Adulteration And Need Of Substitution Of Raw Materials – A Review

Experiencing challenges of modern medicine, globe is shifting towards the Ayurvedic theory of health management. In the treatment of disease use of medicine is practiced rampantly. This increased the demand of raw material exponentially. But, growth in production is still linear in nature. Fast depletion of resources is creating the major trouble. To meet the deficit, practices of adulteration and substitution are going on wildly. This adulteration and substitution became burning problem in industry threatening the integrity of Ayurveda. The deforestation, extinction or evolution of many species, insufficient knowledge, unauthenticated practices about identification, collection, storage and transport of raw material collectively resulted in adulteration. Strategic planning and integrated approach towards mass production, supply chain management, IEC, proper advocacy and knowledge sharing is needed to trim down the gravity of adulteration. “Prevention of Food Adulteration act 1954” describes technical definitions and guidelines for quality maintenance. Government is enforcing quality maintenance by implementation of “The Drug and Cosmetics Act 1940” For quality assurance, proper pharmacovigillance monitoring of raw materials and processes is very necessary. The concept of substitution is known in Ayurveda as it is enlightened prominently in Bhavprakash and Yogratnakar. However in scenario of crises, selection of substitute drugs may have upper edge over adulteration of the raw material. Scope of this article advocates that how adulteration and substitution are creating problems with respect to production of inferior quality medicines.

Quality Assuarance on Fine Needle Aspiration Cytology of Malignant Salivary Gland Neoplasms / 대한세포병리학회지

To evaluate the quality of fine needle aspiration cytology diagnosis on malignant salivary gland neoplasms, cytologic findings were correlated with histologic diagnosis of 56 surgically removed malignant salivary gland tumors. Seven cases (12.5%) were insufficient, 23 cases (41.1%) were diagnosed as malignant, 17 (30.4%) cases were accurately diagnosed by histologic subtype, and 9 cases (16%) were diagnosed as benign. Five out of 9 false negative cases were misdiagnosed as pleomorphic adenomas. Except the cases with insufficient specimen, overall sensitivity was 81.6%, and the sensitivity varied according to the histologic subtype; 91% in salivary duct carcinoma, 100% in carcinoma ex pleomorphic adenoma, 50% in mucoepidermoid carcinoma, 63% in adenoid cystic carcinoma, and 50% in acinic cell carcinoma. The diagnostic accuracy differed among cytopathologists irrespective of periods after acquisition of board of pathologists. These results confirm that salivary gland neoplasm can be easily misdiagnosed in fine needle aspiration cytology and a great caution should be given in diagnosing the benign appearing salivary aspirates to avoid under-diagnosis of malignant neoplasm with low grade cytologic atypia.