RESUMO
Alzheimer∗ s disease (AD) is a typical central nervous degenerative disease characterized by progressive cognitive impairment and behavioral damage, which is associated with the major pathological manifestations of extracellular amyloid deposition, intracellular neurofibrillary tangles, and neuron loss. Mild cognitive impairment ( MCI) is a kind of cognitive impairment status between normal cognition and AD, which is linked with a high risk of converting into AD. Previous studies mostly establish the animal models with clinical AD characteristics for mechanism research, drug screening, and new drug development. In recent years, researchers have attempted to establish animal models with clinical MCI characteristics, trying to intervene ear-ly at MCI stage to effectively prevent the occurrence of AD. There are many types of AD experimental animal models, and the MCI model should be distinguished from the AD model. Based on the systematic introduction of the characteristics of AD and MCI, this study aims to preliminarily evaluate the commonly used AD and MCI experimental animal models, providing sug-gestions for the research of AD and MCI.
RESUMO
The integrated curriculums of basic medicine in Shanxi Medical University are as follows: nine basic medical courses were integrated into 10 medical modules, with additional training including PBL and TBL case discussion, clinical clerkship, flipped classroom and other non-integrated subjects etc. In order to assess the interest of students for integrated curriculum, their intrinsic motivation, as well as their comprehension and application of medical knowledge, we gave anonymous questionnaire to 149 students, 16 teachers in basic medicine, and 10 teachers in clinical medicine. Results showed that more than 90% students were willing to take the integrated curriculum and participate in PBL and TBL case discussion, and students who were unwilling to take the curriculum were less than 10%, they thought that the knowledge of new curriculum system was incoherent. The proportion of students from higher grade who were unwilling to participate in the flipped classroom was increased from 6.7% to 95.0%. Most of the teachers both in basic and clinic medicine believed that new curriculum system was helpful for students to comprehend basic medical knowledge and strengthen their discriminating ability, but did not function in improving students' practical ability. In the further reform on teaching, details like the coherence of knowledge and the content selected when self-studying should be improved.
RESUMO
The integrated curriculums of basic medicine in Shanxi Medical University are as follows:nine basic medical courses were integrated into 10 medical modules,with additional training including PBL and TBL case discussion,clinical clerkship,flipped classroom and other non-integrated subjects etc.In order to assess the interest of students for integrated curriculum,their intrinsic motivation,as well as their comprehension and application of medical knowledge,we gave anonymous questionnaire to 149 students,16 teachers in basic medicine,and 10 teachers in clinical medicine.Results showed that more than 90％ students were willing to take the integrated curriculum and participate in PBL and TBL case discussion,and students who were unwilling to take the curriculum were less than 10％,they thought that the knowledge of new curriculum system was incoherent.The proportion of students from higher grade who were unwilling to participate in the flipped classroom was increased from 6.7％ to 95.0％.Most of the teachers both in basic and clinic medicine believed that new curriculum system was helpful for students to comprehend basic medical knowledge and strengthen their discriminating ability,but did not function in improving students' practical ability.In the further reform on teaching,details like the coherence of knowledge and the content selected when self-studying should be improved.