RESUMO
Objective:To analyze the diagnosis and treatment of 1 case of primary bone marrow diffuse large B cell lymphoma (DLBCL),and to provide the reference for its dignosis and treatment. Methods:Combined the medical history and other auxiliary examination results, the possibility of diagnosis of primary bone marrow lymphoma (PBML)was suspected. Bone marrow biopsy and immunohistochemistry were carried out for diagnosis, and R-CHOP (rituximab, cyclophosphamide,doxorubicin,vincristine,and prednisolone) was selected as the chemotherapy scheme. Results:The diagnostic basis of the case was in accordance with the diagnostic standard of PBML.According to the results of immunohistochemical staining,it was classified as the DLBCL subtype. Then the patient received 6 cycles of R-CHOP immune chemotherapy. Complete remission of bone marrow cell morphology was gained after the first cycle of R-CHOP treatment,and the patient was treated for another five cycles and the complete remission was retained in 3 months of follow up after drug withdrawal. Conclusion:Bone marrow biospy and immunohistochemistry have the unique diagnostic values for primary bone marrow DLBCL,and the regimens containing rituximab may provide a ideal efficacy during short term observation.
RESUMO
Primary bone marrow lymphomas are infrequent. We report a case of primary bone marrow T-cell lymphoma in a 33-year old patient who has been treated as a hypocellular marrow. There was no enlarged lymph nodes or organomegaly. The peripheral blood smears showed several lymphoid atypical cells. The bone marrow biopsy revealed markedly increased cellularity and disclosed malignant lymphoma, diffuse, large-cell, immunoblastic type The lymphoma cells disclosed positive reaction in leukocyte common antigen (CD45) and UCHL-1 (CD45RO) antibodies which is compatible with a T-cell phenotype. The patient was received allogeneic bone marrow transplantation.