RESUMO
The incidence of chronic kidney disease (CKD) gradually increased.With the decline of renal function,CKD patients gradually appear intractable hypertension,anemia,malnutrition,calcium and phosphorus metabolic disorders,micro-inflammatory State and other complications which can seriously affect the survival and prognosis.Among them,calcium and phosphorus metabolism disorders are more common complications,and can lead to high incidence of cardiovascular disease and increased mortality.Recent studies have shown that Klotho protein has anti-inflammatory,anti-oxidative stress,anti-apoptosis and antifibrosis effects.It can inhibit renal fibrosis and regulate calcium and phosphorus metabolism disorders in patients with CKD.This article reviews the regulatory role of Klotho protein in calcium and phosphorus metabolism.
RESUMO
Objective To study the relationship between femur and serum calcium and phosphorus content in rat with osteoporosis. Methods We developed animal models with rat experienced bilateral oophorectomy and used inductively coupled plasma atomic emission spectrometry (ICP-AES) to determine calcium and phosphorus content in femur and serum of experimental group as well as control group. Results Calcium and phosphorus contents in femur in experimental group were significantly lower than that in control group[Ca: (218.59 ± 10.43) mg/L vs (253.32 ±7.54)mg/L;P:( 127.82 ±3.71 )mg/L vs ( 142. 18 ±5.99 ) mg/L, P ＜0. 01], but in serum experimental group it was significantly higher than that in control group [Ca: (99.45 ±0.76)mg/L vs (97.56±0.80) mg/L;P: (67.68 ± 1.63) mg/L vs (60.00 ± 1.18) mg/L,P ＜0. 01]. Conclusion Femur calcium and phosphorus levels were significantly reduced, which was related to the increase of serum calcium and phosphorus content, and it was one of the causes of osteoporosis.