RESUMO
Background: Inflammation is a protective response of the body to the harmful stimuli. Inflammation can be either acute or chronic, always associated pain, redness and loss of function. Vanilla planifolia (VP) is the aromatic plant, as per literature, it has anti-inflammatory activity, which has not been tested as per modern medicinal parameters. Non-steroidal anti-inflammatory drugs are commonly used for the treatment but have many adverse effects such as gastritis, hepatitis etc. Therefore, there is always a search for new safe drug. Aim and Objectives: The aim of the study is to evaluate the anti-inflammatory activity of VP seeds in acute and chronic animal model of inflammation. Materials and Methods: Rats weighing 150–200 g of either sex were included in the study. Acute Anti-inflammatory activity tested with carrageenan-induced paw edema and chronic with cotton pellet-induced granuloma model. Animals were divided into five groups – Gr-I Control, Gr-II Vehicle control, Gr-III Diclofenac sodium, Gr-IV (VPLD), Gr-V (VPHD). Drug treatment was given 1 h before carrageenan injection. Paw volume measured at different time interval with plethysmometer. In chronic model, drug treatment was given for 7 days after pellet implantation. On 8th day, pellets removed and dried in oven. Weight of wet and dry pellets from all the groups compared with vehicle control. Data obtained was analyzed with Graph pad prism 6. Results: Reduction in paw volume started in all drug treated groups after 1 h of treatment. Paw volume was significantly reduced (P < 0.001) in group III, IV & V in 5 h. reached to near normal. In chronic model, VPLD showed decrease in wet pellet (P < 0.01) and dry pellet weight (P < 0.05) significantly. VPHD was more effective in reducing wet pellet (P < 0.001) and dry Pellet weight (P < 0.01). Similar results were seen on the left side. Conclusion: VP seed extract showed promising anti-inflammatory effect in both models of inflammation.
RESUMO
Background: Inflammation can be classified as either acute or chronic. NSAIDs are the most commonly prescribed drugs worldwide, and mostly have adverse effects. Lercanidipine a CCB of (DHPs) blocks the mediators of inflammation and has additional anti-inflammatory potential. Tanacetum parthenium (Feverfew) extracts have also shown its anti-inflammatory effects in experimental studies. It was decided to study anti-inflammatory effects of Lercanidipine and Tanacetum parthenium which was compared with Indomethacin. The present study was aimed to evaluate and compare the anti-inflammatory effect of lercanidipine and Tanacetum parthenium with Indomethacin in rats.Methods: The study was conducted in the department of Pharmacology UPUMS, Saifai after getting approval from IAEC.A total of 24 animals divided into 4 groups of six (n=6) animals each group were used, and the anti-inflammatory effects of both drugs were evaluated by Carrageenan-induced Paw Edema Model by digital Plethysmometer in rats, drug administration was with the same frequency.Results: The result of the present study had shown that lercanidipine produced anti-inflammatory effect compared to Indomethacin, while its efficacy in reducing paw edema was better at 1st hour, 48 and 72 hours while at 2nd hour and 3rd hour Indomethacin had better efficacy. Tanacetum parthenium also decreased paw edema at 2nd, 3rd, 48 and 72 hour while at 1st hour no effect was seen. However, at 72 hours, shown good efficacy compared to lercanidipine and Indomethacin.Conclusions: Lercanidipine could be a promising anti-inflammatory drug in reducing the inflammation and edema. However, herbal drug (Tanacetum parthenium) has shown anti- inflammatory efficacy when compared with Indomethacin. Both drugs were found safe during our study.
RESUMO
This study was carried out to evaluate the anti-inflammatory and analgesic activities of the stem bark extract in albino rats. Evaluation of the anti-inflammatory activity was done using fresh egg albumin induced rat paw edema with a plethysmometer, while the analgesic effect was determined using the analgesymeter mechanically induced pain. The methanolic extract of the stem bark of Anthocleista djalonensis was evaluated at 100mg/kg, 200mg/kg, and 400mg/kg through the oral route. Indomethacin (10mg/kg) was used as standard reference anti-inflammatory and analgesic drug. Preliminary phytochemical screening showed the presence of tannins, flavonoids, saponins and deoxysugars. The different doses of the extract significantly inhibited the egg albumin induced inflammation (P<0.05) in a non-dose dependent manner. The extract also significantly inhibited the pain (P<0.05) mechanically induced on the rat paw by the analgesymeter. The findings of this study showed that the plant possess significant anti-inflammatory and analgesic activities.
RESUMO
The inflammatory process is the response to an injurious stimulus. It can be evoked by a wide variety of noxious agents (e.g., infections, antibodies, physical injuries). Many nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, phenylbutazone, indomethacin etc. are in clinical use but all these are not completely devoid of adverse effects2. In this study, the anti-inflammatory activity of 0. sanctum alone and in combination with indomethacin was studied using formalin-induced rat paw edema. Aqueous extract of O. sanctum (200mg/kg, 300mg/kg or 400mg/kg) was administered alone and in combination with indomethacin (25mg/kg) to separate group of rats and paw volume was measured by plethysmometer and compared with control group. All the test groups showed significant (P<0.05) anti-inflammatory effect in formalin-induced rat paw edema. The reduction of edema by 0. sanctum was better than that of the standard anti-inflammatory drug, indomethacin and on co-administration marginally improved the anti-inflammatory profile of indomethacin. O.sanctum possesses significant anti-inflammatory activity probably due to inhibition of both cyclooxygenase and lipooxygenase pathways of arachidonic acid metabolism (dual inhibitory property).