Avaliação da prática de automedicação com descongestionantes nasais por estudantes da área da saúde / Evaluation of self-medication practice with nasal decongestants for students in the health field

Objetivo ­ Evidenciar a prática de automedicação e o uso indiscriminado de descongestionantes nasais pelos estudantes da área da saúde. Métodos ­ Para elaboração da pesquisa, foi realizada coleta de dados por meio de aplicação de questionário, com intuito de evidenciar a prática de automedicação e a frequência do uso indiscriminado dos descongestionantes nasais, a pesquisa foi feita entrevistando 100 participantes, sendo 50 homens e 50 mulheres no período de 18 de Novembro de 2015 a 11 de Março de 2016. Resultados ­ Avaliou-se através dos dados obtidos que a prática de automedicação e o uso indiscriminado e irracional desses medicamentos entre os estudantes ocorrem com frequência. Conclusão ­ Através dos dados obtidos foi possível concluir que o uso de descongestionantes nasais entre os alunos de ambos os sexos ocorrem, de maneira indiscriminada, de modo contínuo e dependente, sendo que, o fato da ausência de orientação adequada no momento da dispensação pode contribuir para o uso irracional.

Objective ­ Highlight the widespread use of nasal decongestants for health care students. Methods ­ To prepare the study, data collection was performed by application of questionnaire, in order to Highlight the frequency of the indiscriminate use of nasal decongestants, the research was done by interviewing 100 participants, 50 men and 50 women in period from 18 November 2015 to 11 March 2016. Results ­ Reviewed up through the data that the indiscriminate and irrational use of these drugs among students occur frequently. Conclusion ­ Through the data we found that the use of nasal decongestants among students of both sexes occur indiscriminately, continuous and dependent manner, and the fact of the absence of proper guidance at the time of dispensation can contribute to the irrational use.

Optimization, Development and evaluation of Microemulsion for the release of combination of Guaifenesin and Phenylephrine.

Guaifenesin and Phenylephrine possess greater water solubility but lower permeability and bioavailability. The aim of this study is to develop a microemulsion to overcome these issues. Castor oil, Oleic acid and Emu oil were selected as oil phase. Tween 80 and Span 80 were selected as surfactants.2-propanol and ethanol were selected as co-surfactants. Optimization of co-surfactant was done by taking a series of O/W microemulsions which were formulated by titration method. 32 formulations were formed initially and based on various physical parameters like clarity, Stability, density, viscosity, pH and electrical conductivity, 17 formulations were narrowed down. The particle size study was carried out by zeta analysis and the results proved that the formulations were nano sized. FTIR studies proved that there was not much interaction between the drugs in the formulation. In-vitro dissolution studies were performed for all the 17 formulations individually for both the drugs was found. The optimum formulation where sustained release for both the drugs was found to be in the combination of Oleic acid: Tween 80: Water: 2-propanol (1:3:5:9). This formulation was subjected to ex-vivo diffusion study and the permeation through the membrane was found.

A Prospective Randomized Open Trial of Nasal Irrigation and Nasal Decongestant for Sinusitis in Children / 소아알레르기및호흡기학회지

PURPOSE: The management of sinusitis in children is controversial. Antibiotic is known as the most essential management. Despite nasal irrigation and nasal decongestant have been used as adjunctive treatments of sinusitis, it is still unclear whether these are effective on sinusitis. Therefore, we used antibiotics with either nasal irrigation and an oral nasal decongestant and tried to estimate the outcome of each case. METHODS: This study was conducted with sinusitis patients who visited our pediatric respiratory disease clinic. They were randomized into 4 groups: Group 1 were treated with a high dose of amoxicillin only; Group 2 were treated with nasal irrigation and a high dose of amoxicillin; Group 3 were treated with a nasal decongestant and a high dose of amoxicillin; and Group 4 were treated with nasal irrigation, a oral nasal decongestant, and a high dose of amoxicillin. Responses to treatment were estimated more than 4 days after the beginning of the therapy in acute or subacute sinusitis, and more than 7 days chronic sinusitis. RESULTS: The responses to the treatments the 4 groups were not comparable. A favorable therapy was not found, regardless of whether a patient had suppurative rhinorrhea, nasal stuffness, typical findings of PNS plain radiograph, or adenoid hypertrophy. CONCLUSION: The use of nasal irrigation or a oral nasal decongestant as an additional therapy to antibiotics for the symptoms of pediatric sinusitis showed no additional effects on sinusitis.