Pre-and post-donation ferritin level of blood donors attending University of Calabar Teaching Hospital, Donor Clinic in Southern Nigeria

While trying to save the patient via blood transfusion, the safety of the blood donor is paramount. This study evaluated the pre-and post-donation ferritin and packed cell volume (PCV) of donors attending University of Calabar Teaching Hospital.Method: The study adopted descriptive longitudinal approach. A total of 18 donors with age range of 18 ­48years were enrolled and followed up for 30 days post-donation. The serum ferritin was analyzed using ELISA method while the PCV was analyzed using the microhematocrit method. Difference between means was performed using repeated measure ANOVA while post hoc was done using Bonferroni adjustment. Prediction of return to baseline values were performed using logistic regression. Alpha value was placed at 0.05 There was a decline in ferritin and packed cell volume from pre-to post-donation. The decline in ferritin was imminent until day 14 when recovery was initiated. Significant difference was observed between the pre-donation ferritin and the rest of the days except day 30. There was also a decline in PCV from pre-donation all through with recovery noticeable after day 7. The PCV of the pre-donation was only comparable to the day 30 post-donation. Approximately 5.6% (n=1) of the subjects was iron deficient pre-donation.Approximately 25% (n=4) of the subject have returned to baseline PCV while 0% of the subjects have returned to baseline ferritin at day 30 post-donation.Conclusion: For the safety of the donor, donation interval should be widened, and iron supplement followed up

Analysis on pre-donation blood testing in blood services in Chongqing / 中国输血杂志

【Objective】 To provide data reference for the implementation of the homogenization of pre-donation blood testing by investigating the relevant situation of pre-donation blood testing in various blood services in Chongqing and analyzing their differences. 【Methods】 A questionnaire covering the basic information of pre-donation blood testing items, quality control and the management of deferral donors was developed, and issued to 19 blood services in Chongqing through E-mails by Chongqing Society of Blood Transfusion. The data collected were sorted, revised and analyzed. 【Results】 A total of 19 questionnaires from 19 blood services(including 1 blood center, 1 sub-center, 6 central blood stations and 11 central blood banks) were collected. All of the pre-donation blood test items of 19 blood services met the Blood Donor Health Test Requirements. Hemoglobin, blood group, ALT and HBsAg testing were carried out by 19 blood services, anti-TP testing by 15, and lipid blood testing by 11, using different detection methods and reagents. Significant differences were found in the frequency and rules of internal quality control for quantitative testing items. In addition, the deferral time and re-recruitment strategy of deferral blood donors were also significantly different. 【Conclusion】 There were differences in the management of pre-donation blood testing and blood donor management after blood donation among blood services in Chongqing. Further standardization was needed to realize regional homogenization and guarantee blood safety and the safety of blood donors.

​The Evaluation of Predonation Blood Donor Deferrals in a Tertiary Care Center: A 3-year Study

Background: Blood safety a major issue in the field of transfusion medicine. Persons who are disqualified or rejected fromdonating blood are known as “deferred” donors. Deferrals lead to loss of precious blood/components available for transfusion.For preventing this, we should be having knowledge of the causes of deferral and their frequency. To make blood transfusionsafe for the patients, many safety measures are undertaken and the most important is a selection of the suitable blood donors.Hence, it is important to analyze the reasons and rate for donor deferral and retain the motivated donors.Aims: This study aims to evaluate and analyze the reasons of predonation deferrals.Materials and Methods: In this retrospective study, causes of donor deferral were evaluated retrospectively including both inhospital donations (and outdoor camp donations) including voluntary and replacement donors from January 2016 to December2018 in the State of the Art Model blood bank of Dr. B. R. Ambedkar Memorial Hospital and Pt. Jawaharlal Nehru MemorialMedical College, Raipur, Chhattisgarh, India.Results: Among 53,245 donors registered, 1894 (3.56%) were deferred from blood donation. Temporary deferrals weresignificantly higher than permanent deferral. The most common reasons for temporary deferral were anemia, followed byunderweight, recent medication, high blood pressure (BP), and low BP and so on. The common causes for permanent deferralincluded being overage, diabetes, asthma, heart disease, hepatitis B surface antigen positivity, and epilepsy and so on.Conclusion: Creating public awareness on common causes of donor deferral may help to lower the deferral rates as well aspromote the retention of potential donors.

Analysis of rapid detection of Treponema pallidum antibody before voluntary blood donation and strategy optimization / 国际检验医学杂志

Objective To evaluate the performance of fast Treponema pallidum(TP) detection in voluntary blood donors and optimize the strategy for pre-donation screening.Methods Before blood donation,the gold standard TP test strip was used to make a fast detection.After blood donation,the TP-ELISA was used to test the blood.Then,analyze the donors′ anti-TP positive rate,times and intervals of donating,false positive and negative of TP fast detection.Results From 2014 to 2015,among 73 990 donors who were tested by using fast TP detection,0.71% of them(529 donors) were positive.Among the positive donors,89.2% of them(472 donors) were first-time blood donors.35 donors′ donating intervals were more than 3 years,who accounted for 61.4% of the donors who had donated for more than once.The numbers of the false positive obtained from fast TP detection were 5 and the false negative was 15.By applying the fast TP detection before blood donation,the rate of anti-TP positive had been declined from 0.71% to 0.17%.Conclusion The rejection rate of TP positive can be significantly reduced by using fast TP detection before blood donation.The fast TP detection can be used to optimize the pre-donation screening and promote blood donation service efficiency and level,while donating times and intervals of the blood donors were also considered.

Pre-Blood-Donation Screening of Volunteer Prisoners for Hepatitis B and C in Prisons of the Punjab, Pakistan.

Objectives: To identify the potential benefits of pre-donation screening of blood. Study design: Retrospective. Place and Duration: Prisons in the Punjab province. From January 2011 t0 September 2013. Background: Prisoners, as a high risk group, are not recommended for blood donations. In Pakistan, however, prisoners are legally allowed to donate blood and get thirty days remission. Methodology: Volunteer prisoners, after examination and verification by a physician for their physical fitness, were tested for Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) by Rapid Test Kit before bleeding. Data was analyzed by Epi-Info. Results: A total of 5894 male volunteer prisoner donors were screened and 1038 (17.6%) were rejected because of hepatitis infection. The mean age was 28 years (range; 17 - 70 years). Of 5894 prisoners, 857 (14.5%) were HCV positive and 222 (3.8%) were HBV positive. Co-infection of HCV and HBV was present among 41 (0.7%). Hepatitis infection, among convicted- prisoner blood donor, is significantly associated with higher seroprevalence for HCV (OR 1.35, 95% C.I. 1.17-1.57) while under-trial- prisoner is significantly associated with higher seroprevalence for HBV (OR 1.40, 95% C.I. 1.06-1.85). Conclusion: Hepatitis B and C viruses were responsible for almost 18% prisoner blood donor rejection. Pre-donation screening of blood donors is an effective intervention to improve the safety and limit the cost of blood. Treatment of identified infected prisoners may contribute to public health. In the international scenario this study findings necessitate the amendments in the relevant prison rules.

Evaluation of Point-of-Care Testing Devices for Pre-donation Alanine Aminotransferase Test / 대한수혈학회지

BACKGROUND: In Korea, since 1990, in an effort to reduce the transmission of non-A, non-B hepatitis, all blood donations with alanine aminotransferase (ALT) levels above 65 IU/L are discarded. In 2012, 64.8% of the disposed blood units at the Korean Red Cross blood centers were due to high ALT levels. Pre-donation ALT testing might prevent unnecessary blood donation and save related expenses. We evaluated performance of point-of-care test (POCT) devices for pre-donation ALT screening. METHODS: ALT levels by four ALT POCT devices (Mission C100, Acon; Reflotron Plus, Roche; Labgeo PT10, Samsung; and FDC NX500, Fujifilm) were compared with venous blood results using laboratory chemistry analyzers (AU series, Beckman Coulter Inc.). Intraclass correlation coefficients (ICCs), sensitivity (ability to detect ALT > or =65 IU/L), and specificity (ability to detect <65 IU/L) for each method were calculated. RESULTS: Compared with the laboratory analyzers, the ICCs of ALT measurements by Mission C-100, Reflotron Plus, Labgeo PT10, and FDC NX500 were 0.96 (95% confidence interval (CI): 0.95~0.97), 0.99 (95% CI: 0.99~0.99), 0.98 (95% CI: 0.98~0.98), and 0.94 (95% CI: 0.91~0.96), respectively. The sensitivity was 80.95% for Mission C-100, 83.33% for Reflotron Plus, 78.57% for Labgeo PT10, and 97.62% for FDC NX500. The specificity was 99.13% for Mission C-100, 100.00% for Reflotron Plus, 99.78% for Labgeo PT10, and 98.26% for FDC NX500. CONCLUSION: The ALT POCT devices showed almost perfect agreement with the laboratory analyzers and could be useful for pre-donation ALT screening. However, before implementing ALT POCT devices, cost-effectiveness analyses should be performed.