Papular Xanthoma in a Child / 대한피부과학회지

Papular xanthoma is a rare normolipemic xanthomatous skin disease that primarily occurs in adults. While this rare disorder has been documented in children before, all but one case reported in the literature involved a normal lipid profile. The skin lesions of adult papular xanthoma appear to be persistent, whereas in children they generally self-heal within 1~5 years. Here, we describe a typical case of papular xanthoma in a 22-month-old boy who presented with numerous reddish-yellow papulonodules, 2~8 mm in diameter, mainly on the face, but also on the upper and lower extremities, and trunk, for 15 months. The lipid profile was normal, and histological studies showed a diffuse monomorphous infiltrate of foamy cells, with some Touton giant cells, in the dermis. The foamy cells stained positive for Cluster of Differentiation (CD) 68, and the Periodic Acid Schiff (PAS) stain was negative. These findings are consistent with the diagnosis of papular xanthoma.

Primary Papular Xanthoma in an Infant / 대한피부과학회지

Papular xanthoma is one of the clinicopathologic variants of normolipemic cutaneous non-Langerhans cell histiocytosis. It is a very rare condition that is characterized by non-confluent, yellowish papules located on the face, trunk and mucous membranes with no internal involvement. It has been predominantly reported in adults but childhood cases were also recently seen. We report a typical case of papular xanthoma in a 14-month-old boy who presented numerous yellow-brown papules on the face, arm and buttock. On histologic findings, it showed typical features of papular xanthoma.

A Case of Papular Xanthoma Developed in an Adult / 대한피부과학회지

Papular xanthoma is a normolipemic xanthomatosis, characterized by nonconfluent papular to papulonodular eruptions on the face, trunk, extremities and occasionally mucous membranes. Histologically, there was an infiltration of foamy histiocytes and Touton type giant cells in the dermis without inflammatory cells or a pure histiocytic component. But, occasional lymphocytes were interspersed between the foamy macrophage. No systemic involvement could be found and the blood lipid profiles were normal. We report a case of papular xanthoma in a 30-year-old man with typical clinical, histopathologic findings.

A Case of Papular Xanthoma / 대한피부과학회지

Papular xanthoma is a very rare disorder. It is characterized by an eruption of papular and papulonodular xanthomatous elements located on the head, trunk, and extremities. No systemic involvement can be found and blood lipid levels are normal. Histologically there is an infiltrate composed of foamy histiocytes and Touton giant cells in the dermis and characteristically no initial nonlipidized histiocytic phase can be traced in the early development of the lesion. We present a case of papular xanthoma in a 18-month-old boy with typical clinical, histopathologic findings.

A Case of Papular Xanthoma / 대한피부과학회지

Papular xanthoma is a newly classified type of normolipemic xanthoma that resembles juvenile xanthogranuloma and xanthoma disseminatum. Papular xanthoma is asymptomatic multiple yellowish papules with granulomatous lesion composed of foam cells and few giant cells, with scarce inflammatory cell infiltration. We report a case of papular xanthoma in a 3-year-old girl who showed typical clinical manifestation. She had multiple discrete, 0.2 to 0.5cm sized elevated dome-shaped yellowish papules on the trunk and face for 2years. Histopathologic findings showed granulomatous changes mainly composed of foam cells and few histiocytes, in the dermis.