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Objective To analyze the clinical effects of sevoflurane and propofol anesthesia on hemorrheology in elderly patients with colorectal cancer undergoing radical mastectomy.Methods 86 patients with colorectal cancer undergoing radical surgery in our hospital from March 2014 to December 2016 were selected and randomly divided into sevoflurane group and propofol group group with 43 cases in each group.Two groups of elderly patients were anesthetized before, 40 minutes after induction, 80 minutes after induction, 140 minutes after induction and 30 minutes after entering the anesthesia monitoring room 30 minutes to draw the neck 4 mL venous blood.Analysised of two groups of patients with hemorheology ( low cut blood viscosity, blood viscosity in the cut, high shear whole blood viscosity, plasma viscosity, erythrocyte deformation index, erythrocyte aggregation index) index.Results There was no significant difference in the difference of detection indexes between sevoflurane group and propofol group at each time point Comparison of sevoflurane group and propofol group in elderly patients, 40 min, 80 min after induction and 140 min after induction compared with those of pre-anesthesia low-cut whole blood viscosity, middle whole blood viscosity, high shear whole blood viscosity and plasma viscosity, the difference was statistically significant(P<0.05), erythrocyte deformation index and erythrocyte agglutination index were not significantly different between the two groups.The blood viscosity in the propofol group was significantly lower than that in the anesthesia group at 80 minutes after induction and 140 minutes after induction, the difference between the two groups was statistically significant (P<0.05).The whole blood viscosity of the sevoflurane group was significantly lower than that before anesthesia at 140 min, and the difference between the two groups was statistically significant (P<0.05).Conclusion From the point of view of hemorheology, sevoflurane and propofol anesthesia can be used in elderly patients with colorectal cancer radical operation.
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BACKGROUND: A commercially available target-controlled propofol infusion system, the 'Diprifusor'TM is used for the induction and maintenance of anesthesia in adults, not in children because the pharmacokinetics of propofol in children. We wondered whether it is safe to use the 'Diprifusor'TM in children weighing over 30 kg in clinical practice? METHODS: Twenty unpremedicated children (8-15 yr, group 1) and sixty five unpremedicated adults (16-65 yr, group 2) scheduled for elective surgery were enrolled. After intravenous injection of fentanyl 1microgram/kg, a propofol infusion was started at a target concentration of 4microgram/ml using a 'Diprifusor'TM. We recorded the time to loss of eyelash reflex and effect site concentration at the time of loss of consciousness. Anesthesia was maintained with propofol-fentanyl-50% N2O-rocuronium. We also checked the effect site concentration at the time of eye opening to verbal command. RESULTS: The effect site concentrations at loss of eyelash reflex were 1.19 +/- 0.66microgram/ml (group 1) and 0.96 +/- 0.55microgram/ml (group 2), and these were not significantly different between the two groups. But the effect site concentrations at eye opening were 1.66 +/- 0.38microgram/ml (group 1) and 1.47 +/- 0.32microgram/ml (group 2) which were significantly different (P <0.05). CONCLUSIONS: 'Diprifusor'TM can be used safely in children weighing over 30 kg with a similar effect site concentration at loss of eyelash reflex as adults, but the effect site concentration at eye opening in children is slightly higher than that of adults.
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Adulto , Criança , Humanos , Anestesia , Fentanila , Injeções Intravenosas , Farmacocinética , Propofol , Reflexo , InconsciênciaRESUMO
0.05). Conclusion:The stress reaction to human injury stimulation are inhibited effectively by propofol - fentanyl intraveous anesthesia
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Objective To investigate the effect of propofol anesthesia on stress response and immune function of laproscopic cholecystectomy.Methods Corticosterone,glucose,complement concentrations in plasma of 20 ASAⅠ～Ⅱ patients under propofol combined anesthesia undergoing elective laproscopic cholecystectomy,were respectively determined before anesthesia,operation,gallbladder ablation and after de-intubation.Results After anesthesia,blood glucose increased while C3 and CH50 decreased gradually(P