RESUMO
Viral nanoparticles (VNP) are virus-based nanoparticle carriers that can be used as a building block for novel drug carriers with a variety of properties, such as enhancing their biological compatibility and ncreasing their targeting efficiencies. By the means of chemical modification and genetic engineering, researchers are able to connect various purposes molecules to the surfaces of VNP and adjust/change the protein amino acid sequence and the amino acid residues types of capsid protein, thereby mproving the drug delivering performances of capsid protein. In this paper, we review the recent advances of VNP' applications in drug delivery, and highlight the structure, surface modification methods and drug delivery features of several plant viral nanoparticles.
RESUMO
The occurrence of nanoparticle carriers has greatly changed the traditional remedies of gastric cancer and other malignant tumors which makes the chemotherapeutic drugs possess better distribution, better targeting, less side-effects, and the ability to withstand the drug-resistance of tumor cells. Utilization of nanoparticle carriers in lymph-targeted chemotherapy of gastric cancer can not only achieve a better curative effect,but also direct the operation and improve patients' quality of lives. It has an expansive application foreground.