Establishment of Microbial Limit Test Method for Naoliqing Capsules and Verification of the Methodology / 中国药房

OBJECTIVE:To establish a microbial limit test method for Naoliqing capsules and validate the methodology.METHODS:In accordance with Chinese Pharmacopoeia 2005th edition,a verification test on the microbial limit test mothod of Naoliqing capsules was carried out using escherichia coli,bacillu subtilis,staphy lococcus aureus,aspergillus niger and candida albicans.RESULTS:The recovery rates of the above different test bacteria were all above 70%,and the recovery rates of 5 test bacteria in diluting agent were all above 70%.CONCLUSION:The routine method is applicable for microbial limit test of Naoliqing capsules.

Improvement in Quality Standard of Naoliqing Capsule / 中国药房

OBJECTIVE:To improve the quality standard of Naoliqing capsule. METHODS: The Sus scrofa domestica and Achyranthes bidentata in Naoliqing capsule were identified by TLC, and the content of oleanolic acid was determined by HPLC. RESULTS: The characteristic TLC spots of the Sus scrofa domestica and Achyranthes bidentata in Naoliqing capsule were detected. The linear range of oleanolic acid was 0.5～7.5 ?g(r=0.999 6) with an average recovery of 97.43%(RSD=1.94%,n=6). CONCLUSION: The results are conducive to the improvement of the quality standard of Naoliqing capsule.