A circuit from dorsal hippocampal CA3 to parvafox nucleus mediates social novelty preference deficits induced by chronic social defeat stress / 中国药理学与毒理学杂志

OBJECTIVE The preference for social novelty is crucial to the social life of humans and rodents.However,the neural mechanisms underlying social novelty preference are poorly understood.Dorsal hippocampal CA3(dCA3)is an important brain area that responds to social defeat stress,and the neural circuitry of dCA3→lat-eral septum(LS)participates in the context-associated memory.Meanwhile,the parvafox nucleus(PFN)Foxb1+ neurons regulate the defensive reaction to life-threaten-ing situations.Therefore,we investigate a cell-specific cir-cuit of dCA3CaMKⅡα+→dorsal LSGABA+→PFNFoxb1+ in social novelty preference.METHODS Chronic social defeat stress(CSDS)and three-chamber social interaction test were performed in adult male C57BL/6J mice to detect social behaviors.Optogenetic and chemical-genetic experiments were conducted to regulate the circuit.RESULTS CSDS reduced the preference for social nov-elty in mice and the response of dCA3CaMKⅡα+ neurons dur-ing approach to an unfamiliar mouse was impaired by CSDS.Optogenetic inhibition of dCA3CaMKⅡα+→dLS pro-jection reduced the preference for the unfamiliar mouse versus a familiar mouse.Meanwhile,optogenetic activa-tion of dCA3CaMKⅡα+→dLS projection rescued the prefer-ence for social novelty of CSDS-treated mice.Manipula-tions dLSGABA+→PFN projection activation regulated the preference for social novelty in mice.Optogenetic activa-tion of PFNFoxb1+→lPAG projection reduced the prefer-ence for a familiar C57BL/6J mouse versus a novel object in control mice.CSDS decreased the excitability of dCA3CaMKⅡα+ neurons by up-regulation of Kir2.4(Kcnj14)expression.CONCLUSION Our present study suggest-ed that activation of a cell-specific circuit of dCA3CaMKⅡα+→dLSGABA+→PFNFoxb1+→lPAG reverses the deficits of social novelty preference in defeated mice,and inhibition of this circuit reduces the preference for social novelty.The cir-cuit that regulates the preference for social novelty deficits may provide a new information for the potential therapeu-tic targets for neuropsychiatric diseases.

Quality issues in reviews written by medical postgraduate students: investigation and countermeasures / 中华医学教育探索杂志

Objective:To investigate the quality issues in medical reviews written by medical postgraduate students, and to provide a reference for improving the quality of medical reviews written by such students.Methods:A total of 141 medical reviews written by the medical postgraduate students from various affiliated hospitals of Shanghai Jiao Tong University School of Medicine from 2018 to 2022 were collected, and the quality of these medical reviews was evaluated in terms of topic selection and writing expression skills. As for topic selection, a self-designed innovative questionnaire (hereinafter referred to as topic questionnaire) was used to collect the evaluation of external experts, and as for writing expression, the reviews were assessed based on the criteria in relevant literature from the aspects of the outline of the review, the timeliness of references, analysis and evaluation, and the quality of the text. EPIDATA 3.2 was used to input data, and SPSS 20.0 was used for the chi-square test.Results:A total of 135 (96%, 135/141) valid questionnaires were collected in this study, and the results showed that 70% (94/135) of the review topics lacked novelty. The assessment of writing skills showed that 95% (128/135) of the reviews had outdated references, and 68% (92/135) lacked focus, hierarchy or logic in outline, which accounted for a higher proportion than the reviews with analysis and evaluation issues (59%, 80/135) and text quality issues (61%, 83/135) ( P<0.05). Conclusion:There are many quality issues in the medical reviews written by medical postgraduate students, such as a lack of novelty in topic selection and low overall quality of outlines. In order to improve the abilities of scientific research among medical postgraduate students, universities and supervisors should strengthen the guidance of innovative thinking in topic selection and enhance the training of writing expression skills, such as scientific analysis and logic.

Cross-Modal Interaction and Integration Through Stimulus-Specific Adaptation in the Thalamic Reticular Nucleus of Rats / 神经科学通报·英文版

Stimulus-specific adaptation (SSA), defined as a decrease in responses to a common stimulus that only partially generalizes to other rare stimuli, is a widespread phenomenon in the brain that is believed to be related to novelty detection. Although cross-modal sensory processing is also a widespread phenomenon, the interaction between the two phenomena is not well understood. In this study, the thalamic reticular nucleus (TRN), which is regarded as a hub of the attentional system that contains multi-modal neurons, was investigated. The results showed that SSA existed in an interactive oddball stimulation, which mimics stimulation changes from one modality to another. In the bimodal integration, SSA to bimodal stimulation was stronger than to visual stimulation alone but similar to auditory stimulation alone, which indicated a limited integrative effect. Collectively, the present results provide evidence for independent cross-modal processing in bimodal TRN neurons.

Editorial: Originalidad y contexto / Editorial: originality and context

Resumen Aragón-Vargas, L.F. (2021). Editorial: Originalidad y contexto. PENSAR EN MOVIMIENTO: Revista de Ciencias del Ejercicio y la Salud, 19(2), 1-4. En este editorial se reflexiona sobre el grado de originalidad que se debe exigir a los manuscritos que se reciben para publicación en las revistas académicas y, más específicamente, en Pensar en Movimiento.

Abstract Aragón-Vargas, L.F. (2021). Editorial: originality and context. PENSAR EN MOVIMIENTO: Revista de Ciencias del Ejercicio y la Salud, 19(2), 1-4.This editorial presents some reflections on how much originality should be required from those manuscripts submitted for publication in academic journals and, more specifically, in Pensar en Movimiento.

Resumo Aragón-Vargas, L.F. (2021). Editorial: Originalidade e contexto. PENSAR EN MOVIMIENTO: Revista de Ciencias del Ejercicio y la Salud, 19(2), 1-4. Neste editorial é feita uma reflexão sobre o grau de originalidade exigida dos manuscritos recebidos para publicação nas revistas acadêmicas e, mais especificamente, na Pensar en Movimiento.

Diversity,novelty,antimicrobial activity,and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert / 药物分析学报

Three hundred and twenty endophytic actinobacterial strains were isolated from psammophytes collected from Taklamakan Desert and identified.Among them,three strains already had been identified as new species of two genera and sixteen isolates showed relatively low 16S rRNA similarities＜98.6％to validly described species.Seventy-five of the isolates were selected as representative strains to screen antibacterial activity and mechanism.Forty-seven strains showed antagonistic activity against at least one of the indicator bacteria.Two Streptomyces strains produced bioactive compounds inducing DNA damage,and two Streptomyces strains produced bioactive compounds with inhibitory activity on protein biosynthesis.Notably,the strain Streptomyces sp.8P21H-1 that demonstrated both strong antibacterial activity and inhibitory activity on protein biosynthesis was prioritized for exploring new antibiotics.Under the strategy of integrating genetics-based discovery program and MS/MS-based molecular networking,two new streptogramin-type antibiotics,i.e.,acetyl-griseoviridin and desulphurizing gri-seoviridin,along with known griseoviridin,were isolated from the culture broth of strain 8P21H-1.Their chemical structures were determined by HR-MS,and 1D and 2D NMR.Desulphurizing griseoviridin and griseoviridin exhibited antibacterial activities by inhibiting translation.

Comparative Behavioral Correlation of High and Low-Performing Mice in the Forced Swim Test

Behavioral analysis in mice provided important contributions in helping understand and treat numerous neurobehavioral and neuropsychiatric disorders. The behavioral performance of animals and humans is widely different among individuals but the neurobehavioral mechanism of the innate difference is seldom investigated. Many neurologic conditions share comorbid symptoms that may have common pathophysiology and therapeutic strategy. The forced swim test (FST) has been commonly used to evaluate the “antidepressant” properties of drugs yet the individual difference analysis of this test was left scantly investigated along with the possible connection among other behavioral domains. This study conducted an FST-screening in outbred CD-1 male mice and segregated them into three groups: high performers (HP) or the active swimmers, middle performers (MP), and low performers (LP) or floaters. After which, a series of behavioral experiments were performed to measure their behavioral responses in the open field, elevated plus maze, Y maze, three-chamber social assay, novel object recognition, delay discounting task, and cliff avoidance reaction. The behavioral tests battery revealed that the three groups displayed seemingly correlated differences in locomotor activity and novel object recognition but not in other behaviors. This study suggests that the HP group in FST has higher locomotor activity and novelty-seeking tendencies compared to the other groups. These results may have important implications in creating behavior database in animal models that could be used for predicting interconnections of various behavioral domains, which eventually helps to understand the neurobiological mechanism controlling the behaviors in individual subjects.

Comparative analysis of subject novelty detection methods in medical literature / 中华医学图书情报杂志

Objective To study the feasibility of novelty detection model in assessing the subject novelty of medical literature and comparatively analyze the advantages and disadvantages of words-overlap algorithm and co-words-based inverse file frequency quantitative algorithm. Methods Two novelty detection models were established for the 8 research subjects in PubMed-covered literature. The feasibility of two novelty detection models in assessing the subject novelty of medical literature was assessed according to the subject novelty of literature analyzed by experts, ROC curves and AUC values. Results Words-overlap algorithm showed that the fluctuating amplitude of subject novelty was rather high, which can thus reflect the difference between the contents in literature on the data. ROC curves and AUC values-based analysis revealed a high accuracy of words-overlap algorithm for judging the novelty of literature while co-words-based inverse file frequency quantitative algorithm displayed a low accuracy for judging the novelty of literature. Conclusion The novelty of literature detected with the two novelty detection methods is moderately related. The mean novelty value detected with the two novelty detection methods is of statistical signifi-cance. However, the novelty of literature detected with words-overlap algorithm is higher than that detected with co-words-based inverse file frequency quantitative algorithm.

Inovação na ciência, inovação na psicanálise / Innovation in science, innovation in psychoanalysis

Resumo: O artigo examina o estatuto da inovação nos dias de hoje, relacionando-o aos procedimentos da ciência e procurando ver as suas consequências para as concepções de sujeito e de ato. Toma o complexo curso da história da ciência, recorrendo a unidades de tempo amplas, para demonstrar as importantes marcas deixadas ao longo dos últimos séculos. Mostra em seguida que, a despeito de aparentemente afastadas de nosso cotidiano, as operações matemáticas alteram a ordem do discurso onde o sujeito se constitui. Conclui que a inovação se torna obrigatória na ciência, o que paradoxalmente a afasta do novo que faz surgir o sujeito.

Abstract: The paper examines the category of innovation in the light of its relations to scientific procedures. It then observes the consequences of the current use of innovation for the conception of a speaking subject and the act he/she performs. It takes the complex course of the history of science using wide time units to demonstrate the important traces left by the progress of science in the past centuries. It then shows that despite seeming far from our day to day life, operations carried on with mathematics, and especially geometry, constitutes the intellectual structure in which we are involved. It concludes that innovation having become mandatory paradoxically wards off the very novelty responsible for bringing around the speaking subject.

A fully automatic method for recognizing hand configurations of Brazilian sign language

Abstract Introduction Sign language is a collection of gestures, postures, movements, and facial expressions used by deaf people. The Brazilian sign language is Libras. The use of Libras has been increased among the deaf communities, but is still not disseminated outside this community. Sign language recognition is a field of research, which intends to help the deaf community communication with non-hearing-impaired people. In this context, this paper describes a new method for recognizing hand configurations of Libras - using depth maps obtained with a Kinect® sensor. Methods The proposed method comprises three phases: hand segmentation, feature extraction, and classification. The segmentation phase is independent from the background and depends only on pixel value. The feature extraction process is independent from rotation and translation. The features are extracted employing two techniques: (2D)2LDA and (2D)2PCA. The classification employs two classifiers: a novelty classifier and a KNN classifier. A robust database is constructed for classifier evaluation, with 12,200 images of Libras and 200 gestures of each hand configuration. Results The best accuracy obtained was 96.31%. Conclusion The best gesture recognition accuracy obtained is much higher than the studies previously published. It must be emphasized that this recognition rate is obtained for different conditions of hand rotation and proximity of the depth camera, and with a depth camera resolution of only 640×480 pixels. This performance must be also credited to the feature extraction technique, and to the size standardization and normalization processes used previously to feature extraction step.

Promoting innovative development of scientific literature novelty assessment based on comprehensive evaluation / 中华医学图书情报杂志

After the limitations of modeling scientific literature novelty assessment were analyzed in light of the de-velopment of scientific literature novelty assessment, comprehensive assessment of the innovations and overall develop-ment of the projects was proposed with combined traditional literature retrieval and multivariate analysis according to the competitive information theory and integrated comprehensive assessment theory in combination with bibliometrics and special case analysis of literature novelty assessment.

Difficult position of scientific literature novelty assessment and its way out / 中华医学图书情报杂志

After the position and difficulties of traditional scientific literature novelty assessment were described, the changing policy environment of scientific literature novelty assessment and its effect on its developmen were ana-lyzed, with suggestions put forward for the reform of scientific literature novelty assessment, including seeking poli-cy support and taking advantage of the opportunity, deep mining and optimizing explanation, dividing team and in-tegrating resources, taking measures in light of the situation and transforming service.

Construction of the Medical Field Oriented Retrieval Thesaurus / 医学信息学杂志

The paper analyzes the problems of the specialized databases and search engines during document retrieval and the reasons for constructing retrieval thesaurus in the field of medical field,and establishes a retrieval thesaurus jointly reviewed by sci-tech novelty assessment and subject specialists by taking sci-tech novelty report of the sci-tech novelty station of the Ministry of Education since 2014 as the data sources.The thesaurus applies to sci-tech novelty assessment,document retrieval teaching and other fields,which can also be promoted in other fields.

Case retrieval in PubMed for improving the retrieval effectiveness of literature novelty assessors / 中华医学图书情报杂志

The retrieval of literature novelty assessment projects was divided into unlimited retrieval and limited retrieval according to the retrieval terms.The redundant retrieval mode,complicated retrieval process,poor compatibility,and lack of summary that affect the retrieval effectiveness of literature novelty assessors were analyzed.The overall retrieval ability and literature analysis ability of literature novelty assessors were put forward for improving their retrieval effectiveness.

Characteristic traditional Chinese medicine literacy of literature novelty assessors of traditional Chinese medicine / 中华医学图书情报杂志

After the present situation and characteristics of literature novelty assessment of traditional Chinese medicine were described, the importance of characteristic traditional Chinese medicine literacy of literature novelty assessors of traditional Chinese medicine was elaborated, the effect of literature novelty assessors on the literature novelty assessment of traditional Chinese medicine and the training of literature novelty assessors were studied in order to provide reference for other colleges and universities or scientific research institutions.

Embedded subject service based on general practical medical literature novelty assessment course / 中华医学图书情报杂志

After the development of domestic embedded subject service and its domestic and foreign main models were described, following suggestions were put forward: thinking approach teaching contents and multiple elementary assessment system should be designed based on OBE theory with medical postgraduate general practical medical literature novelty assessment course as its starting point, excellent students should be trained as scientific information detectors by improving their information literacy and practical ability through small scale blended teaching, the professional bottleneck of librarians and talent team construction should be solved by cultivating subject service team for different subjects and strengthening the contacts between different subjects.

Problems in novelty assessment of doctorial dissertations in Chinese Academy of Traditional Chinese Medi-cine and measures for their solution / 中华医学图书情报杂志

The novelty assessment of doctorial dissertations in Chinese Academy of Traditional Chinese Medicine was outlined, the selected topics and innovative characteristics of doctorial dissertations in Chinese Academy of Tra-ditional Chinese Medicine from 2012 to 2016 were summarized, the problems in their novelty assessment were ana-lyzed, and the following measures were put forward for improving the novelty assessment of doctorial dissertations, such as adjusting its timetable, finding its new model, carrying out its training for doctors, and attaching highly concern to it by the governments.

Connotation of "precision novelty assessment of literature" and its empirical analysis / 中华医学图书情报杂志

After the concept of"precision novelty assessment of literature" was proposed by integrating"precision"into novelty assessment of literature, the connotation of"precision novelty assessment of literature" was elaborated, including full communication with the trustee, working out comprehensive strategies for "precision novelty assess-ment of literature", writing accurate and complete retrieval process of"precision novelty assessment of literature", appropriate and objective report of "precision novelty assessment of literature". Empirical analysis was then con-ducted by elaborating the concept of"precision novelty assessment of literature" in order to enrich the theory for the novelty assessment of scientific literature and further improve its practical level.

Connotation of "precision novelty assessment of literature" and its empirical analysis / 中华医学图书情报杂志

After the concept of"precision novelty assessment of literature" was proposed by integrating"precision"into novelty assessment of literature, the connotation of"precision novelty assessment of literature" was elaborated, including full communication with the trustee, working out comprehensive strategies for "precision novelty assess-ment of literature", writing accurate and complete retrieval process of"precision novelty assessment of literature", appropriate and objective report of "precision novelty assessment of literature". Empirical analysis was then con-ducted by elaborating the concept of"precision novelty assessment of literature" in order to enrich the theory for the novelty assessment of scientific literature and further improve its practical level.

Precision scientific literature novelty assessment promotes the development of clinical medicine in the era of precision medicine / 中华医学图书情报杂志

Medical literature novelty assessment plays a unique role in the advances of medical sciences. The idea of precision medical literature novelty assessment was thus proposed according to the precision medicine program of army general hospitals, which has promoted the development of clinical medicine in our hospital by finding out the precision points of literature novelty followed by precisely retrieving.

Concept of Deep-level and Precise Service Recommendation for Users of Sci-tech Novelty Retrieval in the Environment of Big Data / 医学信息学杂志

By integrating data of sci-tech novelty retrieaval and internet data,the paper makes a precise analysis of the potential demands,interest,interest,tendency,preferences and habits of users of novelty retrieval.From the perspective of big data technology,it analyzes the feasibility of designing targeted and deep-level services for mass user data,puts forward the framework and method of conducting deep-level and precise service recommendation based on users of sci-tech novelty retrieval,and studies the opportunity to provide these users with deep-level and precise services.