜0.01).Conclusions Early HBO treatment combined with mild hypothermia treatment could improve the therapeutic efficiency in patients with severe TBI.

Detection of serum S-100B protein in patients with severe head injury receiving mild hypothermia treatment / 中华神经医学杂志

Objective To evaluate the effect of mild hypothermia for brain protection by detecting the changes in serum S-100B protein in patients with severe head injury and investigate the possible mechanism. Methods With 100 healthy volunteers as the control group, 100 patients with severe head injury (Glascow Coma Score ≤ 8) received treatment with mild hypothermia (n=50) or normothermia (n=50). Serum samples were collected from the patients early (2-6 h) after the injury and at 1, 3, 5, 7, and 10 days after the injury to measure the levels of S-100B protein. Results In healthy subjects, the serum level of S-100B protein was not associated with age or gender. Patients with severe head injury receiving mild hypothermia treatment and normothermia treatment showed significant differences in serum S-100B protein level from the control group (P<0.01). The patinets with mild hypothermia treatment had significantly lower serum S-100B level than those treated with normothermia atl, 3, 5, 7, and l0 days after the injury (P<0.05). Conclusion Serum S-100B protein has high sensitivity and specificity in the diagnosis of severe head injury, and may serve as an effective biochemical indicator. Mild hypothermia may protect the brain tissue of patients with severe head injury.

Investigation of Mild Hypothermia Treatment on Severe Traumatie Brain Injuries / 医学研究杂志

Objective To explore the prognosis of mild hypothermia treatment in cases of severe traumatic brain injuries(sTBI),improve the knowledge of mild hypothermia treatment on brain injuries.Methods Cases were divided into 2 groups:mild hypothermia treatment group and control group.Mild hypothermia was applied to the cases of sTBI in mild hypothermia group.The prognosis was divided into five grades such as good recovery(GR),moderate disability(MD),severe disability(SD),persisted vegetative state(PVS)and death(D).Results In mild hypothermia group,there were 20 GR cases,5 MD,2 SD and 3 D cases,while in control group,there were 14 GR cases,9 MD,4 SD and 3 D cases.Conclusion Mild hypothermia treatment can improve the prognosis of sTBI.