Papillary Carcinoma: A Rare Cause of Cutaneous Lesion on Dorsum of Nose

The skin of the nose is a common site for various benign and malignant lesions. Herein, we report a cutaneous nodular lesion on the dorsum of the nose in an 80-year-old female, which was surgically excised under local anesthesia. On histopathological examination, she was diagnosed with papillary carcinoma, a very rare disorder at such a location. The patient was followed-up and no recurrence was noted.

Caracterización clinicoquirúrgica y anatomopatológica de pacientes con cáncer de tiroides en el período 1995-2011 / Clinical surgical and pathological characterization of patients with thyroid cancer in the period 1995-2011

Se realizó un estudio observacional, descriptivo, retrospectivo y longitudinal de 84 pacientes con cáncer de tiroides, atendidos en el Servicio de Cirugía General del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, desde enero de 1995 hasta abril de 2011, con vistas a caracterizarles desde los puntos de vista clínico, quirúrgico y anatomopatológico. En la serie predominaron el grupo de 31-45 años, el sexo femenino, el carcinoma papilar como la variedad histológica más frecuente -- con nódulos únicos -- y la disfonía como principal complicación. Se corroboró la eficacia de la ecografía en la detección de lesiones nodulares, así como también existió una elevada correspondencia entre los resultados de la citología aspirativa con aguja fina y el diagnóstico histológico; asimismo, la biopsia por congelación constituyó un procedimiento útil en citologías negativas o dudosas.

An observational, descriptive, retrospective and longitudinal study was carried out in 84 patients with thyroid cancer, attended in the General Surgery Service of "Dr. Juan Bruno Zayas Alfonso" Teaching General Hospital in Santiago de Cuba, from January, 1995 to April, 2011, with the purpose of characterizing them from the clinical surgical and pathological points of view. Age group of 31-45 years, female sex, papillary carcinoma as the most frequent histological variety -- with single nodules -- and dysphonia as a major complication prevailed in the series. The effectiveness of the ultrasound was confirmed by detecting nodular lesions, and there was a high correspondence between the results of the fine needle aspiration biopsy and histological diagnosis; also, frozen biopsy was an useful procedure in negative or doubtful cytologies.

A Case of Dermatofibrosarcoma Protuberans Presenting as an Anetoderma-like Lesion with Nodular Lesions / 대한피부과학회지

Atrophic dermatofibrosarcoma protuberans (DFSP) is an uncommon clinical variant, which clinically mimics other atrophic dermatological conditions. Given the typical 'protuberant' morphology of DFSP, such atrophic lesions may be difficult to diagnose clinically. We report a 44-year-old man who presented with an 8-month history of an asymptomatic, depressed, anetoderma-like plaque on the right subclavicular area. He also presented with a 1-year history of a 1.5x1.5 cm, asymptomatic, firm, erythematous nodule above an atrophic lesion. Biopsy specimens were taken from each lesion. These specimens, along with histochemical staining for CD34, established the diagnosis of dermatofibrosarcoma protuberans.

Tuberculosis hepática pseudotumoral: a propósito de un caso / Nodular form of local hepatic tuberculosis: case report

La tuberculosis hepática focal aislada, en ausencia de afectación activa pulmonar, es una forma rara de presentación de dicha enfermedad. Presentamos un caso de forma pseudotumoral de tuberculosis hepática en un niño de 3años 9 meses de edad, destacando la dificultad diagnóstica de esta entidad, por su semejanza radiológica con el cáncer de hígado primario y metastásico. La punción biopsia dirigida por ecografía o TAC constituye un buen método diagnóstico, alternativo. El examen histológico revela una lesión granulomatosa tuberculoide, con buena respuesta al tratamiento tuberculostático.

In the absence of active pulmonary disease, hepatic focal tuberculosis is rare form of tuberculosis. We present a case of nodular form of local hepatic tuberculosis in a 3 year 9 months child. Diagnosis is difficult because of its radiological similarity with primary or metastatic hepatic cancer. Percutaneus biopsy with US or CT guidance offers a good diagnostic alternative to laparoscopy. Histology examination revealed a tuberculoid granulomatous lesion. The disease has a good response to tuberculostatic treatment.

Expressions of Galectin-3 and HBME-1 in Nodular Lesions of the Thyroid

PURPOSE: Galectin-3 and HBME-1 have been recognized as useful markers for the diagnosis of the thyroid lesions. In this study, we investigated whether they have a diagnostic value for nodular lesions of the thyroid. METHODS: We investigated the galectin-3 and HBME-1 expressions in 14 nodular hyperplasias, 30 papillary carcinomas, 17 follicular adenomas and 8 follicular carcinomas with using immunochemistry. RESULTS: Galectin-3 was positive in 96.7% of the papillary carcinomas and this incidence was significantly higher (P=0.0001) than that of nodular hyperplasia, 7.1%. However, the galectin-3 expressions of follicular adenoma and follicular carcinoma were not significantly different. HBME-1 was positive in 50.0% of the follicular carcinomas and this incidence was significantly higher (P=0.0001) than that of follicular adenoma. CONCLUSION: Galectin-3 and HBME-1 may be useful markers to diagnose papillary carcinoma. Although HBME-1 contributes to differential diagnosis of follicular adenoma and follicular carcinoma, further study is required.

Evaluation of CTHA/CTAP in diagnosis of liver cancer recurrence after interventional therapy / 介入放射学杂志

Objective The application of CTHA/CTAP in examination of liver cancer relapse after interventional therapy were retrospectively analyzed.Methods The CTHA/CTAP and DSA were performed on 19 patients with primary hepatic cancer after receiving TACE procedure followed by obvious rising of AFP.Results CTHA/CTAP discovered 14 recurrent lesions in the peripheral region of the embolized tumors,and 15 new lesions.In comparison,DSA only discovered 6 recurrent lesions and 8 new lesions.Conclusion Comparing with DSA,CTHA/CTAP is a more sensitive and reliable method in detection of liver cancer relapse after interventional therapy.

A Case of Congenital Cytomegalovirus Encephalopathy with Patchy, Nodular Lesion of Periventricular area on Brain Magnetic Resonance Imaging / 대한소아신경학회지

Cytomegalovirus(CMV) is the most common cause of congenital viral infections. CMV infection occurs in 0.4% to 2.4% of all live births. CMV causes thin cerebral cortices, diminished volume of white matter, and delayed myelination, bringing on encephalopathy, which may be manifested as seizures in some cases. CT findings in CMV encephalopathy present as irregular intracranial calcifications of the periventricular area. Recently, there are increasingly more reports about MRI findings in CMV encephalopathy and common findings of the encephalopathy are periventricular cysts and dilated lateral ventricles. We experienced a case of congenital CMV encephalopathy with patchy, nodular lesions of the periventricular area on magnetic resonance imaging(MRI). We report this case with a review of associated literature.

A Case of Parathyroid Carcinoma Invading Thyroid Gland as Solitary Nodular Form / 대한내분비학회지

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism and commonly metastasize to lymph node, lung, liver, and bone. In Korea, there has been no report of distant metastasis in parathyroid carcinoma except for one case of pulmonary metastasis. A 58-year-old man presenting with weakness, nausea, and a palpable thyroid nodule visited our hospital. Elevated serum calcium and parathyroid hormone (PTH) concentration allowed the diagnosis of hyperparathyroidism. Two discrete masses were identified by neck ultrasound scan, computed tomography (CI') and Tc-Sestamibi scan in the left lobe of thyroid gland and ipsilateral parathyroid gland. So multiple endocrine neoplasia (MEN) type 2A" was suspected initially, but postoperative histological diagnosis was left parathyroid carcinoma with solitary nodular lesion invading left thyroid gland. He was successfully treated with left parathyroidectomy and left thyroid lobectomy.

Diffuse Nodular Lung Disease / 결핵

The diffuse nodular lung lesion has a diagnostic problem and should be made differential diagnosis. A chest X-ray of 62-year-old male patient with dyspnea showed small-sized scattered multinodular lesion on entire lung field. Bronchoalveolar lavage and transbronchial needle aspiration showed the non-specific findings, so open lung biopsy was done and revealed bronchioloalveolar cell carcinoma.

Clinical Research of Intracranial Rodular Lesions on Brain CT Scan in Children

To make guideline to the diagnosis and treatment and of the intracranial nodular lesions, the authors made a clinical analysis on 81 pediatric patients who had showed nodular lesions on brain CT scan at Severance Hospital from Mar. 1979 to Feb. 1989 and the results were summarized as follows. 1) The peak incidence of intracranial nodular lesions was found in the 2nd decade(61.7%). There was no sexual difference. 2) The most common clinical symptom was seizure(92.6%) and the predilection site was parietal area. The nodular enhancing type on brain CT scan showed not only the most common type but also the most favorable clinical course. 3) As the etiology of the intracranial nodular lesions, tuberculosis, paragonimiasis, cysticercosis, tumor(meningioma), and aspergillosis were confirmed or suspected, but tuberculosis was the most common. CSF routine examination, chest PA, PNS X-rays, skin test for paragonimiasis and tuberculosis, CSF ELISA test for cysticercosis and paragonimiasis should be routine as the diagnostic studies. 4) We made treatment principle for intracranial nodular lesions. In cases that initial brain CT scan show low density or calcified density without contrast enhancement, we treat those patients with anticonvulsants and steroid with regular check-up. If the lesion increases in size or new enhancement develops on follow up CTY scan, medications for the suspected etiology should be added. In cases that initial brain CT scan show enhancing lesions, treatment is started with anticonvulsants and medications for the etiology with regular check up. If the lesion increase in size on follow up CT scan or seizure is uncontrolled. Surgery should be considered.