Influences of Chuan Shen Tong Injection on Epidermal Growth Factor and Its Receptor in Human Benign Prostatic Hyperplasia / 中药新药与临床药理

Objective:To investigate the mechanism of Chuan Shen Tong Injection (CSTI) for benign prostatic hyperplasia (BPH).Methods:The distribution of epidermal growth factor (EGF) and epidermal growth factor receptor(EGFR) expression were detected with immunohistochemical technique in 49 samples of the excised prostate. Among them, 18 samples were from patients without intraglandular injection of CSTI (group A) as controls, 21 from those receiving injection but without effect (group B) and 10 from those receiving injection with effect but recur (group C).Results: The positive expression rates of interstitial EGF and EGFR in group B (81% and 71.4% respectively) increased as compared with group A (33.3% and 33.3% respectively.,P