RESUMO
The usage of benzodiazepines, the major class of anxiolytic drugs is invariably accompanied by many side effects like sedation and myorelaxation leading to incoordination of movements. Intense research is going on all over the world to find out most effective and safer anxiolytic compounds. In the present study, portilaca oleracea has been investigated in detail for its anxiolytic in mice. The anxiolytic activity was screened by using two well validated methods namely elevated plus maze, stair case test. Portilaca oleracea displayed a dose-dependent anxiolytic effect similar to diazepam in the animal models of anxiety as revealed by a significant increase in the time spent in open arms of the elevated plus maze and significant reduction in the number of rearing responses in staircase test, the results of the present study have identified the novel anxiolytic compound.
RESUMO
To investigate the antiarrthritic activity of petroleum-ether extract of Portulaca oleracea. The petroleum-ether extract of Portulaca oleracea was subjected to preliminary phytochemical screening. Acute toxicity studies were carried out in Male Wistar rats and anti-arthritic activity by Fruends adjuant arthritis model. Phytochemical evaluation revealed the presence of alkaloids, tannins, flavonoids, saponins and triterpenoids. Acute toxicity studies showed that the extract was non-toxic upto a maximum dose of 2000 mg/kg body weight. Petroleum-ether extract exhibited significant anti-arthritic activity. The present study indicates that the petroleumether extract of Portulaca oleracea has a potential anti-arthritic activity can be used as anti-arthritic drug.