Analysis of pregnancy outcomes after transplantation of frozen-thawed embryo transfer in PCOS patients / 安徽医科大学学报

Objective @#To investigate the factors influencing the pregnancy outcomes during frozen-thawed embryo transfer (FET) cycles in patients with polycystic ovary syndrome (PCOS) . @*Methods @#A retrospective analysis was conducted on patients ’data from 882 FET cycles . According to the pregnancy outcome , the patients were divided into non-implantation group (Group A) , abortion group ( Group B1) and live birth group ( Group B2) . Clinical data and laboratory parameters were compared among the three groups , and ordered Logistic regression analysis was used to study the factors influencing pregnancy outcomes after FET. Patients were also divided into four groups (C1-C4) based on the number of high-quality embryos obtained (0 - 3 , 4 - 6 , 7 - 10 , ≥11) , and their clinical data and laboratory parameters were compared .@*Results @#The clinical pregnancy rate , live birth rate , and miscarriage rate in the 882 treatment cycles were 71 . 09% (627/882) , 61 . 68% (544/882) , and 13 . 24% (83/627) ,respectively. Single-factor analysis showed significant differences in body mass index (BMI) , infertility type , human chorionic gonadotropin (hCG) day estradiol ( E2 ) level , number of retrieved oocytes , and number of high-quality embryos among Groups A , B1 , and B2 (P < 0. 05) . Further multiple Logistic regression analysis revealed that BMI(OR = 1 . 046 , 95% CI:1 . 001 - 1 . 093 , P = 0. 044) and a history of previous pregnancy(OR = 1 . 417 , 95% CI:1 . 030 - 1 . 950 , P = 0. 032) were independent risk factors for successful FET in PCOS patients , while an increased number of high-quality embryos was an independent protective factor for successful pregnancy. Based on the results of Group B2 , compared to Group A , OR = 0. 920 , 95% CI:0. 880 - 0. 962 , P = 0. 000;compared to Group B1 , OR = 0. 923 , 95% CI:0. 862 - 0. 988 , P = 0. 022 . Compared with the other three groups( C1-C3) , the total amount of gonadotropin (Gn) in the C4 group was the lowest and the number of oocytes obtained was the highest (P < 0. 05) . Multiple comparisons showed that Group C4 had lower BMI , follicle-stimulating hormone (FSH) , very low-density lipoprotein ( vLDL) levels , a higher luteinizing hormone and follicle-stimulating hormone ( LH/FSH) ratio compared to Group C1 (P < 0. 05) . Group C4 had lower fasting insulin (FINS) and homeostasis model assessment of insulin resistance ( HOMA-IR) levels compared to Group C3 , and higher high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A1 (Apo A1) levels compared to Groups C2 and C3 (P < 0. 05) . @*Conclusion@#BMI , the history of previous pregnancy and the number of high-quality embryos were both independent factors for predicting pregnancy outcomes in PCOS patients undergoing FET cycles . Patients with a higher number of high-quality embryos have a higher clinical pregnancy rate during FET cycles .

Misoprostol and mid trimester termination of pregnancy in patients with two previous scars and more at Elwiya Maternity Teaching Hospital / Misoprostol e interrupção da gravidez no meio do trimestre em pacientes com duas cicatrizes anteriores e mais no Elwiya Maternity Teaching Hospital

Abstract Objectives: to determine efficiency and safety of three misoprostol regimens for 2nd trimester pregnancy termination in individuals with two or more cesarean section scars. Methods: a cross-sectional study included 100 pregnant ladies at 13th-26th weeks gestation with previous two cesarean sections (CSs) who were scheduled for pregnancy termination using misoprostol. Patients were conveniently assigned to 100µg/3h, 200µg/3h or 400 µg/3h regimens. Primary outcome was time to abortion, secondary outcomes were side effect and complications. Results: a significant association was found between number previous CSs and longer time to abortion (p=0.01). A highly significant association was identified between earlier gestational age and longer time to abortion (p<0.001). Lower side effects and complications were associated with 200 µg misoprostol every 3 hours of (p<0.001). Incomplete abortion was the most frequent recorded complication for the successive doses of misoprostol. Conclusions: misoprostol is an effective drug at low doses for pregnancy termination in women with prior two or more caesarean sections. However, its safety needs monitoring of the patient in the hospital to decrease morbidity and mortality behind its use.

Resumo Objetivos: determinar a eficiência e segurança de três regimes de misoprostol para interrupção da gravidez no segundo trimestre em indivíduos com duas ou mais cicatrizes de cesariana. Métodos: um estudo transversal incluiu 100 gestantes entre 13ª e 26ª semanas de gestação com duas cesarianas (CEs) anteriores que foram agendadas para interrupção da gravidez com uso de misoprostol. Os pacientes foram convenientemente designados para regimes de 100 µg/3 horas, 200 µg/3 horas ou 400 µg/3 horas. O desfecho primário foi o tempo para o aborto, os desfechos secundários foram efeitos colaterais e complicações. Resultados: foi encontrada associação significativa entre o número de cesáreas anteriores e o maior tempo até o aborto (p=0,01). Foi identificada associação altamente significativa entre idade gestacional mais precoce e maior tempo para abortar (p<0,001). Menores efeitos colaterais e complicações foram associados com 200 µg de misoprostol a cada 3 horas (p<0,001). O aborto incompleto foi a complicação mais frequente registrada para as doses sucessivas de misoprostol. Conclusões: o misoprostol é um medicamento eficaz em doses baixas para interrupção da gravidez em mulheres com duas ou mais cesarianas anteriores. Porém, sua segurança necessita de monitoramento do paciente no hospital para diminuir a morbimortalidade por trás de seu uso.

Prior statin use and the incidence of in-hospital arrhythmia in acute coronary syndrome: A systematic review and meta-analysis

Background: The benefit of prior statin use to reduce the incidence of arrhythmia in acute coronary syndrome (ACS) is still a matter of debate. Statins have multiple pleiotropic effects, which may reduce the incidence of in-hospital arrhythmia. A systematic review and meta-analysis were performed to evaluate prior statin use and the incidence of in-hospital arrhythmia in ACS. Methods: This systematic review was conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). We performed a literature search through Pubmed, Proquest, EBSCOhost, and Clinicaltrial.gov. A random-effect model was used due to moderate heterogeneity. Quality assessment was performed using Newcastle Ottawa Scale. Sensitivity analysis was performed by using leave one or two out method. PROSPERO registration number: CRD42022336402. Results: Nine eligible studies consisting of 86,795 patients were included. A total of 22,130 (25.5%) patients were in statin use before the index ACS event. The prevalence of old myocardial infarction, heart failure, hypertension, diabetes mellitus, and chronic renal failure and concomitant treatment with aspirin, clopidogrel, and beta blocker was higher in the prior statin group compared to no previous statin. Overall, prior statin use was associated with a significantly lower incidence of in-hospital arrhythmia during ACS compared to no previous statin (OR 0.60; 95% CI 0.49e0.72; P < 0.00001; I2 ¼ 54%, Pheterogeneity ¼ 0.03). In subgroup analysis, previous statin use reduced the incidence of atrial fibrillation or atrial flutter (OR 0.64; 95% CI 0.43e0.95; P ¼ 0.03; I2 ¼ 73%, P-heterogeneity ¼ 0.01) and ventricular tachycardia or ventricular fibrillation (OR 0.57; 95% CI 0.49e0.65; P < 0.00001; I2 ¼ 8%, Pheterogeneity ¼ 0.35). Conclusions: Based on aggregate patient data, prior statin use may reduce the incidence of in-hospital arrhythmia during ACS, particularly atrial fibrillation or atrial flutter and ventricular tachycardia or ventricular fibrillation.

Value and influencing factors of preoperative MRI evaluation for previous cesarean scar defect associated abnormal uterine bleeding in patients undergoing laparoscopic surgery / 中南大学学报(医学版)

Objective:As the cesarean section rate increases year by year,the treatment of previous cesarean scar defects(PCSD)poses a significant challenge.This study aims to evaluate the clinical value of preoperative magnetic resonance imaging(MRI)technology and analyze relevant influencing factors for patients with abnormal uterine bleeding(AUB)associated with cesarean scar defects who underwent laparoscopic surgery.Methods:A retrospective cohort analysis was performed on women who underwent laparoscopic surgery for PCSD-related AUB at the Department of Gynecology,the Third Xiangya Hospital of Central South University from 2018 to 2022.A total of 57 patients who underwent laparoscopic surgery for the treatment of AUB associated with PCSD were divided into 2 groups based on their postoperative clinical cure status:The clinically-cured group(n=28,49.1%)and the non-clinically-cured group(n=29,50.9%).After a postoperative follow-up period of 3 months for all participants,logistic regression analysis was conducted to explore the correlation between the clinical cure rate of AUB associated with cesarean scar defects treated by laparoscopic surgery and various factors.These factors included patient age,clinical symptoms,obstetric history,history of cesarean section,basic clinical information,preoperative MRI parameters,and postoperative menstrual conditions.Results:There were no significant differences in many aspects,including the patient's age at the time of previous cesarean section,number of pregnancy,time since the previous cesarean section,the uterus position assessed by preoperative T2 signal MRI,defect length,defect width,residual muscle layer thickness,adjacent uterine muscle layer thickness,and distance from the defect to the external cervical os between the 2 groups(all P>0.05).However,the time of onset of AUB symptoms(P=0.036,OR=1.019,95%CI 1.002 to 1.038)and the depth of the defect on the preoperative MRI(P=0.010,OR=5.793,95%CI 1.635 to 25.210)were identified as risk factors affecting the clinical cure rate.Conclusion:The time of onset of AUB symptoms and the depth of the defect on preoperative MRI are risk factors that influence the clinical cure rate of laparoscopic surgery for the treatment of AUB associated with PCSD,which could be helpful for evaluating the prognosis of disease.

Anomalías de inserción placentaria: diagnóstico y tratamiento oportuno / Placental insertion anomalies: timely diagnosis and treatment

Paciente de 34 años, gestante de 34 semanas. Doble cesáreada anterior con estudio ecográfico previo con informe de signos indirectos de ascetismo placentario, sin estudio de Resonancia Magnética Nuclear. Se realizó Operación Cesárea abdominal corporal, se dio nacimiento a recién nacido vivo. Se realizó instilación de 2 ampollas de 2 ml. de polidocanol al 3 % con sonda K33 en cordón umbilical para disminución del riesgo de sangrado, ligadura del mismo, introducción de cordón en cavidad uterina y cierre de Histerorrafia + Histerectomía subtotal El diagnóstico oportuno por medio de estudios de imagen, actuación médica criteriosa y el seguimiento de los protocolos establecidos nos llevara a la excelencia en la resolución de dichos casos.

34-year-old patient, 34 weeks pregnant. Previous double caesarean section with a previous ultrasound study with a report of indirect signs of placental asceticism, without a Nuclear Magnetic Resonance study. An abdominal cesarean section was performed, giving birth to a live newborn. Instillation of 2 ampoules of 2 ml was performed. of 3% polidocanol with a K33 probe in the umbilical cord to reduce the risk of bleeding, ligation of the cord, introduction of the cord into the uterine cavity and closure of hysterorrhaphy + subtotal hysterectomy Timely diagnosis through imaging studies, judicious medical action and following established protocols will lead us to excellence in the resolution of these cases.

Menor opción de parto en cesáreas repetidas: estudio de caracterización / Minor option for vaginal delivery in repeat cesarean sections: characterization study

Resumen OBJETIVO: Describir las características de las pacientes con cesárea por indicación de cesárea anterior. MATERIALES Y METODOS: Estudio cuantitativo, descriptivo, observacional y retrospectivo llevado a cabo en el Hospital Regional de Medicina Tropical Julio César Demarini Caro, Chanchamayo, Junín, Perú, entre enero de 2020 y junio de 2021. La información se recopiló de las historias clínicas completas y legibles de los sujetos de investigación y se reunió en una base de datos de Excel y se procesó en el programa SPSS versión 25. Se aplicaron estadística descriptiva, medidas de tendencia central y de frecuencias simples. RESULTADOS: La muestra estudiada fue de 200 mujeres que finalizaron el último embarazo por cesárea; la indicación fue, precisamente, cesárea previa. El 40% no tuvo otra indicación secundaria para la cesárea y 19% tuvo como indicación adicional el sufrimiento fetal agudo. Características obstétricas: multíparas (83.5%), con periodo intergenésico adecuado (62.5%), con atención prenatal adecuada (69%), y con pelvis ginecoide (84.5%). Complicaciones de las madres: anemia moderada y severa (64.5%), rotura uterina (10.5%) y atonía uterina (5%). Complicaciones perinatales: Apgar menor a 7 (15%), asfixia neonatal (11%) y síndrome de insuficiencia respiratoria (9%). CONCLUSIONES: Las indicaciones de las cesáreas previas fueron: sufrimiento fetal agudo, desproporción cefalopélvica, trastornos funiculares, trastornos hipertensivos, oligohidramnios severo y distocias de presentación. Las principales complicaciones materno-perinatales fueron: anemia moderada y severa, rotura uterina, atonía uterina, Apgar del recién nacido menor o igual a 7, asfixia neonatal, síndrome de insuficiencia respiratoria y recién nacido prematuro.

Abstract OBJECTIVE: To determine the main characteristics of patients with previous cesarean section. MATERIALS AND METHODS: Quantitative, descriptive, observational and retrospective study carried out at the Regional Hospital of Tropical Medicine Julio César Demarini Caro, Chanchamayo, Junín, Peru, between January 2020 and June 2021. The information was collected from the complete and legible medical records of the research subjects and was collected in an Excel database and processed in SPSS version 25. Descriptive statistics, measures of central tendency and simple frequencies were applied. RESULTS: The sample studied consisted of 200 women whose last gestation was terminated by cesarean section; the indication was, precisely, previous cesarean section. Forty percent had no other secondary indication for cesarean section and 19% had acute fetal distress as an additional indication. Obstetric characteristics: multiparous (83.5%), with adequate inter-gestational period (62.5%), with adequate prenatal care (69%), and with gynecoid pelvis (84.5%). Maternal complications: moderate and severe anemia (64.5%), uterine rupture (10.5%) and uterine atony (5%). Perinatal complications: Apgar less than 7 (15%), neonatal asphyxia (11%) and respiratory failure syndrome (9%). CONCLUSIONS: Indications for previous cesarean sections were acute fetal distress, cephalopelvic disproportion, funicular disorders, hypertensive disorders, severe oligohydramnios and presentation dystocias. The main maternal and perinatal complications were moderate and severe anemia, uterine rupture, uterine atony, newborn Apgar less than 7, neonatal asphyxia, respiratory distress syndrome and premature newborn.

A propósito de un caso: presentación atípica de rotura uterina / A case report: unusual presentation of uterine rupture

RESUMEN La rotura del útero gestante se define como una solución de continuidad patológica de la pared uterina, situada con mayor frecuencia en el segmento inferior. La rotura de un útero intacto es muy rara, su incidencia está estimada entre 1/5700 y 1/20000 embarazos. Su prevalencia ha aumentado dado el incremento de parto vaginal con cesárea anterior. Actualmente oscila entre el 0.3 y el 1 %, siendo mayor en mujeres en las que tiene lugar un intento de parto vaginal tras cesárea (0,78%) que en aquellas en las que se lleva a cabo una cesárea electiva (0,22%). En cuanto a su diagnóstico, suele ser precoz, dada la clínica de gravedad con la que debutan. En este caso se presenta una evolución atípica de rotura uterina, donde la paciente se mantiene asintomática hasta que acude a urgencias cinco días después del parto con fiebre y dolor abdominal; gracias a la ecografía abdominal y trans-vaginal se pudo establecer rápidamente el diagnóstico y así proceder a su inmediata reparación quirúrgica.

ABSTRACT Rupture of the pregnant uterus is defined as a solution of pathological continuity of the uterine wall, most often located in the lower segment. The rupture of an intact uterus is very rare, its incidence is estimated between 1/5700 and 1/20000 pregnancies. Its prevalence has increased given the increase in vaginal delivery with previous caesarean section. Currently, it ranges between 0.3 and 1%, being higher in women with a vaginal delivery after caesarean section (0.78%) than in those who undergo an elective caesarean section (0.22%). Their diagnosis is usually early given by the severity of the debut. In this case, there is an atypical evolution of uterine rupture where the patient remains asymptomatic until she goes to the emergency room five days after delivery with fever and abdominal pain; Because of the abdominal and transvaginal ultrasound, the diagnosis could be quickly established and thus proceed to immediate surgical repair.

Vitrectomy combined with air tamponade in the management of rhegmatogenous retinal detachment following previous vitreoretinal surgery / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To observe the efficacy and safety of pars plana vitrectomy(PPV)combined with air tamponade in the treatment of rhegmatogenous retinal detachment(RRD), which caused by superior break(s)following previous vitreoretinal surgery.<p>METHODS: Retrospective analysis of the inpatients in our hospital from November 2017 to October 2019. Patients with RRD caused by superior break(s)who had underwent previous vitreoretinal surgeries and the proliferative vitreoretinopathy less than PVR-C1 were enrolled. For treatment, patients underwent PPV combined with air tamponade. During the operation, the residual vitreous cortex was fully removed, and the subretinal fluid was aspirated from retinal break(s)as much as possible. Make sure the subretinal fluid around the hole was fully drained. Then firmly laser spots were accomplished to seal the retinal break(s). Finally, filtered air was left in the vitreous cavity as tamponade agent. The patients were informed to keep a prone position for 24h postoperation. The primary outcomes were primary and final success rates, best corrected visual acuity(BCVA), and the secondary outcomes were rate of postoperative cataract surgery and high intraocular pressure.<p>RESULTS: Totally 31 patients(31 eyes)with follow-up time more than 6mo were included. The range of retinal detachment was 6.7±3.8h, and the number of retinal breaks was 1.2±0.7. There are 23 eyes(74%)with macular detachment and 18 eyes(58%)with intraocular lens. 6 eyes(19%)were treated with phacoemulsification and intraocular lens implantation together. The rate of primary retinal reattachment in enrolled patients was 87%(27/31), and the final reattachment rate was 100%(31/31). At the 6mo of postoperatively, the BCVA(LogMAR)increased from 2.17±1.27 to 0.53±0.25(<i>P</i><0.001). Furthermore, 5 eyes(16%)developed transient ocular hypertension.<p>CONCLUSION: PPV with air tamponade can achieve a high success reattachment rate in the management of RRD following previous vitreoretinal surgery. It has the advantages of short postoperative prone time and fewer complications.

Significance and progress in laboratory diagnosis of Mycoplasma pneumoniae pneumonia / 中华实用儿科临床杂志

Mycoplasma pneumoniae pneumonia (MPP) is a clinical common respiratory tract infectious di-sease.In recent years, the number of children with severe and refractory MPP has increased significantly.Clinical symptoms of MPP are usually atypical, and some MPP cases are accompanied with extrapulmonary complications.In addition, imaging features of MPP also lack specificity.The diagnosis of MPP, as a result, often relies on laboratory examinations.The present study demonstrated the clinical significance in laboratory diagnosis of Mycoplasma pneumoniae (MP) infection, and the method to distinguish present infection, previous infection or carriers in healthy children′s respiratory tract.Moreover, the method to determine macrolide-resistant MP was also described in this study.This study aims to improve the understanding, diagnosis and treatment of MP infection.

Taxa de parto normal versus cesárea em gestantes com uma cesárea anterior e fatores associados / Normal birth rate versus cesarean in pregnant women and associated factors

Objetivo: Calcular taxa de parto vaginal e cesárea em pacientes com uma cesárea anterior e gestação a termo, bem como fatores associados à recorrência de cesaria- na. Métodos: Estudo caso-controle, por meio de dados de prontuário de gestantes a termo com uma cesárea prévia admitidas para parto na Maternidade Darcy Vargas do município de Joinville (SC), em 2019. Resultados: Foram analisadas 788 pacientes, das quais 331 (42,00%) tiveram parto normal (PN) e 457 (58,00%), cesárea (CS). O grupo PN foi composto por mulheres mais velhas (29; 28) e com mais gestações que o grupo CS, possuindo pelo menos um parto normal prévio (171; 57; p < 0,001). Como fator de risco para recorrência de cesárea, destacou-se a presença de colo desfavorável no momento do parto (47; 356; p < 0,001). Internação por trabalho de parto (284; 92; p < 0,001) e ruptura prematura de membranas (RUPREME) (33; 79; p = 0,030) estão entre os fatores de proteção para ocorrência de uma nova cesariana. Conclusão: A taxa de parto vaginal pós-cesariana (VBAC) foi de 42% e a de parto cesáreo foi de 58%, condi- zente com valores de referência mundiais. O fato de ter um ou mais partos normais anteriores e internar-se em trabalho de parto ou com RUPREME foi fator protetor contra a repetição da cesárea, enquanto o colo desfavorável no momento da inter- nação foi fator de risco. Há grande divergência na literatura, sendo necessários mais estudos para elaborar estratégias que auxiliem profissionais e pacientes a decidirem pela melhor via de parto após cesariana anterior.(AU)

Objective: To calculate the rate of vaginal and cesarean delivery in patients with pre- vious cesarean section and pregnancy to term, as well as factors associated with recur- rent abdominal delivery. Methods: Case-control study, by medical records of pregnant women to term with a previous cesarean section admitted for delivery at Maternity Dar- cy Vargas in the city of Joinville (SC) in 2019. Results: 788 patients, of which 331 (42,00%) had a normal delivery (PN) and 457 (58,00%) cesarean section (CS). The PN group was composed of older women (29;28), and who had more pregnancies than the CS group, having at least 1 previous vaginal birth (171; 57; p < 0,001). As a risk factor for cesarean recurrence, the presence of an unfavorable cervix at the time of delivery was highlighted (47; 356; p < 0,001). Hospitalization for labor (284; 92; p < 0,001) and premature rupture of membranes (33; 79; p = 0,030) are among the protective factors for the occurrence of a new cesarean section. Conclusion: The post-cesarean vaginal birth (VBAC) rate was 42% and the cesarean delivery rate was 58%, consistent with world reference values. The fact of having one or more previous normal bir- ths, hospitalization in labor or with premature rupture of fetal membranes were protective factors against the repetition of cesarean section, while the unfavorable cervix at the time of hospitalization was a risk factor. There is divergence in litera- ture, therefore more studies are needed to develop strategies that help professionals and patients to decide on the best way of delivery after a previous cesarean section.(AU)

Risk factor and perinatal outcome of preterm delivery in a tertiary care centre in rural Haryana

Background: Aim of the study was to identify risk factors and to assess neonatal mortality and morbidity associated with preterm delivery in patient attending a tertiary care centre in rural Haryana.Methods: This retrospective cohort study was conducted in Shree Guru Gobind Singh Tricentenary Medical College, over a period of one year (January to December). All pre-term deliveries were included in the study. They were followed up from admission till delivery and till discharge from hospital. Various, parameters like maternal age, associated medical disorder, obstetric complications, gestational age, neonatal mortality, need of neonatal intensive care and condition of baby at discharge were analyzed.Results: In the present study, incidence of preterm deliveries was 16.1%. The most common risk factor found to be history of previous abortion (23.6%), preterm premature rupture of membrane (17.1%), Intra-uterine growth restriction (IUGR) with oligohydramnios (10.5%), hypertensive disorder during pregnancy (5.9%), and antepartum hemorrhage (4.6%). But majority of the patient (56.5%) no cause could be identify. Out of total 160 preterm births 3 were still born and 157 live preterm births, and out of which total Neonatal intensive care (NICU) admission were 60. Mortality rate was 100% in neonate weighing less than 1000 gm and 18% in babies weighing less than 2000 gm.Conclusions: The commonest risk factor for preterm delivery is previous history of abortion and adverse perinatal outcome is inversely proportionate to the period of gestation at the time of delivery. All efforts should be made to prolong the pregnancy beyond 34 weeks by identifying and actively managing the risk factors for better neonatal outcome.

Comparison of the efficacy, safety, acceptability and fetomaternal outcomes of combination of mifepristone and foley’s catheter with foley’s catheter alone in induction of labour in term pregnancies with previous lower segment caesarean section

Background: Objective of the study was to compare the efficacy, safety, acceptability, fetomaternal outcomes of combination of mifepristone and Foley’s catheter with Foley’s catheter alone in induction of labor in term pregnancies with previous Lower segment caesarean section (LSCS).Methods: This was a prospective study of 36 women induced with mifepristone and foley’s catheter and 36 women induced with foley’s catheter alone at 37 weeks to 41+6 weeks with previous LSCS.Results: Mean bishop score on admission in combined group (2.44) was comparable with that of foley’s alone group (2.91, p=0.888). Mean Bishop score (BS) after foley’s expulsion in group A and group B was 7.46 and 6.33 respectively, which was statistically significant (p<0.001). In group A 69.5% of women delivered vaginally compared to 52.2% in group B which was comparable (p=0.230). Mean induction to delivery interval was significantly short in combination group (15.5±1.3 hours versus 20.8±1.07 hours, p=0.003). 50% women in group A required oxytocin for induction/ augmentation of labour as compared to 77.8% in group B (p=0.02). Failed induction was statistically higher in group B (p<0.05). No difference was found with regards scar dehiscence, scar rupture, Postpartum hemorrhage (PPH), wound infection, puerperal pyrexia, Meconium stained liquor (MSL), fetal distress, mean birth weight, 1 and 5 minutes Appearance, pulse, grimace, activity, and respiration (APGAR) score, neonatal outcome, hospital stay.Conclusions: Priming with mifepristone before insertion of foley’s catheter results in significant change in BS signifying that combination promotes early cervical ripening as compared to foley’s catheter alone. Mifepristone plays significant role in cervical ripening, reduces induction to delivery interval, oxytocin requirement and failed induction.

Outcome of pregnancy in previous caesarean section: an observational study

Background: Presently, good obstetrics means an uncomplicated antenatal period, labour and puerperium for the mother and birth of a healthy body. Post caesarean section pregnancy has now become one of the most common high-risk cases tackled at any hospital. In this paper an attempt has been made to assess the outcomes of pregnancy in previous caesarean section.Methods: This study was conducted among patients in the department of gynecology and obstetrics at Al-Ameen Hospital from June 2016 to December 2018. For that purpose, a sample size of 100 was considered. Data were analyzed using SPSS software v. 23.0. and Microsoft office 2007.Results: The incidence of caesarean section was 10.25%. Anaemia, pregnancy-induced hypertension and diabetes mellitus found in this study is more coincidental. Placenta previa cases were also present. Cephalopelvic disproportion was the commonest indication of the previous section in this study. 20% of the cases have had their previous section due to cephalopelvic disproportion. 18% of the cases had delivered vaginally, 15 cases were delivered by forceps (72.2%) and 3 cases were delivered normally (27.8%). Maternal morbidity was found to be low and there was no maternal death.Conclusions: The patient whose primary section was done due to cephalopelvic disproportion should be assessed thoroughly in her current pregnancy before placing her to elective repeat section. As there is always the possibility of scar rupture in a case of post caesarean section pregnancy one must think twice before doing the primary section. More research is required to evaluate optimum time of management.

Study of fetomaternal outcome in cases of placenta previa at tertiary care hospital

Background: Placenta previa is defined as placenta implanted partially or completely in the lower uterine segment. It contributes upto 30% of the cases the antepartum hemorrhage. This catastrophic complication not only poses a risk to the fetus but also endangers the mother’s life. The objective of the study was to determine the incidence and risk factors, obstetric management, maternal mortality and morbidity and perinatal outcome in women presenting with placenta previa.Methods: It is the prospective study of 50 cases carried out to study the maternal and perinatal outcome in cases of placenta previa in tertiary care hospital. This study included antenatal patient diagnosed as placenta previa by ultrasound >28 weeks to full term pregnancy. This data was compiled and analyzed for maternal and neonatal outcome.Results: In the present study, the incidence of placenta previa is 0.8% among which 42% of cases having age group of 25-29 years and 72% cases are multigravida. In this study 60% cases have major degree of placenta previa and 66% cases have previous history of caesarean section. Out of total cases 96% cases delivered by caesarean section and 4% had Normal delivery. NICU admission in the study is 28 babies i.e. 56%. There is no maternal mortality seen in the present study.Conclusions: Risk factors that increase the cases of placenta previa are multiparity, previous caesarean section, previous abortion. Placenta previa is major risk factor for adverse maternal and perinatal outcome. Good antenatal care, availability of emergency obstetrics services with senior obstetricians, blood bank facility, ICU care and NICU services can improve maternal and neonatal outcome in high risk cases.

Changing trends of indication of caesarean section

Background: Percentage of previous C-section undergoing repeat section is close to 90%-92%, morbidity associated with repeat surgery is bringing an altogether new set of challenges for the upcoming future obstetricians. Object of this study is to highlight high incidence of repeat section required and also growing new indications of C-section due to advanced availability of investigative tools.Methods: Retrospective study of 500 patients who underwent C-section and their indications from April 2019 to July 2019 in Govt Doon Medical college, Dehra Dun.Results: Out of total 500 C-sections carried from April 2019 to July 2019, patients with previous section were found to undergo a repeat C-section in 95% of the cases. Another common indication being oligohydramnios followed by cephalopelvic disproportion and failed induction.Conclusions: After assessing the results it is hereby concluded that the commonest indication of C-section in present time is having a previous C-section, which alarms us to take careful judicious decision in performing primi C-sections in order to prevent patients into entering a vicious cycle of repeat surgeries.

A study of high-risk factors in ante-natal women at a tertiary care centre

Background: High-risk pregnancy refers to any condition in pregnancy that increases risk for morbidity or mortality in mother, fetus and neonate. Globally, nearly 5,29,000 women die due to pregnancy related complications. In India, 20-30% of the pregnant patients contribute to high risk group. This study was conducted to determine different high-risk factors prevalent in antenatal women in Haryana. Objective of this study was to find out prevalence of different high-risk factors in antenatal women.Methods: Data of all antenatal high-risk patients attending OPD during one year was taken from hospital record registers. Maternal characteristics such as age, gravida/parity, gestational age, and gestational age at the time of first visit were noted. High risk factors identified were noted.Results: The records of total 10073 antenatal women were analyzed, 1283 were included in the high-risk group. Most prevalent high-risk factors found were previous cesarean section (31.04%), anaemia (31.02%), malpresentation (12.93%) and thyroid disorders (13.09%).Conclusions: Antenatal surveillance for the high-risk factors complicating pregnancy may prevent or treat most of the complications. Authors should develop strategies for early screening of high-risk pregnancy cases to prevent maternal and perinatal mortality and to improve the maternal and perinatal outcome.

A study on pattern of placentation in post caesarean pregnancy

Background: It appears that the rate of caesarean delivery has been increasing over the past two decades. Various western studies have shown that with previous caesarean section, increased risk of placenta previa, adherent placenta, and greater incidence of antepartum haemorrhage. Nonetheless, the extent to which previous caesarean delivery predisposes women to the development of placenta previa is unclear from earlier studies. Also, there are not many Indian studies regarding the association of placenta previa and previous caesarean section. This study aims to find the association between prior caesarean delivery and subsequent development of placenta previa and adherent placenta.Methods: A descriptive study was conducted on 600 antenatal women with post cesarean pregnancy in a tertiary care centre. Similar number of women with previous normal delivery was included in comparison group and placental location was studied. Those patients with previous caesarean were further divided into those with placenta previa and without previa to study the determinants of previa in those with previous caesarean section.Results: Placenta previa was found in 2.8% of the study group compared to 1.2% of comparison group. Adherent placenta was found only in post caesarean group. In the post caesarean group, the incidence of anterior previa was 41.2% compared to posterior previa (29.3%). In those with post cesarean pregnancy, determinants of placenta previa found were multiparity (35.3%), previous history of abortions (35%), multiple previous caesarean sections (29.4%), interpregnancy interval <2 years (35.29%).Conclusions: In post cesarean pregnancy, the risk of placenta previa is 2 times compared to those with a previous normal delivery. Anterior previa occurred with sufficient frequency in post-caesarean pregnancy to warrant ultrasonic placentography prior to surgical entry into lower segment. When the combination of previous caesarean and placenta previa occurs the risk of adherent placenta is 17.6%.

Comparative study of mifepristone versus balloon catheter for cervical ripening and induction of labour in previous caesarean section

Background: The objective of this present study was to compare the efficacy of oral mifepristone and balloon catheter for cervical ripening and induction of labour in women with previous caesarean section.Methods: This prospective study was conducted on 130 pregnant women with previous 1 caesarean section and term singleton pregnancy admitted for induction of labour. Sixty-five patients were induced with oral mifepristone (Group 1) and in another 65 transcervical balloon catheter (Group 2) was inserted for induction of labour. Both groups were than compared with respect to change in bishop score, induction to active phase interval, induction to delivery interval, dose of oxytocin in milliunits, mode of delivery, maternal complication and fetal outcomes.Results: Change in bishop score after induction was more in mifepristone group than balloon catheter group (p=0.002). Favorable bishop score was more in Group 1 (83.07%) than Group 2 (66%), p=0.05. There was significant difference in mode of delivery between two groups, 61.53% in Group 1, and 32.3% in Group 2 delivered vaginally (p<0.001).Conclusions: Present study showed that mifepristone is an alternative to balloon catheter for induction of labour in women with previous one caesarean section with poor bishop score.

Study of caesarean section at tertiary care centre: a retrospective study

Background: Caesarean section (C-section) is one of the most widely performed surgical procedure in obstetrics worldwide. The WHO guidelines revised in 1994 states that the proportion of C-section birth should range between 5-15% but both in developed and developing countries C-section rate is on the rise. This study was conducted to analyse the frequency and indications for C-section and associated maternal morbidity and mortality.Methods: This retrospective study was conducted over a period from January 2018 to May 2019 at the department of obstetrics and gynecology, NKP Salve Institute of Medical Sciences and Research Centre and Lata Mangeshkar Hospital, Hingna, Nagpur, Maharashtra, India. Data of patients who delivered by C-section in our hospital during the defined study period were studied and statistically analysed according to various parameters namely, the frequency of caesarean section, its indications, age, parity and gestational age of the patient.Results: The total number of women delivered over the study period were 2811. Out of which C-sections were done in 1461 women (51.97%). Previous C-section was the leading indication in 35.72% women followed by fetal distress 14.09%, failure of induction 12.93%, arrest of labour 7.93%, PIH 7.18%, oligo/IUGR 6.50%, breech 4.44%, refusal of vaginal birth 4.24%, CPD 1.71%, bad obstetrics history (BOH) 1.43%, malpresentation 1.30%, prematurity 1.23%,  and multifetal gestation in 1.09% women. Two women had classical C-section 0.07. 14.09% women had various complications. There was no maternal mortality.Conclusions: A high rate of caesarean deliveries was observed. Individualization of the indication and careful evaluation, following standardized guidelines can help us to limit C-section. Audit and feedback are the best way to judge clinical practice and to reduce the frequency of caesarean section in any tertiary setup.

Status Epilepticus following a Laparoscopic Surgery in a Patient of Chronic Kidney Disease – A Case Report

Seizures may occur in close relation to surgical procedures or with the use of anesthetic agents in several situations. Thecausative factors include an interruption of treatment with antiepileptic drugs (AEDs) or inadequate blood concentrations resultingfrom impaired gastrointestinal absorption. In operative procedures not involving the brain, transient seizures can arise frommetabolic derangements or drug neurotoxicity. Other causes include hypoxia, hypotension, and embolic infarction. Seizuresoccurring shortly after injection of moderate to large amounts of local anesthetic should raise the suspicion of inadvertentintravenous injection. Seizures may also indicate withdrawal from unsuspected chronic use of excessive amounts of alcohol,sedative medications, mood-stabilizing agents, or AEDs. Rarely, sleep deprivation and drugs like flumazenil may precipitateseizures. We discuss the management of status epilepticus following laparoscopic urology procedure in a patient of chronickidney disease with a history of the previous craniotomy.