RESUMO
Resumen Objetivo. Evaluar el impacto de capacitaciones impartidas por estudiantes de la Universidad Colegio Mayor de Cundinamarca (UCMC) referentes al VIH en población habitante de calle asistente a un centro de acogida en la ciudad de Bogotá D.C. Materiales y método. Se realizaron encuestas en las que se definieron los factores socio-demográficos, los hábitos y los conocimientos sobre el VIH de la población. Se examinaron 47 individuos de los cuales el 92% eran hombres y el 12,78% de toda la población fue seropositiva para VIH, así mismo, de ésta población el 33,33% de los individuos no recordaban el número de parejas sexuales que habían tenido en el último año. Respecto a las charlas sobre VIH por parte de los estudiantes de la UCMC el 61,40% las calificaron como buenas. Resultados. Con base en el estudio se pudo evidenciar que en la población habitante de calle es necesaria una intervención educativa, dado que esto reduce el riesgo de infección por VIH y el desarrollo de la enfermedad, a la vez que se puede promover la reintegración social de esta comunidad.
Abstract HIV is a world problem, according to the World Health Organization 36.7 million people infected by this virus, of which the greatest risk occurs in people who are in a state of neglect, by example the inhabitant street. It is estimated in Bogotá D.C., the inhabitant street population near 9,614 characters. The objective was to evaluate the Impact of training given by students of the Universidad Colegio Mayor de Cundinamarca (UCMC) concerning HIV Population Inhabitants street attending the reception Centre in the City of Bogotá D.C. To collect information conducted surveys that defined the socio-demographic factors, Habits, and Knowledge About HIV population. 47 individuals of which 92% were men and 12.78% of the entire population was seropositive HIV, also, of this population they were examined 33.33% of individuals did not remember the number of sexual partners in the last year. Regarding the talks on HIV by students UCMC the 61.40% rated this as the good. Base with the study itself was evident that's inhabitant street population is required educational intervention, given a this Risk of HIV infection and disease development reduce the time you can promote reintegration this type of social community.
Assuntos
Humanos , Saúde Pública , Vírus , Epidemiologia , HIVRESUMO
Background and purpose: Factor that binds to the inducer of short transcripts of human immuno-deficiency virus-1 (FBI-1) in a variety of malignant tumors showed high expression levels, which may be closely related to tumor proliferation and differentiation, angiogenesis, metastasis, but its relationship with breast cancer has not been fully elucidated. The purpose of this study was to investigate the expression of FBI-1 in breast cancer cells, and to study the effect of FBI-1 gene expression on the proliferation of breast cancer cells and its possible mechanism. Methods:Real-time fluorescent quantitative polymerase chain reaction (RTFQ-PCR) and Western blot analysis were applied to detect FBI-1 expression in normal human mammary epithelial cell line MCF-10A and breast cancer cell MCF-7. RNA interference method was used to down-regulate FBI-1 expression in MCF-7 cells. The cell proliferation was measured by CCK-8 kit and colony formation assay. RTFQ-PCR and Western blot were used to detect the expression of FBI-1 and NF-κBp65 in MCF-7 cells before and after the interference of FBI-1 expression. Results: The expression of FBI-1 was higher in breast cancer cells than that in normal human mammary epithelial cells (P<0.05). The effects of FBI-1 down-regulation inhibited proliferation in MCF-7 cells (P<0.05). At the same time, after inhibition of FBI-1, the NF-κBp65 mRNA and protein expression levels were significantly decreased (P<0.05). Conclusion: FBI-1 is highly expressed in breast cancer cells. Down-regulated FBI-1 expression can inhibit the proliferation of breast cancer cells,and its mechanism may be related to the inhibition of NF-κB signaling pathway.