Evaluation of HBV drug-resistance in vitro and the molecular mechanism of resistance to nucleoside analogue therapy / 医学研究生学报

Nucleoside analogues are currently the main drug therapy against HBV infection. However, this type of therapy can cause gene mutations in HBV that result in drug resistance. The types of mutations caused by nucleoside analogues and the molecular mechanism of in vitro drug-resistance were reveiwed.