Pseudo-orthostatic tremor as a manifestation of vitamin B12 deficiency: A case report

@#Vitamin B12 deficiency has long been known to present with various neurological manifestations, but only rarely presents as movement disorders, especially in adults. We present the case of a 30-year-old vegan male presenting with tremors on both legs when standing which was relieved by vitamin B12 supplementation. To the best of our knowledge, this is the first documented case of slow orthostatic tremor or pseudo-orthostatic tremor caused by vitamin B12 deficiency.

Recent advances in diagnoses and treatments of orthostatic tremor / 中华神经医学杂志

Orthostatic tremor is a rare movement disorder. It is characterized by unsteadiness when standing and it can be relieved when sitting or walking. It is confirmed on neurophysiological recording by the presence of a fast tremor of 13-18 Hz in the legs and trunk. Due to a small number of cases reported, most clinicians lack of understanding of the disease, resulting in misdiagnosis. This review summarizes the clinical characteristics, pathophysiology, differential diagnoses, and treatment strategies of orthostatic tremor to improve the understanding of the disease among clinicians.