1.
Chinese Journal of Gastroenterology
;
(12): 560-563, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-1016326
RESUMO
Piezo proteins, including Piezo1, Piezo2, are non-selective mechanosensitive ion channels. They have similar biophysical characteristics, which can transform mechanical signals into biological electric signals. Studies have shown that Piezo proteins play important roles in mechanical-relevant physiological functions and pathophysiological changes of a variety of organs, including gastrointestinal tract. This article reviewed the relationship between Piezo1/2 proteins and digestive system diseases, and discussed the roles of Piezo1/2 under mechanical stress in the development of digestive system diseases, so as to provide a novel target in the study of pathogenesis and treatment of relevant digestive system diseases.