Primary renal ewing sarcoma in a 15-year-old female: Case report

@#Extraskeletal Ewing sarcoma (EES) is a rare tumor that primarily affects children and lacks specific clinical signs. Diagnosis is confirmed through imaging techniques, histology, and molecular diagnostics. Treatment typically involves surgical intervention and chemotherapy. We present the case of a 15-year-old female with a history of abnormal mass enlargement in the right flank area. An initial diagnosis of Wilms tumor was made, and the patient underwent a right open radical nephrectomy. However, the tumor recurred eight months after nephrectomy, necessitating a metastasectomy. Chemotherapy was started to immediately target the tumor recurrence. Next-generation sequencing done on the open radical nephrectomy and metastasectomy samples revealed the presence of the EWSR1-FLI1 fusion gene in both specimens, confirming the final diagnosis to be primary renal Ewing sarcoma. Despite undergoing a right open radical nephrectomy for the primary tumor site, a metastasectomy during tumor recurrence, and chemotherapy, the patient’s prognosis remained poor.

Laparoscopic radical nephrectomy and open radical nephrectomy for stage T2 renal cell carcinoma patients: A comparison of clinical outcomes / 第二军医大学学报

Objective: To compare the efficacy of laparoscopic radical nephrectomy(LRN) and open radical nephrectomy (ORN) for clinical stage T2 renal cell carcinoma. Methods: A total of 138 patients underwent radical nephrectomy for renal cell carcinoma, including 63 by LRN and 75 by ORN. Renal cell carcinoma was pathologically confirmed in all the patients. The patients were followed up for 5-36 months, with a median of 24 months. The surgical blood loss, operation time, and time of starting food postoperatively, and hospital stay were compared between the two groups. Results: The operation tíme was 90- 385 min (a mean of [213 ± 61. 6] min) for LRN and 55-320 min (a mean of [173 ± 52. 3] min)for ORN (P = 0. 000). The blood losswas 30-1 600 ml (a mean of [220±291. 8] ml) for LRN and 50-1 400 ml (a mean of [319 ±244. 1] ml) for ORN (P = 032). The fasting period of surgery was 1-4 d (a mean of [2. 4±0. 82] d) for LRN and 2-5 d (amean of [3. 1±1. 02] d) for ORN(P = 0. 000). The hospital stay was 4-15 d (a mean of [7. 3±2. 50] d) for LRN and 6-15 d (amean of [9. 3±2. 25] d) for ORN (P = 0. 000). Conclusion: The efficacy of LRN is similar to that of ORN. LRN has the advantages of minimal invasiveness and rapid postoperative recovery. The complication of LRN is similar to ORN, and it might be an alternative treatment for clinical T2 stage renal cell carcinomas.