RESUMO
Objective: The co-processd excipient containing microcrystalline cellulose (MCC) and glycerol monostearate (GMS) was prepared. The humidity resistance of MCC used in Chinese materia medica (CMM) was improved and the possibility of this co-processd excipient used in the preparation of CMM tablet was explored. Methods: The co-processd excipient containing MCC and GMS was prepared by applying spray drying method. The moisture absorption, flow ability, compressibility, and disintegration were as the indexes to optimize the best preparation of co-processd excipient through uniform design methodology. The powder characteristic of co-processd excipient was investigated and the microstructures were studied by scanning electron microscope (SEM), differential scanning calorimeter (DSC), X-ray diffraction (XRD), and Flourier transform infra-red (FTIR) spectroscopy. The effect of co-processd excipient on the moisture absorption of spray drying power of Xinyueshu, epimedium total flavonoids, and wolfberry extracts was investigated. The in vitro dissolution of hyperside and ferulic acid in Xinyueshu Tablet was studied. Results: The results showed that the optimal conditions of the preparation consisted of 1 portion of GMS, 12 portions of MCC, and 200 portions of water, emulsionzing temperature of 66°C, and mixing time of 1 h. It was confirmed that the chemical constituents in co-processd excipient were not changed after spray drying with smaller particle size and better fluidity. The co-processd excipient can improve the moisture absorption of spray drying power of Xinyueshu, epimedium total flavonoids, and wolfberry extracts without affecting the disintegration of MCC. Conclusion: The co-processd excipient prepared has good humidity resistance and it is confirmed to have application prospect.
RESUMO
AIM: The powder characteristic, water and ethanol extraction amount, extraction amount of active ingredient ferulic acid were comparatively studied between crude powder and micronized powder to explore the application of micronization technology to Angelica Sinennsis. METHODS: Angelica Sinennsis powder was characterized by laser diffraction analyzer and scanning electron microscopy, the angle of repose and bulk density were measured, the water and ethanol extraction were quantified by cooled and heated extraction, the active ingredient ferulic acid was detected by RP HPLC after it released from Angelica Sinennsis. RESULTS: The differences of particle characteristic and surface morphology between the crude and superfine powder were significant, however, water and enthanol extraction amount were not increased markedlky, the dissolution amount of ferulic acid was almost the same. CONCLUSION: Pharmaceutical characteristic of Angelica Sinennsis powder is affected by micronization, but its bioavailability is not improved. Micronization technology is not suitable to Angelica Sinennsis.