Analysis of risk factors for early stent thrombosis in the Chinese population: A multicenter restrospective study / 世界急诊医学杂志（英文）

@#BACKGROUND: The predictive scoring systems for early stent thrombosis (EST) remains blank in China. The study aims to evaluate the risk factors and conduct a prediction model of EST in the Chinese population. METHODS: EST was defined as thrombosis that occurs within the first 30 days after primary percutaneous coronary intervention (PCI). Patients from ten Chinese hospitals diagnosed as stent thrombosis (ST) from January 2010 to December 2016 were retrospectively included as the study group. A control group (1 case:2 controls) was created by including patients without ST, major adverse cardiovascular events, or cerebrovascular events during follow-up. The present study evaluated 426 patients with single-vessel lesions and ultimately included 40 patients with EST and 80 control patients, who were included to identify factors that predicted EST and to develop a prediction scoring system. The other 171 patients without integrated 1:2 pair were used for external validation. RESULTS: EST was independently associated with a low hemoglobin concentration (adjusted odds ratio [OR] 0.946, 95% confidence interval [95% CI] 0.901-0.993, P=0.026), a high pre-PCI Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score (OR 1.166, 95% CI 1.049-1.297, P=0.004), and a DAPT (DAPT) duration of <30 days (OR 28.033, 95% CI 5.302-272.834, P<0.001). The simple EST prediction score provided an area under the curve (AUC) of 0.854 (95% CI 0.777-0.932, P<0.001) with 70.0% sensitivity and 90.0% specificity, and 0.742 (95% CI 0.649-0.835, P<0.001) with 54.5% sensitivity and 81.0% specificity for external validation dataset. CONCLUSIONS: EST may be independently associated with DAPT discontinuation within 30 days, a low hemoglobin concentration, and a high SYNTAX score. The scoring system also has a good ability to predict the risk of EST and may be useful in the clinical setting.

Early Prediction of Bronchopulmonary Dysplasia in Premature Infants less than 34 Weeks of Gestational Age

PURPOSE: A variety of postnatal therapies have been and will be evaluated for prevention or treatment of neonatal chronic lung disease. A simple method for early selection of the highest risk infants would optimize intervention trials. The purpose of this study was to develop an scoring system to predict the bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: A retrospective analysis of clinical, respiratory and radiographic variables of a 2.5-year experience was done with data of preterm infants less than 34 weeks of gestation admitted to Ewha Womans University Hospital from January 1998 to July 2000. RESULTS: Multiple regression analysis identified four independent predictors of BPD; longer duration of assisted ventilation, lower Apgar score at 5 minute, higher PaCO2 at birth, presence of patent ductus arteriosus after 7 days. A clinical predictive scoring system (CPSS) was developed with these four predictors. CONCLUSION: We have come up with a CPSS for early identification of preterm infants with high risk of BPD. A prospective study is on going to evaluate the predictivity of this scoring system.

Early Prediction of Bronchopulmonary Dysplasia in Premature Infants less than 34 Weeks of Gestational Age

PURPOSE: A variety of postnatal therapies have been and will be evaluated for prevention or treatment of neonatal chronic lung disease. A simple method for early selection of the highest risk infants would optimize intervention trials. The purpose of this study was to develop an scoring system to predict the bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: A retrospective analysis of clinical, respiratory and radiographic variables of a 2.5-year experience was done with data of preterm infants less than 34 weeks of gestation admitted to Ewha Womans University Hospital from January 1998 to July 2000. RESULTS: Multiple regression analysis identified four independent predictors of BPD; longer duration of assisted ventilation, lower Apgar score at 5 minute, higher PaCO2 at birth, presence of patent ductus arteriosus after 7 days. A clinical predictive scoring system (CPSS) was developed with these four predictors. CONCLUSION: We have come up with a CPSS for early identification of preterm infants with high risk of BPD. A prospective study is on going to evaluate the predictivity of this scoring system.