RESUMO
Based on the previous theory of supramolecular “imprinting template”, the historical evolution and research status together with the generation of four properties of Chinese materia medica (CMM) were analyzed and summarized by using supramolecular chemistry theory: Human and Chinese medicine are giant complex supramolecular systems with the same “imprinting template”. Different types (heat and cold) of active ingredients (guest molecules) of CMM and humans (host molecules) in different states bonded by non-covalent, releasing (or absorbing) energy, which can correct the self-recognition, self-organization, self-assembly, and self-replication of the body’s basic supramolecular attacked by cold or heat, in order to make the body back to normal, in short the macroscopic manifestation was four properties of CMM. Thus, two methods were proposed for four properties of CMM including in vivo and in vitro ones, the former one includes physical internal energy method and host-guest separation and supramolecular polymer preparation; In vivo method includes biological thermal studies, animal behavioral observations, and body surface temperature observations. The supramolecular “imprinting template” theory is a key for studying four properties of CMM, the combination between supramolecular chemistry theory and traditional Chinese medicine theory will certainly become a powerful method to promote the modernization of CMM.
RESUMO
Objective To find delayed luminescence parameters that could characterize the cold and hot properties of Arisaematis Rhizoma Preparatum and Arisaema Cum Bile. Methods Delayed luminescence of Arisaematis Rhizoma Preparatum with addition of Scenedesmus sp. within 26 d after decoction was measured in unequal interval, with aim to verify the stability of the natural delayed luminescence average strength and the linear fitting slope value (k) of excitation delayed luminescence. The delayed luminescence of six batches of Arisaematis Rhizoma Preparatum and Arisaema Cum Bile was measured using biological indicator method, and the content of β-sitosterol in Arisaematis Rhizoma Preparatum and β-sitosterol, bilirubin, and cholic acid of Arisaema Cum Bile was determined using high performance liquid chromatograph (HPLC) to analyze the correlation of k value and the above components content of Arisaematis Rhizoma Preparatum and Arisaema Cum Bile. Results K value of excitation delayed luminescence within 14 d after decoction was steadier than natural delayed luminescence average strength, and k values of six batches of Arisaematis Rhizoma Preparatum were all higher than that of Arisaema Cum Bile. A significant negative correlation between β-sitosterol contents and k values of six batches of Arisaematis Rhizoma Preparatum and Arisaema Cum Bile was found, and no significant negative correlation between bilirubin and cholic acid contents and k values of Arisaema Cum Bile was found. Conclusion K value of excitation delayed luminescence could indicate the differences of medicinal properties of Arisaematis Rhizoma Preparatum and Arisaema Cum Bile, which provides a new method for the study of medicinal properties of Chinese materia medica.