Cyclooxygenase and gastrointestinal pathophysiology / 中国病理生理杂志

Cyclooxygenase is the key enzymes mediating prostaglandings release. In recent years, two isoforms of cyclooxygenase, a constitutive cyclooxygenase(COX-1)and an inducible cyclooxygenase (COX-2),have been identified, from which people have known more about gastrointestinal pathophysiology. This article is a review of COX-1 and COX-2 on the distribution, inducement and regulation in gastrointestinal tract and its relation to programmed cell death, tumor, ulcer and Crohn's disease.