Efficacy of nystatin vaginal effervescent tablets and nifuratel tablet combined with recombinant human interferon alpha 2b suppository in the treatment of candida vaginitis / 中国基层医药

Objective To explore the efficacy of nystatin vaginal effervescent tablets , nifuratel tablet combined with recombinant human interferon alpha 2b suppository in the treatment of candida vaginitis .Methods 124 patients with candida vaginitis were selected as the research subjects .The patients were randomly divided into two groups according to different treatment .The control group was treated with nystatin vaginal effervescent tablets +nifuratel tablet,the study group was given recombinant human interferon alpha 2b suppository on the basis of the control group.The symptoms,clinical curative effect,quality of life score,adverse reaction rate were observed and compared in the two groups .Results There were no statistically significant differences between the two groups in symptom and physical signs before treatment (all P>0.05).After treatment,the vulvar itching,burning pain,abnormal leucorrhea,redness symptoms and signs of the study group were (0.95 ±0.44)points,(1.02 ±0.51)points,(1.13 ± 0.62) points,(1.09 ±0.56) points,which were significantly lower than those of the control group [(1.42 ± 0.98)points,(1.28 ±1.02)points,(1.38 ±1.17)points,(1.37 ±1.12)points,t=2.529,2.512,2.505,2.618,all P<0.05].The total effective rate of the study group was 95.2％,which was significantly higher than 74.2％ of the control group (Z=-2.839,P<0.05).After treatment,the quality of life scores of physiological function ,bodily pain,mental health,emotional function and social function in the study group were (80.16 ±9.23)points,(84.22 ± 9.95)points,(87.49 ±10.46) points,(89.27 ±12.35) points,(88.21 ±11.74) points,which were significantly higher than those in the control group[(67.58 ±5.34)points,(71.49 ±7.28)points,(73.52 ±7.61)points,(76.83 ±8.32)points,(75.51 ±8.16) points,t=9.728,8.577,9.036,7.039,7.537,all P<0.05].The incidence rate of adverse reactions of the study group was significantly lower than that of the control group (χ2 =10.978,P<0.05). Conclusion Nystatin vaginal effervescent tablets ,nifuratel tablet combined with recombinant human interferon alpha 2b suppository in the treatment of candida vaginitis can significantly improve clinical symptoms ,improve the therapeutic effect,and improve the quality of life of patients with significant clinical value ,it is worthy of reference .

Influence of different administration regimens for treatment of bacterial vaginosis on vaginal microflora and the expression of immune factors / 天津医药

Objective Tracking of the vaginal microflora recovery and the expression of immune factors from untreated and treated patients with bacterial vaginosis (BV) by using different administration regimens and studying the relationship of treatment results and regimen selections. Methods 25 healthy females were selected as a control group and 100 BV patients were randomly divided into 4 groups (n=25/group). Group A: Intravaginal administration of metronidazole (× 7 d), Group B:Continuous intravaginal administration of metronidazole (× 7 d) and then live Lactobacillus Capsule (× 7 d) , Group C: Intravaginal administration of nifuratel (× 7 d), Group D: Continuous intravaginal administration of nifuratel (× 7 d) and then live Lactobacillus Capsule (×7 d). The microecological assessment system and EILSA were used to compare the clinical efficacy, vaginal microflora recovery and the changes in IL-8, TLR2 and TNF-αof the vaginal lavage fluid in healthy women or patients with bacterial vaginosis before and after treatments by four treatment strategies. Results ① The vaginal microflora imbalance, flora disturbance, pH value increased were presented in BV group compared with the control group.②Compared to the median of IL-8, TLR2 and TNF-α in vaginal lavage fluids of control group, there was no significant difference in IL-8 level but both TLR2 and TNF-αwere significantly increased (P<0.05) in BV group. The immune factors had no significantly difference in all BV groups.③The therapeutic effect in each BV groups was compared after stopping treatment for 7 days. The cure rate and the vaginal microflora recovery rate were significant higher in group B and D than group A and C (P<0.05). ④ After treatment there was no significant change in IL-8 level but there was an obviouslydecrease in TLR2 and TNF-α(P<0.05). The decreased levels are more significant in groups B and D than groups A and C (P<0.05). Conclusion By combining with the microecological assessment system to evaluate the therapeutic effect of BV, our research suggests that the sequence schemes of nifuratel plus live Lactobacillus Capsule is more effective in therapy effect, restoring normal vaginal micro-ecological environment and vaginal local immunity than metronidazole used alone.

Effect of Gynopathic antiphlogistic formula combined with nifuratel and nysfungin on CRP, oxidative stress products and its efficacy in senile colpomycosis / 中国生化药物杂志

Objective To explore the effect of Gynopathic antiphlogistic formula combined with nifuratel and nysfungin on serum levels of CRP, oxidative stress products and its efficacy in the treatment of senile colpomycosis.Methods 66 elderly patients of colpomycosis from October 2014 to December 2015 in department of obstetrics and gynecology of Nanxun Integrative Medicine Hospital were selected and randomly divided into two groups, 33 cases in each group.Patients in control group received nifuratel and nysfungin soft capsule, the experimental group received Gynopathic antiphlogistic formula on the basis of control group, with two courses, 6 days for one course.The serum inflammatory factors, oxidative stress products and clinical curative effect were compared.Results Compared with pre-treatment, the serum TNF α, CRP, IL-6, IL-8 levels decreased (P<0.05), SOD, NO increased (P<0.05), MDA, ET-1 decreased (P<0.05); compared with control group, the serum TNF α, CRP, IL-6, IL-8 level were lower (P<0.05), SOD, NO were higher (P<0.05),and MDA, ET-1 were lower (P<0.05).The clinical efficacy of experimental group was better than that of control group (Z=-2.902,P=0.004).Conclusion The Gynopathic antiphlogistic formula combined with nifuratel and nysfungin has a better efficacy in the treatment of senile colpomycosis, which could effectively reduce the serum levels of inflammatory factors, oxidative stress products with high safety.

Preparation and Quality Control of Nifuratel Vaginal Effervescent Tablets / 中国药房

OBJECTIVE:To prepare nifuratel vaginal effervescent tablets(NVET)and establish a method for its quality control.METHODS:The NVET was prepared using acid or alkali effervescent by principal ingredient-separated granulation.The content of the principal ingredient was determined by UV spectrophotometry.RESULTS:The preparation was white or off-white colored tablet and its property was up to the standard stated in Chinese Pharmacopeia(2005 Edition)in identification and test.The linear concentration range of nifuratel was 100～400 ?g?mL-1(r=0.999 6)with an average recovery rate of 101.1%(RSD=0.62%,n=6).CONCLUSION:The preparation process for NVET is simple,and its quality is stable and controllable.