Actividad expectorante y toxicológica de una formulación elaborada a partir de Eucalyptus globulus Labill, Borago officinalis L, Y Sambucus Nigra L / Expectorant and toxicological activity of a formulation made from Eucalyptus globulus Labill, Borago officinalis L., and Sambucus Nigra L

Introducción: Eucalyptus globulus Labill., (eucalipto), Borago officinalis L. (Borraja) y Sambucus nigra L. (saúco) son especies vegetales de amplio uso popular por sus propiedades antitusígenas y mucolíticas. Objetivo: evaluar los efectos farmacológico y toxicológico de un fitofármaco elaborado con el extracto de la mezcla de las tres plantas. Métodos: a partir de las hojas secas de cada especie, se elaboraron dos extractos fluidos de las tres plantas: E. globulus B. officinalis y S nigra, mezcladas en proporción 25:25:50, respectivamente, se empleó el método de percolación y como disolventes etanol de concentraciones al 30 y 70 por ciento. Para la evaluación del efecto mucolítico se empleó el modelo de Rojo Fenol en secreciones de ratón y se ensayaron los extractos de concentraciones alcohólicas al 30 y 70 por ciento. El estudio toxicológico se realizó al extracto de concentración alcohólica al 70 por ciento. Resultados: en la evaluación farmacológica se encontró que los extractos hidroalcohólicos al 30 y 70 por ciento presentaron efecto mucolítico, con una efectividad ligeramente superior para el extracto en alcohol al 70 por ciento. Cuando se evaluó toxicológicamente, este extracto no presentó efecto tóxico en el ensayo de toxicidad aguda a dosis límite. Conclusiones: las formulaciones elaboradas con los extractos fluidos de las plantas empleando etanol al 30 y 70 por ciento, mostraron efecto mucolítico en el modelo de rojo fenol en secreciones de ratón y con las condiciones experimentales del estudio. El extracto de las plantas en etanol al 70 por ciento no presentó efecto tóxico en el ensayo de toxicidad aguda a dosis límite(AU)

Introduction: Eucalyptus globulus Labill. (eucalyptus), Borago officinalis L. (borage) and Sambucus nigra L. (elder) are plant species commonly used in folk medicine for their antitussive and mucolytic properties. Objective: Evaluate the pharmacological and toxicological effects of a drug made with an extract obtained from a mixture of the three plants. Methods: Two fluid extracts were obtained from dry leaves of the three species, E. globulus, B. officinalis and S. nigra, mixed in a 25:25:50 proportion. The method used was percolation and the solvents were 30 percent and 70 percent ethanol. The mucolytic effect was evaluated with the phenol red model in mouse secretions, and assays were conducted of the 30 percent and 70 percent alcoholic extracts. Toxicological analysis was performed on the 70 percent alcoholic extract. Results: Pharmacological evaluation found that 30 percent and 70 percent hydroalcoholic extracts display a mucolytic effect, effectiveness being slightly higher in the 70 percent alcoholic extract. When evaluated toxicologically, this extract did not show any toxic effect in the dose-limiting acute toxicity test. Conclusions: The formulations developed with fluid plant extracts using 30 percent and 70 percent ethanol were found to have a mucolytic effect in the red phenol model in mouse secretions under experimental test conditions. The 70 percent ethanolic plant extract did not have a toxic effect in the dose-limiting acute toxicity tes(AU)

Efficacy and safety of domestic inhaled N-acetyl-L-cysteine solution in mucolytic therapy / 中国药学杂志

OBJECTIVE: To evaluate the clinical efficacy and safety of domestic inhaled N-acetyl-L-cysteine (NAC) solution in mucolytic therapy. METHODS: This was a multi-centre, randomized, double blinded and positive parallel trial. Fluimucil, an imported drug with the same active ingredient was used as control. Two hundred and thirty-four patients suffering from acute and chronic lower respiratory tract infection were enrolled, 117 patients in study group and control group respectively. Both groups were treated by respective drug 3 mL given by inhalation, bid, for 5-7 d. Non-inferiority test and two-sided test were used to analyze the statistic difference. RESULTS: The effective rates of the study group were 74.8% (PPS) and 74.1% (FAS). There was no significant difference (P > 0.05) between the two groups. There were no serious adverse events and major adverse events during the study. The incidence of adverse events in study group was 14.5%. There was no significant difference (P > 0.05) between the two groups. According to the preset non-inferior creteria, ie 15%, the non-inferiority of the test drug was established. CONCLUSION: The clinical efficacy and safety of the domestive inhaled N-acetyl-L-cysteine solution in mucolytic therapy are equal to fluimucil.

Antitussives, mucolytic agents and expectorants in clinical practice / 대한내과학회지

Cough is a protective reflex and also a common symptom of many respiratory diseases. The basic principle of management in chronic cough is treatment of its underlying cause. However, certain situations will necessitate cough suppressant therapy on a short-term basis for symptomatic relief of cough. Antitussives, expectorants and mucolytic agents are often used as the cough suppressant. Most of these drugs, however, are not consistently effective in reducing cough in adequately performed clinical trials. The aim of this brief review is to provide the list and some rationale for the currently available antitussive agents to practitioners.

Use of Antitussive, Mucolytic Agents and Expectorants

No abstract available.

The effect of L-methylcysteine HCL on chronic obstructive respiratory diseases

Twenty patients with chronic obstructive bronchopulmonary diseases were put on a clinical trial using oral L-methylcysteine hydrochloride compared to placebo. Fifteen patients improved significantly when given the active drug. Five patients did not improve at all. All patients did not show any response to oral placebo. The patients who were benefited by oral L-methylcysteine demonstrated very convincing reduction in sputum viscosity.(Summary)

Study on the efficacy and safety of N-acetyl-L-cysteine injection in mucolytic treatment of respiratory tract infection administered by inhalation route / 重庆医科大学学报

0.05).Conclusion:NAC injection is an effective and well-tolerated mucolytic agent as administered by inhalation route for patients with thick,viscid sputum.