Use Of Biological Parameters To De-Escalate Chemoradiation In Hpv Associated Squamous Cell Carcinoma Of Different Subsites

Human papillomavirus infection is now a well-established cause of many common cancers like cervical, other anogenital, and head and neck cancers. The mortality and morbidity rate associated with these cancers constitute a major burden especially for the underdeveloped and developing countries of the world, where they are more common. Traditionally, all these subsites are being treated with different chemoradiation protocols with variable results. Toxicities associated with the standard high dose chemoradiation protocols form a major obstacle in the completion of treatment for these patients and often affects the outcome negatively. Personal experience and published reports and reviews suggests that HPV associated squamous cell cancers are a distinct biological sub group of cancer which can be treated safely with reduced intensity of chemoradiation. The establishment of a similar de-intensified chemoradiation protocol for all HPV associated squamous cell carcinoma will certainly improve the quality of life of such patients.

Effects Of Natural Products On Body Weight And Biochemical Parameters In Healthy Rats

The present study was undertaken to evaluate effect of natural products i.e. Anthocephalus indicus; KADAM, roots, Hibiscus rosa sinensis roots, Tinospora cordifolia stem and Cassia tora seeds in normal healthy rats. In this study ethanol extract of above mentioned medicinal plants had macerated with aqueous gum acacia (2%, w/v) suspension and fed orally (500 mg/kg bw p.o.) to male adult healthy normal rats of Charles Foster strain for 30 days. Results of this study showing that alcoholic extracts caused no any signicant reduction in blood glucose, total cholesterol, triglyceride, phospholipids, free fatty acid, lipid peroxide and no signicant increased in post heparin lipolytic activity, but on the other hand as per pre-existing data and my published studies in diabetic patients and diabetic experimental animals showed that extracts exerting all above effects signicantly. That's why it is very clear here if healthy person will take natural products, it never cause hypoglycemia, hypolipidemia and under weight. Natural products also not cause any signicant change on hepato-specic parameters. Thus from this study we conclude that, natural products are safe, non toxic and free from side effects, in comparison to synthetic drugs.

Experimental Validation Of Anti-Diabetic And Antioxidant Potential Of T. Cordifolia Stems (M.): An Indigenous Medicinal Plant

This case control study had been carried out to evaluate antidiabetic and antioxidant activities of Tinospora cordifolia (T. cordifolia; family: Menispermaceae) against streptozotocin induced diabetes in experimental rats to scientifically validate its use against diabetes. Ethanolic extract of T. cordifolia stem extract and standard drug (glibenclamide) macerated with aqueous gum acacia (2%, w/v) suspension and fed orally to streptozotocin induced male adult diabetic rats of Charles Foster strain for 30 days. Biochemical parameters in normal, diabetic control, standard (600µg/kg bw p.o.) and treated (500 mg/kg bw p.o.) animals group were determined and compared. Treatment of streptozotocin induced diabetic rats with ethanolic extract caused significant (p<0.001) reduction in blood glucose, total cholesterol, triglyceride, phospholipids, free fatty acid, lipid peroxide and significant increased (p<0.001) post heparin lipolytic activity. Furthermore, the stem extract (100-400 µg) when tested for its antioxidant activity in vitro, shown significant (p<0.001) inhibit the generation of super oxide anions in enzymic system a, in enzymic system b, non enzymic system and hydroxyl radicals in enzymic system and non-enzymic system. The results of the present study demonstrated antidiabetic antidyslipidemic and anti oxidant activities of T. cordifolia stem extract which could help in prevention of diabetic- dyslipidemia and related complications.

Hypolipidemic activity of Hibiscus rosa sinensis root in rats.

The hypolipidemic activity of Hibiscus rosa sinensis (family Malvaceae) root extract was studied on triton and cholesterol-rich high fat diet (HFD) induced models of hyperlipidemia in rats. In triton WR-1339-induced hyperlipidemia, feeding with root extract (500 mg/kg body wt/day p.o.) exerted lipid-lowering effect, as assessed by reversal of plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) and reactivation of post-heparin lipolytic activity (PHLA) of plasma. The other model was fed with cholesterol-rich HFD and root extract (500 mg/kg body wt/ day p.o.) simultaneously for 30 days. This also caused lowering of lipid levels in plasma and liver homogenate and reactivation of plasma PHLA and hepatic total lipoprotein lipase activity. The hypolipidemic activity of Hibiscus rosa sinensis root was compared with a standard drug guggulipid (200 mg/kg body wt/day p.o.), a known lipid- lowering agent in both models. Histopathological findings in rat liver supported the protective role of H. rosa sinensis root extract in preventing cholesterol-rich HFD-induced hepatic steatosis.