Effects of perineurial block of sciatic nerve with different concentrations of alcohol on structure and function of the nerve and its innervated muscles in rats / 中华物理医学与康复杂志

Objective To observe the concentration effects of alcohol in perineurial block on the structure and function of sciatic nerve and it's innervated muscles in rats so as to provide the basis for clinical application of chemical neurolysis.Methods One hundred and fifty female Sprague-Dawley rats were used and randomly assigned into a blank group(BG,n =6),a control group(CG,n =36),a 50％ alcohol group(50G,n =36),a 75％ alcohol group(75G,n =36)and a 99.9％ alcohol group(99.9G,n =36).The CG received physiological saline injection,the 50G,75G,99.9G received corresponding concentrations alcohol perineurial block,respectively.Changes of motor function was assessed,electrophysiological and histomorphological observations of sciatic nerve and its innervated muscles were conducted before and at 24 h,72 h,1 week,4 week,12 week after block.Results(① Hypokinesia and decrease of motor conduction velocity(MCV)were observed at 24 h after block,and peaked at 72 h after block; at 1 week after block,the motor function and MCV improved,the improvement persisted to the 12th week (P ＜ 0.05); but at the 12th week,MCV was still slower than that before block(P ＜ 0.01).②There were significant differences with regard to motot function and MCV of sciatic nerve among 99.9G and the other groups at e ery time point after block(P ＜0.05); ③ Reversible dengeneration of sciatic nerve and hind limb muscle,nonreversible necrosis of muscle occurred more seriously with the increase of alcohol concentration,and the cicatrization in 99.9G was more obvious than that in 50G and 75G at the 12th week; ④Structural lesion of sciatic nerve occurred at 24 h after block and peaked at the 72th h,myelinated axonal sprouts appeared at 1 week after block and persisted to the 12th weck.Conclusions ① The effects of 99.9 ％ alcohol perineural block on the structural lesion,motor function and MCV of sciatic nerve and its related muscle were more obvious than those of 50％ and 75％ alcohol; ② The destructive effect of alcohol block would maintain more than 12 week and neural restoration would maintain more than 12 weeks too.

Effect of Ultrashort Wave Therapy on Motor Conduction Velocity and Expression of Vascular Endothelial Growth Factor of Damaged Movement Neurons in Rats with Sciatic Nerve Injury / 中国康复理论与实践

@#Objective To investigate the effect of ultrashort wave therapy on motor conduction velocity (MCV) and expression of vascular endothelial growth factor (VEGF) in rats with sciatic nerve injury.MethodsThe models of peripheral nerve injury were established by forceps clip of sciatic nerve and then a total of 60 SD rats were divided randomly into three groups, including experimental group (n=24), control group (n=24) and sham operation group(n=12). The rats of experimental group were treated by ultrashort wave therapy after operation. The injured sciatic nerve and spinal cord in waist were sampled at the 1st，2nd，4th，6th week respectively after operation and were observed by electrophysiology and immunohistochemistry.ResultsAfter operation，the MCV of sciatic nerve in both experimental group rats and control group rats is zero in 1st week. Since 2nd week，the MCV of sciatic nerve in rats of both two groups began to arise and the MCV of injuried sciatic nerve in rats of experimental group was higher than that in the control group (P<0.05). In injured spinal cord motoneuron，the Integrated Optical Density(IOD) of VEGF in experimental group was higher than that in the control group (P<0.05).ConclusionUltrashort wave therapy could increase the value of MCV of sciatic nerve and the expression of VEGF in spinal cord in rats,and so it could protect the injured peripheral nerve.

A comparative study of motor conduction velocity and F-wave parameters between diabetes mellitus and healthy subjects / 中国糖尿病杂志

0 1). (4)75 2% of all the patients in DM group showed one or more abnormalities in MCV or F wave parameters, and electrophysiological abnormalitis correlated with, or precede to clinical findings in 175 of 190 patients (92 1%). Conclusion MCV and F wave parameters are sensitive measures for detection of DPN. Among these parameters, FwPL, F MIPL from all the four nerves are the most sensitive. To improve diagnostic accuracy, all the MCV and F wave parameters recorded should be considered.

A Study of Motor Conduction Velocity of Radial Nerve: Comparision of Proximal and Distal Segments / 대한정형외과학회잡지

The usage of electromyography is customized in the diagnosis of the neuromuscular disorder and the determination of motor conduction velocity is important in the diagnosis of the peripheral nerve lesion and in the posing of the site and severity of nerve damage. Although the radial nerve is frequently involved in generalized neuropathy and in entrapment syndrome, relatively fewer reports have appeared in the literature regarding the radial nerve. The purpose of this study is to determine the normal data of the motor conduction velocity of the proximal and distal segments of the radial nerve. The radial nerve fibers supplying the extensor indicis muscls muscle was stimulated at Erb's point, above the elbow and in the distal forearm and its muscle action potential was sampled. Seventy-four radial nerve were studied in thirty-seven healthy young subjects. The results obtained were as follows; 1. The mean proximal velocity was 70.7±6.8m/sec and the mean distal velocity was 57.6±4.3m/sec. 2. In any case tested, the proximal velcity was over 55m/sec. 3. The proximal velocity was faster than the distal velocity and the mean difference was 13.1m/sec In only 7 of the 74 nerves tested, the proximal velocity was slower than the distal velocity and the difference of Sm/sec was the most reversal. 4. The velocity in dominant limb was faster than that in nondominant limb. 5. There were no significant difference between the sexes.