RESUMO
Background: Elevated plasma levels of low-density lipoproteins are an important risk factor for heart diseases and the premature start of atherosclerosis. Objectives: The aim of this study is to assess the correlation between lipid profile and platelets parameters of blood donors and to find out the association of platelet volume indices with heart diseases. Materials and methods: A cross-sectional study was done involving blood donors (n=80) from the Department of Transfusion Medicine, King George’s Medical University Lucknow (June 2015-December 2015). Medical history from blood donors by questionnaire was taken and lipid levels were analyzed by blood samples. Results: Out of 80 blood samples 30 were hyperlipidemic and 50 were normolipidemic. There was statistical significance in sex age and weight (p=0.05) in hyperlipidemic groups. Platelet parameters were also significantly higher in hyperlipidemic groups as well as a significant association was found between hyperlipidemia on the basis of the donor’s weight and platelet parameters (p=0.05). Conclusion: Elevated platelet volume indices are an increased risk of heart diseases with hyperlipidemia. Further studies on larger sample size need to establish the observation.
RESUMO
Background: Coronary artery disease is mainly caused by atherosclerosis and its complications. Platelets and their activity have an important role in initiation of atherosclerotic lesions and coronary thrombus formation. Larger platelets are enzymatically and metabolically more active and have a higher potential thrombotic ability as compared with smaller platelets. Aim: To compare platelet volume indices in acute myocardial infarction, unstable angina, stable angina pectoris and healthy controls and to investigate the importance and role of platelet volume indices in acute coronary syndrome. Materials and methods: This was cross-sectional study of 100 patients includes 25 patients with acute myocardial infarction, 25 patients with unstable angina, 25 patients with stable angina and 25 healthy controls. Venous samples would be drawn at the time of admission before initiation of treatment. Platelet volume indices were assayed within 30 minutes of blood collection, using auto analyser. Results: Platelet volume indices were found to be higher among ACS (acute myocardial infarction and unstable angina) patients as compared to non ACS (stable angina and healthy control). For example mean platelet volume was significantly higher in patients with AMI (9.8±0.86) and unstable angina (9.5±0.84) as compared to stable angina (8.4±0.58) and healthy control (8.2±0.56). Conclusion: Measurement of platelet volume indices may be of benefit in detecting those patients at higher risk for acute coronary syndrome in future.