The correlation between the expression of LncRNA-OVAAL and the recurrence and prognosis of uterine papillary serous carcinoma after operation / 中国医师杂志

Objective To investigate the relationship between long non-coding ovarian adenocarcinoma amplified RNA (LncRNA-OVAAL) and tumor recurrence and prognosis in uterine papillary serous carcinoma (UPSC).Methods From May 2012 to November 2016,32 patients with UPSC in our hospital were selected as observation group,and 30 patients with other benign diseases were selected as control group.Real-time polymerase chain reaction (PCR) was used to detect the expression of LncRNA-OVAAL in the enrolled patients.The receiver operating characteristic (ROC) curve was used to analyze the cutoff value of LncRNA-OVAAL.The relationship between LncRNA-OVAAL expression and clinicopathological features was analyzed.The cumulative survival rate was calculated and survival analysis was performed.The Cox risk regression model was used to analyze the single-factor and multi-factor analysis of prognosis and overall survival rate.Results The expression of LncRNA-OVAAL in patients with UPSC was elevated,which was related to age,vascular invasion,menopause,recurrence and preoperative serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) (P ＜ 0.05).High expression of LncRNAOVAAL was a risk factor for postoperative recurrence and overall survival in patients with UPSC (P ＜0.05).Conclusions The high expression of LncRNA-OVAAL has a certain evaluation value for predicting postoperative recurrence and prognosis in patients with UPSC.

Adenocarcinoma sincrónico de alto grado de endometrio y ovario; a propósito de un caso clínico / Synchronous high-grade adenocarcinoma of the endometrium and ovary; about a clinical case

RESUMEN El cáncer sincrónico endometrial y ovárico (SEOC) representa alrededor de un 5-10% de las neoplasias de endometrio y ovario. Cuando no existe extensión locorregional y presentan un patrón histológico de bajo grado, actúan como si fueran dos tumores primarios independientes, en lugar de comportarse como un cáncer en estadio avanzado. Los mecanismos para diferenciar si su origen es metastásico o por el contrario, son tumores primarios independientes conlleva una gran dificultad y ha generado una importante controversia dentro del estudio de este tipo de neoplasias. En este artículo, exponemos el caso clínico de una paciente de 46 años que presenta un tumor sincrónico de endometrio y ovario en estadio IA, desconocido hasta el estudio histológico de la pieza quirúrgica.

ABSTRACT Endometrial and ovarian synchronous cancer (SEOC) accounts for about 5-10% of endometrial and ovarian neoplasms. When there is no local extension and they present a low-grade histological pattern, they act as if they were two independent primary tumours, instead of behaving as an advanced stage cancer. Therefore, the differentiation of its origin (metastatic or independent primary tumours) is fraught with difficulty and has generated a significant controversy in the study of this type of neoplasms. In this article, we present the clinical case of a 46-year-old patient presenting a synchronous tumor of the endometrium and ovary in IA stage, unknown until the histological study of the surgical sample.

Abdominal Wall Metastasis of Uterine Papillary Serous Carcinoma in a Post-Menopausal Woman: A Case Report

Uterine papillary serous carcinoma (UPSC) is an aggressive form of endometrial cancer characterized by a high recurrence rate and poor prognosis. We report a case of a 58-year-old post-menopausal woman with an abdominal wall metastasis in stage IA UPSC. After surgical staging, she did not receive additional adjuvant therapy. An egg sized palpable mass developed in the right lower abdomen after 8 months. Both Abdominopelvic computed tomography (CT) and positron emission tomography (PET)-CT revealed a metastatic lesion in the abdominal wall. Hence, surgical excision was performed. The pathological findings showed metastatic UPSC with clear resection margin. After the diagnosis of UPSC metastasis in the abdominal wall, she received chemotherapy utilizing paclitaxel and carboplatin. After 3 years, no evidence of recurrence was found. Therefore, we suggest that even when UPSC is confined to the endometrium without lymph node metastasis and without lymphovascular invasion, chemotherapy should be considered as a postoperative adjuvant therapy.

Which is worse: uterine papillary serous carcinomas or carcinosarcomas? / 부인종양

OBJECTIVE: It is clear that uterine carcinosarcomas and uterine papillary serous carcinomas (UPSC) have an adverse impact on outcome, but whether carcinosarcomas are worse than UPSC is unclear. The purpose of this study is to compare the pathology, survival, and disease recurrence of patients with carcinosarcomas to patients with UPSC. METHODS: The medical records of patients diagnosed with carcinosarcomas and UPSC between 1996 and 2009 at Samsung Medical Center were retrospectively analyzed. Information from pathology reports, site of relapse, time to recurrence, and death was obtained. The survival analysis was performed using the Kaplan-Meier method. RESULTS: Thirty seven patients with carcinosarcomas and 38 patients with UPSC were identified during the study period. There was no significant difference in clinical characteristics including age, body mass index, proportion with advanced stage disease, rate of optimal debulking, and adjuvant treatment used. In addition, the pathology showed no significant difference in tumor size, myometrial involvement, lymphovascular invasion, peritoneal cytology, cervical invasion, and lymph node involvement. Patients with carcinosarcomas had similar patterns of relapse as the patients with UPSC. There was no difference in the progression-free and overall survival between the carcinosarcomas and UPSC patients (p=0.804 and p=0.651, respectively). CONCLUSION: Patients with carcinosarcomas had similar clinicopathological features compared to the patients with UPSC.

A serous borderline tumor of the fallopian tube detected incidentally / 대한산부인과학회지

Serous borderline tumors (SBTs) of the fallopian tube are very rare and usually diagnosed incidentally. We present a case of SBTs of left fallopian tube incidentally diagnosed during laparoscopic hysterectomy because of increasing symptomatic myoma. Preoperative abdomino-pelvic CT revealed 6 cm sized myoma in uterus but no gross lesion on both adnexa. Preoperative serum CA 125 was 18.9 U/mL. At laparoscopy a 2.0 cm sized polypoid mass protruding from the ampulla portion of the left tube was found. The contralateral fallopian tube, ovaries and uterus were unremarkable except previous known uterine myoma. Exploration of the abdomino-pelvic cavity has shown no abnormal finding. Intraoperative frozen biopsy to tubal mass suggested borderline malignancy but did not completely rule out tubal carcinoma. So, standard laparotomy staging operative procedures such as hysterectomy, bilateral salpingooophorectomy, omentectomy, lymph node dissection, and appendectomy were performed. Serous borderline tumor limited tube was confirmed in permanent pathology. In English literature, only 7 cases have been reported. And the current case is the first report in Korean as far as we know. Treatment for SBTs of fallopian tube is complete excision like borderline ovarian tumor. Recurrence was not reported with up to 6 year follow up in 7 cases.

Expression and significance of WT-1,P53,MMP-9 and TIMP-2 in ovarian papillary serous carcinoma / 重庆医科大学学报

Objective:To investigate the expression and significance of WT-1,P53,matrix metalloproteinase-9(MMP-9)and tis-sue inhibitor of metalloproteinase-2(TIMP-2)in ovarian papillary serous carcinoma.Methods:WT-1,P53,MMP-9 and TIMP-2 were detected by S-P immunohistochemitry in 52 cases of ovarian papillary serous carcinoma,and compared with 15 cases of primary peritoneal papillary serous carcinoma and 11 cases of uterine papillary serous carcinoma.Results:The positive expres-sion rates of WT-1 in ovarian papillary serous carcinoma,peritoneal papillary serous carcinoma and uterine papillary serous car-cinoma were 96.2%,93.3%,and 36.4%,respectively.The positive expression rates of P53 were 78.8%,80%,and 72.7%,respec-tively.The positive expression rates of MMP-9 and TIMP-2 were 90.4%,93.3%,100%,and 92.3%,93.3%,100%,respectively.The area integrated optical density(AIOD/?m)2of WT-1、P53、MMP-9 and TIMP-2 analyzed by image analyzer in low differentiation group of ovarian serous carcinoma were high than those in high differentiation group(P

A Clinical Study of 25 Cases of Uterine Papillary Serous Carcinoma / 대한산부인과학회지

OBJECTIVE: Uterine papillary serous carcinoma (UPSC) has been recognized as an aggressive tumor characterized by deep myometrial invasion and reported high recurrence and low survival rates. METHODS: We retrospectively investigated the clinicopathologic findings and analyzed the survival rate and prognostic factors in 25 patients with UPSC who were surgically staged at the oncology department between January 1994 and December 2003. RESULTS: The mean age of the cases was 55.8 (range: 45-69) years. The most frequent presenting symptom was abnormal uterine bleeding (88%). According to FIGO staging, seven of the cases were stage I, six of the cases were stage II, eleven of the cases were stage III, and one case was stage IV. Mean follow up period is 42.7 months (range: 9-123 months). Overall survival rate was 80 percent. The recurrence was seen in 5 patients (25%). CONCLUSION: Univariate analysis showed that invasion of uterine serosa, ovarian and tubal metastasis, and positive peritoneal washing cytology were significantly associated with prediction of prognosis. In multivariate analysis, tubal metastasis was an independent prognostic factor for overall survival.

Uterine Papillary Serous Carcinoma (UPSC): A Retrospective Study Comparing with Endometrioid Adenocarcinoma / 대한산부인과학회지

OBJECTIVE: Uterine papillary serous carcinoma (UPSC) is uncommon endometrial cancer, but clinically significant because of its poor prognosis. The aim of this study was to identify clinical and pathologic characteristics of patients with uterine papillary serous carcinoma and to evaluate the overall survival compared with endometrioid adenocarcinoma of uterus. METHODS: Twenty one patients with uterine papillary serous carcinoma and 332 patients with endometrioid adenocarcinoma who were surgically staged at the Asan medical Center between 1989 and 2004 were analyzed with review of clinical characteristics; pathologic findings, surgical stages, treatment modalities, prognosis and survival time from medical records and pathologic reports. RESULTS: In 21 patients with uterine papillary serous carcinoma, the median age at the time of diagnosis was 60.9 years (range, 38-81 years), which occurred in 18 postmenopausal women (85.7%) and usually presented with abnormal vaginal bleeding (75%). Obesity, diabetes, hypertension, or a history of hormone replace therapy, known as risk factors of endometrial cancer, were not so frequently associated. In 21 patients with uterine papillary serous carcinoma, there were 10 patients (47.6%) with stage I disease, 2 (9.5%) with stage II, 5 (23.8%) with stage III, and 4 (19.1%) with stage IV. The 3-year survival rate was 97.4% in endometrioid adenocarcinoma and 43.1% in uterine papillary serous carcinoma in all stages. Among 21 patients with uterine papillary serous carcinoma who had surgical staging, 3 patients received only operation and 9 patients received radiation therapy after surgery, 6 patients received chemotherapy and 3 patients received concurrent chemotherapy and radiation therapy. CONCLUSION: Patients with uterine papillary serous carcinoma showed a higher rate of abdominal metastasis and poor prognosis compared to patients of endometrioid adenocarcinoma. Therefore, complete surgical staging like in cases of ovarian cancer is vital in determining disease prognosis and vigorous adjuvant therapies are required.

Clinicopathologic analysis of patients with uterine papillary serous carcinoma / 부인종양

OBJECTIVE: The aims of this study were to identify clinical and pathologic characteristics of patients with uterine papillary serous carcinoma (UPSC) and to evaluate the overall survival. METHODS: Sixteen patients with FIGO stage I-IV UPSC who were surgically staged except one at the Asan medical Center between 1995 and 2004 were identified. For each patient, medical records, pathology reports and treatment modality were reviewed. The Kaplan-Meier method was used to generate survival data. RESULTS: There were 8 patients with stage I disease, 1 with stage II, 3 with stage III, and 4 with stage IV. The median age at the time of diagnosis was 64 years (range, 38-81 years). It occurred in 14 postmenopausal women who usually present with abnormal vaginal bleeding. Obesity, diabetes, hypertension, or a history of hormone replace therapy, known as risk factor of endometrial cancer, were not usually seen. Of the 15 patients who had surgical staging, 12 patients received adjuvant therapy, 2 patients no adjuvant therapy and 1 patient chemotherapy before and after surgery. 1 patient with advanced stage received chemotherapy without surgical staging. The 3-year survival rate was 21.4% and the median survival time for patients with early stage and advanced stage was 31.0 and 14.6 months respectively. CONCLUSION: In this patients with UPSC, there was a high proportion with abdominal metastasis and poor prognosis compared to endometrioid adenocarcinoma. Therefore, complete surgical staging like in case of ovarian cancer is vital in determining their prognosis and vigorous adjuvant therapies are required.

Paratesticular Papillary Serous Tumor of Low Malignant Potential: A Case Report

Paratesticular papillary serous tumors have been rarely reported, and they often resemble ovarian serous tumors of borderline malignancy. We experienced a case of papillary serous tumor in the left paratestis of a 39-year-old man. This is the second case reported in the Korean literature. The tumor, which was found incidentally during an operation for a hydrocele, was composed of papillary structures lined by cuboidal to columnar epithelial cells that displayed low cytologic atypia and frequent psammoma bodies.

A Case of Papillary Serous Carcinoma of Endometrium / 대한산부인과학회잡지

Uterine papillary serous carcinoma (UPSC) has been recognized as an aggresive tumor with early and deep myometrial invasion, frequent lympho-vascular space involvement, and a high relapse rate. It has also been shown that deep myometrial invasion cannot predict the risk of extrauterine disease. UPSC accounts for 2-10% of all endometrial cancer and generally occurs in postmenopausal women (mean age 66 years) who usually present with abnormal vaginal bleeding. Obesity, diabetes, hypertension, or a history of previous hormone replacement treatment, known as risk factors of endometrial cancer, are not usually seen in women with UPSC. In this paper, we present a case of uterine papillary serous carcinoma with obesity, hypertension, diabetes. The initial endometrial biopsy showed an endometrioid adenocarcinoma but the result of postoperative pathologic finding revealed UPSC with extension to less than half thickness of the muscle layer and involvement of pelvic lymph node.

Papillary Serous Carcinoma in Rectum-a Case of Complete Remission of Bulky Pelvic Disease after Platinum-paclitaxel Combination Chemotherapy

Papillary serous carcinoma of the peritoneum (PSCP) is a primary tumor of peritoneal lining (mesothelioma) of the abdomen and is histologically difficult to differentiate from papillary serous carcinoma of the ovary. It is very rare tumor that involves the surface of the pelvic and/or abdominal peritoneum. Most patients with this tumor have been treated with optimally surgical cytoreduction and postoperative chemotherapy. However, long term survival has not been achieved in many studies. In recent years, platinum-paclitaxel combination therapy was reported as a effective initial therapy for recurrent PSCP. We have experienced one case of recurrent PSCP which was successfully treated with heptaplatin and paclitaxel. We report the toxicity and long term result of the patient.

A Case of Postirradiation Uterine Papillary Serous Carcinoma / 대한산부인과학회잡지

Uterine papillary serous carcinoma is a morphologically distinct variant of endometrial carcinoma that is associated with an aggressive behavior with rapid progression and high recurrence, and poor response to salvage treatment. The most common type of malignancy developing in the uterus after radiation therapy is the malignant mixed mullerian tumor, however, the papillary serous carcinomas have rarely been reported.Here we report a case of uterine papillary serous carcinoma which had developed 7 years after radiation therapy for invasive cervical cancer.

Papillary Serous Cystadenoma of Borderline Malignancy Arising from a Paramesonephric Parovarian Cyst: A case report

Primary malignant parovarian epithelial tumors are extremely rare, with only 56 cases previously reported in the world literature. Most parovarian epithelial tumors are of paramesonephric (Mullerian) origin. In this article, we report the first case in the Korean literature of papillary serous cystadenoma of borderline malignancy from paramesonephric parovarian cyst. This case presented here is of particular interest since this neoplasm is rare. A 48-year-old female underwent a hysterectomy with bilateral adnexectomy and pelvic lymph node dissection for a cystic tumor of the right parovarian area. The tumor, measuring 13 cm in diameter, was apart from the ovaries, fallopian tubes and uterus. The cyst wall had well-developed smooth muscle layers. The cyst was lined with mildly atypical ciliated and non-ciliated low columnar cells compatible with those of paramesonephric origin. From the inner surface of the cyst several cauliflower-like structures projected into the lumen. They were of a predominantly papillary architecture covered by atypical epithelial cells with piling-up and occasional glandular growth. No destructive stromal invasion was identified.

A Case of Primary Papillary Serous Carcinoma of the Peritoneum / 대한산부인과학회잡지

Primary papillary serous carcinoma of the peritoneum(PPSCP) is vere rare. It has been suggested that PPSCP derives from embryonal coelomic epithelium with m llerian ducts potential. PPSCP can develop from a single or multicentric focus. The clinical and histologic disease entities are similar to those of primary papillary serous carcinoma of the ovary, but PPSCP involves the ovarian surface only minimally(microscopic disease) or spares the ovaries entirely. We have experienced a case of primary papillary serous carcinoma of the peritoneum and report this case with brief review of the concerned literature.

Research advances in uterine papillary serous carcinoma / 中国癌症杂志

Uterine papillary serous carcinoma is a special pathological type of endometrial cancer. It is similar to ovarian papillary serous carcinoma in histology and can have distant metastasis when it is still confined to the endometrium. As it is very aggressive and has a rather poor prognosis,complete surgical staging is necessary in the treatment,assisted by radiotherapy and chemotherapy. In this review,the author discussed the recent research advances in uterine papillary serous carcinoma.

Two Cases of Primary Papillary Serous Peritoneal Carcinoma / 대한산부인과학회잡지

The well-documented but rare primary papillary serous peritoneal tumors are difficult problems for the pathologist and the clinician. The peritoneal serous papillary tumors were morphologically identical to serous ovarian tumor of equivalent grade. Because of their unusual location, these tumor are often classified as mesothelioma or advanced epithelial ovarian carcinoma. We experienced two cases of primary papillary serous peritoneal carcinoma and report with brief review of literature.

A Case Report of Papillary Serous Peritoneal Carcinoma Arising from the Rectum

Papillary serous peritoneal carcinoma(PSPC) is a rare malignancy that arises in the peritoneum and histologically resembles papillary serous carcinoma of the ovary. If peritoneal carcinomatosis occurs in the absence of an obvious primary tumor site and is associated with a papillary serous pathology, we may be dealing with the distinct entity of PSPC of extraovarian origin. Radiological findings suggesting the diagnosis are diffuse microcalcifications in the peritoneum, which occur in relation to psammoma bodies. The Ca-125 is most often abnormal and, not uncommonly, markedly elevated. The diagnosis requires that the surgeon identify grossly normal ovaries or minimal surface involvement. If PSPC is confirmed, a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and aggressive debulking surgery should be carried out, followed by cisplatin-based chemotherapy. We report a case of PSPC arising from the rectum in a 41 year-old woman.

Four Cases of Autosomal Recessive Polycystic Kidney Disease

Endometrial papillary serous carcinoma (EPSC) is a distinct variant of endometrial adenocarcinoma that histologically resembles ovarian serous papillary adenocarcinoma and has an aggressive clinical course. Usually, the tumor is diagnosed at the advanced stage. The tumor has well confused with metastatic ovarian tumor of identical histology. Dignosis of EPSC should be considered when the cervico-vaginal smear reveals numerous papillary clusters of tumor cells with macronucleoli and psammoma bodies. Recently, we have experienced two cases of EPSC diagnosed on cervico-vaginal smears, which revealed characteristic cytologic features including numerous papillary clusters of tumor cells with macronucleoli. The cytologic diagnoses were confirmed on histologic sections.

Cytologic Features of Endometral Papillary Serous Carchinoma / 대한세포병리학회지

Endometrial papillary serous carcinoma (EPSC) is a distinct variant of endometrial adenocarcinoma that histologically resembles ovarian serous papillary adenocarcinoma and has an aggressive clinical course. Usually, the tumor is diagnosed at the advanced stage. The tumor has well confused with metastatic ovarian tumor of identical histology. Diagnosis of EPSC should be considered when the cervico-vaginal smear reveals numerous papillary clusters of tumor cells with macronucleoli and psammoma bodies. Recently, we have experienced two cases of EPSC diagnosed on cervico-vaginal smears, which revealed characteristic cytologic features including numerous papillary clusters of tumor cells with macronucleoli. The cytologic diagnoses were confirmed on histologic sections.